多房棘球蚴原头节段通过PI3K/Akt/mTOR信号通路增强糖酵解促进M2巨噬细胞。

IF 4.9 4区医学 Q1 PARASITOLOGY Pathogens and Global Health Pub Date : 2023-06-01 DOI:10.1080/20477724.2022.2104055

Tao Zhang, Yaogang Zhang, Zihan Yang, Yuan Jiang, Li Sun, Dengliang Huang, Meiyuan Tian, Yinhong Shen, Jun Deng, Jing Hou, Yanyan Ma

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引用次数: 2

摘要

肺泡棘球蚴病(AE)是一种由多房棘球蚴引起的人畜共患寄生虫病，其发病机制尚不清楚。本研究的主要目的是探讨多房棘球蚴原头节棘球蚴(PSCs)是否通过PI3K/Akt/mTOR信号通路调节巨噬细胞极化和葡萄糖代谢。我们发现AE患者病变处有大量CD68+巨噬细胞聚集在近距离肝组织中。PSCs优先分化为M2巨噬细胞，HK1、PFKL、PKM2、PI3K、Akt、p-Akt、mTOR、p-mTOR表达升高。以上结果表明，多房棘球蚴原头节段通过PI3K/Akt/mTOR信号通路增强糖酵解，促进M2巨噬细胞的生长。

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Echinococcus multilocularis protoscoleces enhance glycolysis to promote M2 Macrophages through PI3K/Akt/mTOR Signaling Pathway.

Alveolar Echinococcosis (AE) is a zoonotic parasitic disease caused by Echinococcus multilocularis, but its pathogenesis remains unclear. The primary objective of this study is to explore whether Echinococcus multilocularis protoscoleces (PSCs) regulate macrophage polarization and glucose metabolism by PI3K/Akt/mTOR signaling pathway. We found that large numbers of CD68⁺ macrophages gathered in close liver issue from the lesion in AE patients. PSCs preferentially differentiated into M2 macrophages and the expressions of HK1, PFKL, PKM2, PI3K, Akt, p-Akt, mTOR and p-mTOR increased. The above results show that Echinococcus multilocularis protoscoleces enhance glycolysis to promote M2 macrophages through PI3K/Akt/mTOR signaling pathway.

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来源期刊

Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY

CiteScore

6.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.