肺立体定向放射治疗靶体积内定义不确定度的探讨。

IF 1.7 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Radiological Physics and Technology Pub Date : 2023-12-01 Epub Date: 2023-09-15 DOI:10.1007/s12194-023-00737-y
Daiki Nakanishi, Masataka Oita, Jun-Ichi Fukunaga, Taka-Aki Hirose, Tadamasa Yoshitake, Motoharu Sasaki
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引用次数: 0

摘要

本研究评估了三维(3DCT)和四维计算机断层扫描(4DCT)定义的内部靶体积(ITVs)的有效性,并随后将其与治疗期间的实际运动进行了比较。对5例肺上叶肿瘤患者进行48 Gy立体定向放射治疗(SBRT)。在屏气高峰和屏气高峰下获取规划的3DCT图像,在自由呼吸下获取电影模式下的4DCT图像。在照射过程中使用电子门静脉成像装置获得电影图像。肿瘤覆盖的评估是基于计划CT上的峰值呼吸幅值在左右、前后和颅尾(CC)方向上覆盖肿瘤运动范围(±3 SD)的方式。在CC方向上,4dct为基础的ITV的平均肿瘤覆盖率优于3dct为基础的ITV。在设置4DCT照射场时,应考虑内缘。本文提出的基于4dct的ITV覆盖范围优于3DCT,可作为肺上叶肿瘤自由呼吸SBRT的有效方法。
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Investigation of uncertainty in internal target volume definition for lung stereotactic body radiotherapy.

This study evaluated the validity of internal target volumes (ITVs) defined by three- (3DCT) and four-dimensional computed tomography (4DCT), and subsequently compared them with actual movements during treatment. Five patients with upper lobe lung tumors were treated with stereotactic body radiotherapy (SBRT) at 48 Gy in four fractions. Planning 3DCT images were acquired with peak-exhale and peak-inhale breath-holds, and 4DCT images were acquired in the cine mode under free breathing. Cine images were acquired using an electronic portal imaging device during irradiation. Tumor coverage was evaluated based on the manner in which the peak-to-peak breathing amplitude on the planning CT covered the range of tumor motion (± 3 SD) during irradiation in the left-right, anteroposterior, and cranio-caudal (CC) directions. The mean tumor coverage of the 4DCT-based ITV was better than that of the 3DCT-based ITV in the CC direction. The internal margin should be considered when setting the irradiation field for 4DCT. The proposed 4DCT-based ITV can be used as an efficient approach in free-breathing SBRT for upper-lobe tumors of the lung because its coverage is superior to that of 3DCT.

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来源期刊
Radiological Physics and Technology
Radiological Physics and Technology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
3.00
自引率
12.50%
发文量
40
期刊介绍: The purpose of the journal Radiological Physics and Technology is to provide a forum for sharing new knowledge related to research and development in radiological science and technology, including medical physics and radiological technology in diagnostic radiology, nuclear medicine, and radiation therapy among many other radiological disciplines, as well as to contribute to progress and improvement in medical practice and patient health care.
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