The 21st century engram.

The search for the engram-the neural mechanism of memory-has been a guiding research project for neuroscience since its emergence as a distinct scientific field. Recent developments in the tools and techniques available for investigating the mechanisms of memory have allowed researchers to proclaimed the search is over. While there is ongoing debate about the justification for that claim, renewed interest in the engram is clear. This attention highlights the impoverished status of the engram concept. As research accelerates, the simple characterization of the engram as an enduring physical change is stretched thin. Now that the engram commitment has been made more explicit, it must also be made more precise. If the project of 20th century neurobiology was finding the engram, the project of the 21st must be supplying a richer account of what's been found. This paper sketches a history of the engram, and a way forward. This article is categorized under: Philosophy > Foundations of Cognitive Science.