性缺乏和发情期对强迫性行为的影响,采用计划诱导的大鼠烦渴程序进行评估。

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES Behavioural Pharmacology Pub Date : 2023-06-01 DOI:10.1097/FBP.0000000000000723
Min Park-Oates, Adam J Prus
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引用次数: 0

摘要

用于筛选精神障碍药物治疗的临床前行为模型通常只使用男性研究对象,而对于包括女性受试者的研究,很少使用性别作为研究变量。事实上,许多精神障碍在患病率和症状上因性别而异,因此有必要评估已建立的性别差异主题模型。强迫行为是许多精神障碍共有的特征,在大鼠身上使用时间表诱导的多饮程序进行了临床前的有效治疗。减少烦渴的有效药物包括精神兴奋剂,如d -安非他明。实际上,还没有研究使用这种方法来检验性别差异。在本研究中,雄性和雌性大鼠在计划性多饮范式下进行了检查。大鼠的食物受到限制,并按照固定间隔的食物强化计划进行训练,并在实验期间免费获得水。在训练和测试期间评估发情阶段。精神兴奋剂d -安非他明也在稳定饮水后进行了测试。在训练过程中摄入过多的水。女性需要更多的时间来达到稳定的饮酒水平。d -安非他明(1.0 mg/kg,而不是0.25或0.5 mg/kg)显著减少了雄性和雌性大鼠的饮水量。在其他研究变量中,包括发情期和发情前期的比较,没有观察到性别差异。总的来说,这些发现表明,采用类似方法的计划性多饮程序可以在男性和女性受试者中产生普遍的结果。
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Lack of sex and estrous stage effects on compulsive behavior assessed using a schedule-induced polydipsia procedure in rats.

Preclinical behavior models used for screening pharmacological treatments for mental disorders have generally used only male research subjects, and for studies that have included female subjects, few have utilized sex as a study variable. In fact, many mental disorders vary by prevalence and symptomatology between sexes, creating a need to evaluate established subject models for sex differences. Compulsive behavior is a feature shared across many mental disorders and effective treatments have been examined pre-clinically using the schedule-induced polydipsia procedure in rats. Drugs effective for reducing polydipsia include psychostimulants, such as d -amphetamine. Virtually no studies have examined sex differences using this procedure. For the present study, male and female rats were examined in the schedule-induced polydipsia paradigm. Rats were food-restricted and trained on a fixed-interval food reinforcement schedule and given free access to water during experimental sessions. Estrous stages were assessed during training and test sessions. The psychostimulant d -amphetamine was also tested once stable water consumption occurred. Excessive water intake developed over the course of training. Females required significantly more sessions to reach a stable level of drinking. Treatment with d -amphetamine (1.0 mg/kg, but not 0.25 or 0.5 mg/kg) significantly reduced drinking in both male and female rats. No sex differences were observed across other study variables including comparisons between diestrus and proestrus stages. Overall, these findings suggest that schedule-induced polydipsia procedures that employ similar methods can produce results generalizable across male and female subjects.

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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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