摄入褪黑素可预防最大运动后的肝损伤和改善肾功能的生物标志物。

IF 1.4 4区 教育学 Q3 HOSPITALITY, LEISURE, SPORT & TOURISM Research Quarterly for Exercise and Sport Pub Date : 2023-09-01 DOI:10.1080/02701367.2022.2068792
Mohamed Amine Farjallah, Ahmed Graja, Kais Ghattassi, Lobna Ben Mahmoud, Henda Elleuch, Fatma Ayadi, Tarak Driss, Kamel Jammoussi, Zouheir Sahnoun, Nizar Souissi, Omar Hammouda
{"title":"摄入褪黑素可预防最大运动后的肝损伤和改善肾功能的生物标志物。","authors":"Mohamed Amine Farjallah,&nbsp;Ahmed Graja,&nbsp;Kais Ghattassi,&nbsp;Lobna Ben Mahmoud,&nbsp;Henda Elleuch,&nbsp;Fatma Ayadi,&nbsp;Tarak Driss,&nbsp;Kamel Jammoussi,&nbsp;Zouheir Sahnoun,&nbsp;Nizar Souissi,&nbsp;Omar Hammouda","doi":"10.1080/02701367.2022.2068792","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> While the promotion of the beneficial effects of melatonin (MEL) ingestion on the modulation of oxidative stress is widespread, less attention is given to the biological influence that it could exert on the results of hematology and clinical chemistry parameters. This study was undertaken to assess the effects of acute MEL ingestion on these parameters during a maximal running exercise. <b>Methods:</b> In double blind randomized design, 12 professional soccer players [age: 17.54 ± 0.78 yrs, body mass: 70.31 ± 3.86 kg, body height: 1.8 ± 0.08 m; maximal aerobic speed (MAS): 16.85 ± 0.63 km/h; mean ± standard deviation], all males, performed a diurnal (17:00 h ± 30 h) running exercise test (RET) at 100% of their MAS following either MEL or placebo ingestion. Blood samples were obtained at rest and following the RET. <b>Results:</b> Compared to placebo, MEL intake decreased post-exercise biomarkers of liver damage (aspartate aminotransferase, p<0.001; alanine aminotransferase, p<0.001; gamma-glutamyltransferase; p<0.05) and improved post-exercise renal function markers (i.e., creatinine, p<0.001). However, lipid profile, glucose, lactate and leukocyte were not affected by MEL ingestion. Regarding the time to exhaustion, no difference was found between MEL (362.46 ± 42.06 s) and PLA (374.54 ± 57.97 s) conditions. <b>Conclusion:</b> The results of this investigation clearly attest that MEL ingestion before a maximal running exercise might protect athletes from liver damage and perturbation in renal function biomarkers. However, this study comprises an acute MEL supplementation and no assessment on chronic effects or circadian rhythm the day before was done.</p>","PeriodicalId":54491,"journal":{"name":"Research Quarterly for Exercise and Sport","volume":"94 3","pages":"869-879"},"PeriodicalIF":1.4000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Melatonin Ingestion Prevents Liver Damage and Improves Biomarkers of Renal Function Following a Maximal Exercise.\",\"authors\":\"Mohamed Amine Farjallah,&nbsp;Ahmed Graja,&nbsp;Kais Ghattassi,&nbsp;Lobna Ben Mahmoud,&nbsp;Henda Elleuch,&nbsp;Fatma Ayadi,&nbsp;Tarak Driss,&nbsp;Kamel Jammoussi,&nbsp;Zouheir Sahnoun,&nbsp;Nizar Souissi,&nbsp;Omar Hammouda\",\"doi\":\"10.1080/02701367.2022.2068792\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Background:</b> While the promotion of the beneficial effects of melatonin (MEL) ingestion on the modulation of oxidative stress is widespread, less attention is given to the biological influence that it could exert on the results of hematology and clinical chemistry parameters. This study was undertaken to assess the effects of acute MEL ingestion on these parameters during a maximal running exercise. <b>Methods:</b> In double blind randomized design, 12 professional soccer players [age: 17.54 ± 0.78 yrs, body mass: 70.31 ± 3.86 kg, body height: 1.8 ± 0.08 m; maximal aerobic speed (MAS): 16.85 ± 0.63 km/h; mean ± standard deviation], all males, performed a diurnal (17:00 h ± 30 h) running exercise test (RET) at 100% of their MAS following either MEL or placebo ingestion. Blood samples were obtained at rest and following the RET. <b>Results:</b> Compared to placebo, MEL intake decreased post-exercise biomarkers of liver damage (aspartate aminotransferase, p<0.001; alanine aminotransferase, p<0.001; gamma-glutamyltransferase; p<0.05) and improved post-exercise renal function markers (i.e., creatinine, p<0.001). However, lipid profile, glucose, lactate and leukocyte were not affected by MEL ingestion. Regarding the time to exhaustion, no difference was found between MEL (362.46 ± 42.06 s) and PLA (374.54 ± 57.97 s) conditions. <b>Conclusion:</b> The results of this investigation clearly attest that MEL ingestion before a maximal running exercise might protect athletes from liver damage and perturbation in renal function biomarkers. However, this study comprises an acute MEL supplementation and no assessment on chronic effects or circadian rhythm the day before was done.</p>\",\"PeriodicalId\":54491,\"journal\":{\"name\":\"Research Quarterly for Exercise and Sport\",\"volume\":\"94 3\",\"pages\":\"869-879\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Research Quarterly for Exercise and Sport\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/02701367.2022.2068792\",\"RegionNum\":4,\"RegionCategory\":\"教育学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"HOSPITALITY, LEISURE, SPORT & TOURISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research Quarterly for Exercise and Sport","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/02701367.2022.2068792","RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"HOSPITALITY, LEISURE, SPORT & TOURISM","Score":null,"Total":0}
引用次数: 2

摘要

背景:虽然褪黑激素(MEL)摄入对氧化应激调节的有益作用被广泛关注,但它对血液学和临床化学参数结果的生物学影响却很少被关注。本研究旨在评估在极限跑步运动中急性MEL摄入对这些参数的影响。方法:采用双盲随机设计,选取12名职业足球运动员[年龄:17.54±0.78岁,体重:70.31±3.86 kg,身高:1.8±0.08 m;最大有氧速度(MAS): 16.85±0.63 km/h;[平均±标准差],所有男性,在摄入MEL或安慰剂后,以100%的MAS进行每日(17:00 h±30 h)跑步运动试验(RET)。结果:与安慰剂相比,MEL的摄入降低了运动后肝损伤的生物标志物(天冬氨酸转氨酶,p)。结论:本研究的结果清楚地证明,在最大限度的跑步运动前摄入MEL可以保护运动员免受肝损伤和肾功能生物标志物的干扰。然而,本研究包括急性MEL补充,没有对前一天的慢性影响或昼夜节律进行评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Melatonin Ingestion Prevents Liver Damage and Improves Biomarkers of Renal Function Following a Maximal Exercise.

Background: While the promotion of the beneficial effects of melatonin (MEL) ingestion on the modulation of oxidative stress is widespread, less attention is given to the biological influence that it could exert on the results of hematology and clinical chemistry parameters. This study was undertaken to assess the effects of acute MEL ingestion on these parameters during a maximal running exercise. Methods: In double blind randomized design, 12 professional soccer players [age: 17.54 ± 0.78 yrs, body mass: 70.31 ± 3.86 kg, body height: 1.8 ± 0.08 m; maximal aerobic speed (MAS): 16.85 ± 0.63 km/h; mean ± standard deviation], all males, performed a diurnal (17:00 h ± 30 h) running exercise test (RET) at 100% of their MAS following either MEL or placebo ingestion. Blood samples were obtained at rest and following the RET. Results: Compared to placebo, MEL intake decreased post-exercise biomarkers of liver damage (aspartate aminotransferase, p<0.001; alanine aminotransferase, p<0.001; gamma-glutamyltransferase; p<0.05) and improved post-exercise renal function markers (i.e., creatinine, p<0.001). However, lipid profile, glucose, lactate and leukocyte were not affected by MEL ingestion. Regarding the time to exhaustion, no difference was found between MEL (362.46 ± 42.06 s) and PLA (374.54 ± 57.97 s) conditions. Conclusion: The results of this investigation clearly attest that MEL ingestion before a maximal running exercise might protect athletes from liver damage and perturbation in renal function biomarkers. However, this study comprises an acute MEL supplementation and no assessment on chronic effects or circadian rhythm the day before was done.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
4.30
自引率
0.00%
发文量
125
审稿时长
6-12 weeks
期刊介绍: Research Quarterly for Exercise and Sport publishes research in the art and science of human movement that contributes significantly to the knowledge base of the field as new information, reviews, substantiation or contradiction of previous findings, development of theory, or as application of new or improved techniques. The goals of RQES are to provide a scholarly outlet for knowledge that: (a) contributes to the study of human movement, particularly its cross-disciplinary and interdisciplinary nature; (b) impacts theory and practice regarding human movement; (c) stimulates research about human movement; and (d) provides theoretical reviews and tutorials related to the study of human movement. The editorial board, associate editors, and external reviewers assist the editor-in-chief. Qualified reviewers in the appropriate subdisciplines review manuscripts deemed suitable. Authors are usually advised of the decision on their papers within 75–90 days.
期刊最新文献
Genotypic Variations Associated with Changes in Body Mass in Response to Endurance Training. "Who's Got Talent?" Change of Direction, Anthropometric Characteristics and Maturity Offset Differences Between Elite and Sub-Elite Young Soccer Player. Types of Social Support Predicting Physical Activity and Quality of Life in Group Exercise Programs for Adults Living with Cancer. Social Network Negativity and Physical Activity: New Longitudinal Evidence for Young and Older Adults 2015-2018. Relationship Between Training Load, Neuromuscular Fatigue, and Daily Well-Being in Elite Young Wrestlers.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1