Shuyun Lin, Haijiao Long, Lianjie Hou, Ming Zhang, Jiang Ting, Haiyue Lin, Pan Zheng, Weixing Lei, Kai Yin, Guojun Zhao
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引用次数: 0
摘要
细胞暴露于心血管系统内的各种病理刺激,挑战细胞适应和生存。这些病理刺激改变了内质网(ER)的正常功能,导致未折叠和错误折叠蛋白的积累,从而触发未折叠蛋白反应(UPR)来应对应激或触发受损细胞的凋亡。UPR的下游组分调节转录和翻译重编程,以确保在病理刺激下选择性表达基因,包括非编码rna (ncRNAs)的表达。ncrna在调节转录和翻译中起着至关重要的作用,它们的异常表达与心血管疾病(CVD)的发生有关。值得注意的是,ncrna和内质网应激可以相互调节,协同影响CVD的发展。因此,研究内质网应激与ncrna的相互作用对于有效预防和治疗CVD是必要的。在这篇综述中,我们讨论了UPR信号通路和ncRNAs,以及内质网应激和ncRNAs在CVD中的相互作用调控,从而进一步了解CVD的发病机制和治疗策略。本文分类为:RNA in Disease and Development > RNA in Disease。
Crosstalk between endoplasmic reticulum stress and non-coding RNAs in cardiovascular diseases.
Cells are exposed to various pathological stimulus within the cardiovascular system that challenge cells to adapt and survive. Several of these pathological stimulus alter the normal function of the endoplasmic reticulum (ER), leading to the accumulation of unfolded and misfolded proteins, thus triggering the unfolded protein response (UPR) to cope with the stress or trigger apoptosis of damaged cells. Downstream components of the UPR regulate transcription and translation reprogramming to ensure selective gene expression in response to pathological stimulus, including the expression of non-coding RNAs (ncRNAs). The ncRNAs play crucial roles in regulating transcription and translation, and their aberrant expression is associated with the development of cardiovascular disease (CVD). Notably, ncRNAs and ER stress can modulate each other and synergistically affect the development of CVD. Therefore, studying the interaction between ER stress and ncRNAs is necessary for effective prevention and treatment of CVD. In this review, we discuss the UPR signaling pathway and ncRNAs followed by the interplay regulation of ER stress and ncRNAs in CVD, which provides further insights into the understanding of the pathogenesis of CVD and therapeutic strategies. This article is categorized under: RNA in Disease and Development > RNA in Disease.
期刊介绍:
WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.