{"title":"基于同步加速器的x射线相位计算机断层扫描测量断裂二尖瓣腱索的结构特性。","authors":"Yojiro Koda, Takuro Tsukube, Masato Hoshino, Naoto Yagi, Hatsue Ishibashi-Ueda, Kenji Okada","doi":"10.1107/S1600577523005167","DOIUrl":null,"url":null,"abstract":"Tissue density measured by synchrotron-based X-ray phase computed tomography is shown to be associated with the fragility of the ruptured mitral chordae tendineae.","PeriodicalId":17114,"journal":{"name":"Journal of Synchrotron Radiation","volume":"30 Pt 5","pages":"995-1002"},"PeriodicalIF":2.4000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481270/pdf/","citationCount":"0","resultStr":"{\"title\":\"Structural properties in ruptured mitral chordae tendineae measured by synchrotron-based X-ray phase computed tomography.\",\"authors\":\"Yojiro Koda, Takuro Tsukube, Masato Hoshino, Naoto Yagi, Hatsue Ishibashi-Ueda, Kenji Okada\",\"doi\":\"10.1107/S1600577523005167\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Tissue density measured by synchrotron-based X-ray phase computed tomography is shown to be associated with the fragility of the ruptured mitral chordae tendineae.\",\"PeriodicalId\":17114,\"journal\":{\"name\":\"Journal of Synchrotron Radiation\",\"volume\":\"30 Pt 5\",\"pages\":\"995-1002\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481270/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Synchrotron Radiation\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://doi.org/10.1107/S1600577523005167\",\"RegionNum\":3,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INSTRUMENTS & INSTRUMENTATION\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Synchrotron Radiation","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1107/S1600577523005167","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INSTRUMENTS & INSTRUMENTATION","Score":null,"Total":0}
引用次数: 0
摘要
二尖瓣复合体的结构特性与腱索断裂之间的联系尚不清楚。基于同步辐射的x射线相位计算机断层扫描(SR-XPCT)成像是一种定量分析三维形态的创新方法。本研究采用XPCT对二尖瓣返流患者的腱索进行评价，并分析二尖瓣返流患者腱索断裂的结构变化。在二尖瓣反流手术修复中获得6例二尖瓣腱索断裂，并用福尔马林固定。此外，从尸检中获得了12条健康的腱索。采用XPCT(有效像素尺寸，3.5µm;密度分辨率为1 mg cm-3)，测量每个样品中腱索的密度。随后对标本进行病理分析。破裂组平均年龄为70.2±3.0岁，对照组平均年龄为67.2±14.1岁(p = 0.4927)。所有的SR-XPCT腱索扫描均成功完成。破裂组的平均密度为1.029±0.004，对照组的平均密度为1.085±0.015 g cm-3 (p < 0.0001)。基于SR-XPCT的二尖瓣腱索破裂的密度明显低于健康的腱索。组织学检查显示断裂腱索结缔组织成分发生变化，与SR-XPCT低密度测量一致。SR-XPCT使测量二尖瓣腱索组织密度成为可能。二尖瓣腱索的低密度与破裂的二尖瓣腱索的脆性有关。
Structural properties in ruptured mitral chordae tendineae measured by synchrotron-based X-ray phase computed tomography.
Tissue density measured by synchrotron-based X-ray phase computed tomography is shown to be associated with the fragility of the ruptured mitral chordae tendineae.
期刊介绍：
Synchrotron radiation research is rapidly expanding with many new sources of radiation being created globally. Synchrotron radiation plays a leading role in pure science and in emerging technologies. The Journal of Synchrotron Radiation provides comprehensive coverage of the entire field of synchrotron radiation and free-electron laser research including instrumentation, theory, computing and scientific applications in areas such as biology, nanoscience and materials science. Rapid publication ensures an up-to-date information resource for scientists and engineers in the field.
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