皮肤屏障:具有特殊脂质组织的特殊界面。

IF 14 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Progress in lipid research Pub Date : 2023-09-04 DOI:10.1016/j.plipres.2023.101252
Joke A. Bouwstra , Andreea Nădăban , Wim Bras , Clare McCabe , Annette Bunge , Gerrit S. Gooris
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引用次数: 1

摘要

皮肤的屏障功能主要位于角质层(SC),即皮肤的最外层。SC由死细胞组成,细胞间隙中有高度组织化的脂质片层。由于脂质基质形成了唯一的连续途径,脂质在化合物通过SC的渗透中发挥着重要作用。主要的脂质类别是神经酰胺(CERs)、胆固醇(CHOL)和游离脂肪酸(FFAs)。SC脂质基质的分析对于理解皮肤屏障功能至关重要,不仅在健康皮肤中,而且在皮肤屏障受损的炎症性皮肤病中也是如此。在这篇综述中,我们提供了i)为获得健康皮肤和炎症性皮肤病SC中脂质组成和组织的信息而采取的步骤的历史概述,ii)关于CER的作用的信息,CHOL和FFA在非常复杂的脂质模型系统的脂质相行为中发挥作用,以及如何使用这些知识来理解炎症性皮肤病中脂质相行为的偏差,iii)关于两者的作用、CER亚类和链长分布、关于具有合成CER的复杂和简单模型系统中的脂质组织和脂质膜渗透性的知识,CHOL和FFAs,iv)不同物种和复杂模型系统的SC中脂相行为的相似性,以及vi)调节脂质组成的未来方向,有望改善炎症性皮肤病中的皮肤屏障。
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The skin barrier: An extraordinary interface with an exceptional lipid organization

The barrier function of the skin is primarily located in the stratum corneum (SC), the outermost layer of the skin. The SC is composed of dead cells with highly organized lipid lamellae in the intercellular space. As the lipid matrix forms the only continuous pathway, the lipids play an important role in the permeation of compounds through the SC. The main lipid classes are ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs). Analysis of the SC lipid matrix is of crucial importance in understanding the skin barrier function, not only in healthy skin, but also in inflammatory skin diseases with an impaired skin barrier. In this review we provide i) a historical overview of the steps undertaken to obtain information on the lipid composition and organization in SC of healthy skin and inflammatory skin diseases, ii) information on the role CERs, CHOL and FFAs play in the lipid phase behavior of very complex lipid model systems and how this knowledge can be used to understand the deviation in lipid phase behavior in inflammatory skin diseases, iii) knowledge on the role of both, CER subclasses and chain length distribution, on lipid organization and lipid membrane permeability in complex and simple model systems with synthetic CERs, CHOL and FFAs, iv) similarity in lipid phase behavior in SC of different species and complex model systems, and vi) future directions in modulating lipid composition that is expected to improve the skin barrier in inflammatory skin diseases.

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来源期刊
Progress in lipid research
Progress in lipid research 生物-生化与分子生物学
CiteScore
24.50
自引率
2.20%
发文量
37
审稿时长
14.6 weeks
期刊介绍: The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.
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