{"title":"伊朗不同类型牛奶中黄曲霉毒素M1的回顾、荟萃分析和致癌风险评估。","authors":"Fatemeh Mortezazadeh, Fathollah Gholami-Borujeni","doi":"10.1515/reveh-2022-0050","DOIUrl":null,"url":null,"abstract":"<p><strong>Reviews: </strong>Despite in recent decades, several studies on the concentration of aflatoxins M1(AFM1) in various milks have been studied, as we know, no systematic review, meta-analysis and carcinogenic risk assessment study was conducted in Iran till now.</p><p><strong>Objectives: </strong>In this study, a systematic review was conducted to collect, meta-analysis and carcinogenic risk assessment of the quantitative data regarding the prevalence and concentration of AFM1 in several types of milk produced in Iran.</p><p><strong>Content: </strong>In our study, the concentration and prevalence of AFM1 in different types of milk (Raw, pasteurized, and UHT) from 113 original articles in Iran using searching the Web of Science, PubMed, Scopus, Science Direct and Google Scholar (in Persian and English) databases from 2002 to august 2021 were collected. The concentration of AFM1 was meta-analyzed using the random effect model (REM) based on type of milk (raw, pasteurized and UHT) subgroups and Monte Carlo simulation (MCS) approach was used to assess safety risks and investigate carcinogenic effects of AFM1 using Crystal-Ball software (Version 11.1.3, Oracle, Inc., USA).</p><p><strong>Summary and outlook: </strong>The 113 original article (In English and Persian) were included in this review. Meta-analysis indicated lower and upper of AFM1 in subgroups of raw, pasteurized and UHT milk in Iran was 9, 720, 2.7, 230.2, 19.23, and 221.6 ng/kg respectively. The Point estimate for carcinogenic risk of AFM1 showed as result of age increasing, the carcinogenic risk of Aflatoxin M 1 decreases and concentration of Aflatoxin M1 (ng/liter), plays the most effective role in carcinogenic risk of AFM1.</p><p><strong>Conclusion: </strong>The presence of AFM1 in milk and its products due to its high toxicity and carcinogenic properties is a public health concern that the results show that the risk of carcinogenesis is higher at younger ages (less than 20 years). As a result, there is a strong association between consumption of raw milk, pasteurized milk and UHT and the risk of cancer in children and adults in Iran.</p>","PeriodicalId":21165,"journal":{"name":"Reviews on Environmental Health","volume":"38 3","pages":"511-518"},"PeriodicalIF":3.0000,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Review, meta-analysis and carcinogenic risk assessment of aflatoxin M1 in different types of milks in Iran.\",\"authors\":\"Fatemeh Mortezazadeh, Fathollah Gholami-Borujeni\",\"doi\":\"10.1515/reveh-2022-0050\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Reviews: </strong>Despite in recent decades, several studies on the concentration of aflatoxins M1(AFM1) in various milks have been studied, as we know, no systematic review, meta-analysis and carcinogenic risk assessment study was conducted in Iran till now.</p><p><strong>Objectives: </strong>In this study, a systematic review was conducted to collect, meta-analysis and carcinogenic risk assessment of the quantitative data regarding the prevalence and concentration of AFM1 in several types of milk produced in Iran.</p><p><strong>Content: </strong>In our study, the concentration and prevalence of AFM1 in different types of milk (Raw, pasteurized, and UHT) from 113 original articles in Iran using searching the Web of Science, PubMed, Scopus, Science Direct and Google Scholar (in Persian and English) databases from 2002 to august 2021 were collected. The concentration of AFM1 was meta-analyzed using the random effect model (REM) based on type of milk (raw, pasteurized and UHT) subgroups and Monte Carlo simulation (MCS) approach was used to assess safety risks and investigate carcinogenic effects of AFM1 using Crystal-Ball software (Version 11.1.3, Oracle, Inc., USA).</p><p><strong>Summary and outlook: </strong>The 113 original article (In English and Persian) were included in this review. Meta-analysis indicated lower and upper of AFM1 in subgroups of raw, pasteurized and UHT milk in Iran was 9, 720, 2.7, 230.2, 19.23, and 221.6 ng/kg respectively. The Point estimate for carcinogenic risk of AFM1 showed as result of age increasing, the carcinogenic risk of Aflatoxin M 1 decreases and concentration of Aflatoxin M1 (ng/liter), plays the most effective role in carcinogenic risk of AFM1.</p><p><strong>Conclusion: </strong>The presence of AFM1 in milk and its products due to its high toxicity and carcinogenic properties is a public health concern that the results show that the risk of carcinogenesis is higher at younger ages (less than 20 years). 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引用次数: 1
摘要
综述：尽管近几十年来，对各种牛奶中黄曲霉毒素M1（AFM1）的浓度进行了几项研究，但我们知道，迄今为止，伊朗还没有进行系统综述、荟萃分析和致癌风险评估研究。目的：本研究对伊朗生产的几种牛奶中AFM1的流行率和浓度的定量数据进行了系统的收集、荟萃分析和致癌风险评估。内容：在我们的研究中，2002年至2021年8月，使用搜索Web of Science、PubMed、Scopus、Science Direct和Google Scholar（波斯语和英语）数据库，收集了伊朗113篇原创文章中不同类型牛奶（生牛奶、巴氏灭菌牛奶和超高温灭菌牛奶）中AFM1的浓度和流行率。使用随机效应模型（REM）对AFM1的浓度进行元分析，该模型基于牛奶类型（生的、巴氏灭菌的和UHT）亚组，并使用蒙特卡罗模拟（MCS）方法评估安全风险，并使用Crystal-Ball软件（11.1.3版，Oracle，股份有限公司，USA）研究AFM1的致癌作用包含在本综述中。荟萃分析表明，伊朗生牛奶、巴氏灭菌牛奶和超高温灭菌牛奶亚组中AFM1的下限和上限分别为9200、2.7230.2、19.23和221.6纳克/公斤。AFM1致癌风险的点估计表明：随着年龄的增长，黄曲霉毒素M1的致癌风险降低，结论：牛奶及其制品中存在的AFM1由于其高毒性和致癌特性而引起公众健康关注，研究结果表明，年轻人（20岁以下）致癌风险更高。因此，在伊朗，生牛奶、巴氏灭菌牛奶和超高温灭菌与儿童和成人癌症风险之间存在着强烈的关联。
Review, meta-analysis and carcinogenic risk assessment of aflatoxin M1 in different types of milks in Iran.
Reviews: Despite in recent decades, several studies on the concentration of aflatoxins M1(AFM1) in various milks have been studied, as we know, no systematic review, meta-analysis and carcinogenic risk assessment study was conducted in Iran till now.
Objectives: In this study, a systematic review was conducted to collect, meta-analysis and carcinogenic risk assessment of the quantitative data regarding the prevalence and concentration of AFM1 in several types of milk produced in Iran.
Content: In our study, the concentration and prevalence of AFM1 in different types of milk (Raw, pasteurized, and UHT) from 113 original articles in Iran using searching the Web of Science, PubMed, Scopus, Science Direct and Google Scholar (in Persian and English) databases from 2002 to august 2021 were collected. The concentration of AFM1 was meta-analyzed using the random effect model (REM) based on type of milk (raw, pasteurized and UHT) subgroups and Monte Carlo simulation (MCS) approach was used to assess safety risks and investigate carcinogenic effects of AFM1 using Crystal-Ball software (Version 11.1.3, Oracle, Inc., USA).
Summary and outlook: The 113 original article (In English and Persian) were included in this review. Meta-analysis indicated lower and upper of AFM1 in subgroups of raw, pasteurized and UHT milk in Iran was 9, 720, 2.7, 230.2, 19.23, and 221.6 ng/kg respectively. The Point estimate for carcinogenic risk of AFM1 showed as result of age increasing, the carcinogenic risk of Aflatoxin M 1 decreases and concentration of Aflatoxin M1 (ng/liter), plays the most effective role in carcinogenic risk of AFM1.
Conclusion: The presence of AFM1 in milk and its products due to its high toxicity and carcinogenic properties is a public health concern that the results show that the risk of carcinogenesis is higher at younger ages (less than 20 years). As a result, there is a strong association between consumption of raw milk, pasteurized milk and UHT and the risk of cancer in children and adults in Iran.
期刊介绍：
Reviews on Environmental Health (REVEH) is an international peer-reviewed journal that aims to fill the need for publication of review articles on hot topics in the field of environmental health. Reviews on Environmental Health aims to be an inspiring forum for scientists, environmentalists, physicians, engineers, and students who are concerned with aspects of human health, including quality of life, that are determined by physiological and psychosociological interactions between man and physical, chemical, biological, and social factors in the environment.
Reviews on Environmental Health is an important niche served by no other journal, that’s being a site where thoughtful reviews can be published on a variety of subjects related to both health and environment. One challenge is to bridge the research on environmental causes of disease with the clinical practice of medicine. Reviews on Environmental Health is a source of integrated information on environment and health subjects that will be of value to the broad scientific community, whether students, junior and senior professionals, or clinicians.
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