LC-MS/MS和GC-MS/MS不同贮存条件下多残留农药混合物稳定性研究及处理建议

IF 1.7 4区 农林科学 Q3 CHEMISTRY, ANALYTICAL Journal of AOAC International Pub Date : 2023-11-02 DOI:10.1093/jaoacint/qsad096
Landon A Wiest, Jana R Hepner, Jason E Fisher, Karen M Risha, John H Lidgett, Valerie N Ballarotto, Joseph D Konschnik
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引用次数: 0

摘要

背景:为了应对全球对农药残留检测日益增长的需求,实验室必须开发多功能的分析方法和工作流程,以产生科学合理的结果。食品化学家面临的众多挑战之一是获得合适的农药认证参考物质(CRM),以校准分析设备,监测方法性能,并确认食品样品中数百种农药残留的身份和浓度。CRM生产商投入大量资源以确保其产品的稳定性。目的:根据几项多残留农药稳定性研究的结果,提出适当的CRM处理和储存实践,以确保稳定性。方法:在控制条件下进行开放安瓿和多残留混合研究。在冷冻和冷藏温度下储存时,打开含有多种残留农药CRM混合物的新安瓿,并与之前打开的安瓿进行多次比较。将LC和GC适用的农药(>200个残留物)合并并在典型的实验室条件下储存。研究是在有和没有芹菜基质的情况下进行的。结果:开放式安瓿研究显示,所有混合物的稳定性都很高。所有GC残留物在实验期间保持稳定。开启LC后一周,多种残留农药混合物出现轻微降解。组合多种残留农药混合物后,GC和LC混合物都发生了快速降解。结论:多残留农药混合物在打开前是稳定的。一旦试剂盒的内容物被打开并组合,随着时间的推移,观察到稳定性下降。LC和GC试剂盒都是如此。应每天制作用于仪器校准的CRM的工作混合物。亮点:本文展示了一种测量CRM混合物稳定性的新方法。对多种残留农药混合物进行了深入分析,并描述了在典型储存条件下混合前后的稳定性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Stability Study and Handling Recommendations for Multiresidue Pesticide Mixes under Diverse Storage Conditions for LC-MS/MS and GC-MS/MS.

Background: In response to the growing global need for pesticide residue testing, laboratories must develop versatile analytical methods and workflows to produce scientifically sound results. One of the many challenges faced by food chemists is acquiring suitable pesticide certified reference materials (CRMs) to calibrate analytical equipment, monitor method performance, and confirm the identity and concentration of hundreds of pesticide residues in food samples. CRM producers invest considerable resources to ensure the stability of their products.

Objective: To present proper CRM handling and storage practices as guidance to ensure stability based on the results of several multiresidue pesticide stability studies.

Methods: The open ampoule and combined multiresidue mix studies were conducted under controlled conditions. New ampoules containing multiresidue pesticide CRM mixtures were opened and compared to previously opened ampoules at multiple intervals while stored under freezing and refrigerated temperatures. Both LC- and GC-amenable pesticides (>200 residues) were combined and stored under typical laboratory conditions. Studies were performed with and without celery matrix.

Results: The open ampoule study showed high levels of stability for all mixtures. All GC residues remained stable over the duration of the experiment. A week after opening LC multiresidue pesticide mixtures showed minor degradation. After combination of the multiresidue pesticide mixtures, degradation occurred rapidly for both the GC and LC mixtures.

Conclusion: Multiresidue pesticide mixtures are stable as ampullated until they are opened. Once the contents of a kit were opened and combined, decreasing stability was observed over time. This was true for both the LC and GC kits. Working mixtures of CRMs for instrument calibration should be made daily.

Highlights: This article shows a novel approach for measuring stability of CRM mixes. In-depth analysis of multiresidue pesticide mixtures and the stability that can be expected before and after mixing under typical storage conditions is described.

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来源期刊
Journal of AOAC International
Journal of AOAC International 医学-分析化学
CiteScore
3.10
自引率
12.50%
发文量
144
审稿时长
2.7 months
期刊介绍: The Journal of AOAC INTERNATIONAL publishes the latest in basic and applied research in analytical sciences related to foods, drugs, agriculture, the environment, and more. The Journal is the method researchers'' forum for exchanging information and keeping informed of new technology and techniques pertinent to regulatory agencies and regulated industries.
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