Saulo Ribeiro Silveira, Beatriz Danieletto Sahm, Simone Kreve, Andréa Cândido dos Reis
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引用次数: 2
摘要
石墨烯的使用具有优异的机械性能。然而，有必要评估这种材料的生物效应。本系统综述旨在通过研究观察和了解应用于牙科植入材料表面的石墨烯涂层在骨整合、抗菌能力和细胞毒性方面的最新技术。PubMed、Embase、Science Direct、Web of Science和Google Scholar数据库的搜索于2021年6月至7月进行，并于2022年5月更新，关键词为：石墨烯、氧化石墨烯、牙科植入物、锆、钛、peek、铝、二硅酸盐、甲基丙烯酸甲酯、细胞毒性、骨整合和骨再生。标准包括体内和体外研究，这些研究评估了涂有石墨烯化合物的牙科植入材料的抗菌能力和/或骨整合和/或细胞毒性。体外研究的偏倚风险通过JBI工具进行评估，而体内研究则使用Syrcle的动物研究偏倚风险工具。数据库搜索得到176篇文章。在被选为全文阅读的18篇文章中，有16篇仍在本系统综述中。石墨烯化合物作为植入材料表面的涂层是有前景的，因为它可以促进骨整合并具有抗菌能力。然而，还需要进一步的研究来确保其细胞毒性潜力。
Osseointegration, antimicrobial capacity and cytotoxicity of implant materials coated with graphene compounds: A systematic review
The use of graphecs excellent mechanical properties. However, it is necessary to evaluate the biological effects of this material. This systematic review aimed to observe and understand through studies the current state of the art regarding osseointegration, antimicrobial capacity, and the cytotoxicity of graphene coating applied to the surface of dental implant materials.
Searches in PubMed, Embase, Science Direct, Web of Science, and Google Scholar databases were conducted between June and July 2021 and updated in May 2022 using the keywords: graphene, graphene oxide, dental implants, zirconium, titanium, peek, aluminum, disilicate, methyl-methacrylate, cytotoxicity, osseointegration, and bone regeneration. The criteria included in vivo and in vitro studies that evaluated antimicrobial capacity and/or osseointegration and/or cytotoxicity of dental implant materials coated with graphene compounds. The risk of bias for in vitro studies was assessed by the JBI tool, and for in vivo studies, Syrcle's risk of bias tool for animal studies was used.
The database search resulted in 176 articles. Of the 18 articles selected for full reading, 16 remained in this systematic review.
The use of graphene compounds as coatings on the surface of implant materials is promising because it promotes osseointegration and has antimicrobial capacity. However, further studies are needed to ensure its cytotoxic potential.
期刊介绍：
The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.
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