传统和数字工作流程之间的诊断一致性。1427例前列腺活检的研究。

IF 4.4 Q1 PATHOLOGY PATHOLOGICA Pub Date : 2023-08-01 DOI:10.32074/1591-951X-896
Evelin Torresani, Maria Adalgisa Gentilini, Stefano Grassi, Luca Cima, Irene Pedrolli, Tommaso Cai, Marco Puglisi, Valentino Vattovani, Bianca Guadin, Matteo Brunelli, Claudio Doglioni, Mattia Barbareschi
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引用次数: 0

摘要

目的:评价传统载玻片(TS)与全载玻片(WSI)在观察者内诊断的可重复性。方法:对连续107例1427例前列腺活检患者的TS和WSI进行单一病理学评估。使用Gwet的一致系数(AC)和Landis和Koch基准量表评估读数之间的一致性。结果:两组读数正/负一致性几乎完美(AC1= 0.962;95% CI[0.949,0.974]),差异分布与方法无关。阳性活检患者TS、WSI Gleason评分一致的212例,不一致的69例(AC2 = 0.932;95% ci[0.907, 0.956])。阴性和阳性患者分型一致的分别为39例和64例;TS阳性组2例,WSI阳性组2例,基本一致(AC1=0.929;95% c1[0.860, 0.998])。在60例一致阳性病例中评估ISUP分级组(ISUP GG)一致性,其中45例TS和WSI相同;在10个活检中,差异意味着指定的ISUP GG的修改≤1级,在5个差异意味着修改2级。Gwet的一致系数为(95% CI[0.834, 0.962]),即:几乎完全一致。结论:我们的数据显示,在常规设置中,数字化和传统诊断活动几乎完全一致,证实了数字化病理学可以安全地引入常规工作流程。
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Diagnostic concordance between traditional and digital workflows. A study on 1427 prostate biopsies.

Objective: To evaluate intra-observer diagnostic reproducibility using traditional slides (TS) versus whole slide images (WSI).

Methods: TS and WSI of 1427 prostatic biopsies (107 consecutive patients) were evaluated by a single pathologist. Agreement between readings was evaluated with Gwet's Agreement coefficient (AC) and Landis and Koch benchmark scale.

Results: The positive/negative agreement between the readings was almost perfect (AC1= 0.962; 95% CI[0.949,0.974]), with method independent distribution of discrepancies. Among positive biopsies, 212 had identical Gleason score (GS) on TS and WSI and discordant GS in 69 cases (AC2 = 0.932; 95% CI[0.907, 0.956]). Concordant negative and positive patient classification was observed in 39 and 64 cases, respectively; two cases were assigned to the positive group on TS and 2 on WSI configuring an almost perfect agreement (AC1=0.929; 95% C1[0.860, 0.998]). ISUP Grade group (ISUP GG) agreement was evaluated in the 60 concordantly positive cases: in 45 cases it was identical on TS and WSI; in 10 biopsies the discrepancy implied a modification of the assigned ISUP GG of ≤ 1 class and in 5 the discrepancy implied a modification of 2 classes. Gwet's agreement coefficient was (95% CI [0.834, 0.962]), i.e.: almost perfect agreement.

Conclusions: Our data show almost perfect agreement between digital and traditional diagnostic activity in a routine setting, confirming that digital pathology can be safely introduced into routine workflows.

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来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
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