非核糖体肽合成酶重编程的最新进展。

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Peptide Science Pub Date : 2023-09-18 DOI:10.1002/psc.3545

Fumihiro Ishikawa, Shinya Nakamura, Isao Nakanishi, Genzoh Tanabe

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引用次数: 0

摘要

非核糖体肽合成酶（NRPSs）可生物合成非核糖体肽（NRP）天然产物，这些天然产物具有广泛的治疗用途，是最有希望用于药物发现和开发的资源。遗传学、生物化学和生物信息学分析的结果加深了我们对 NRPS 机制的了解。NRP 生物合成的一个主要目标是对 NRPS 机制进行重新编程，以实现设计肽的生物合成生产。近年来，NRPS 机器的重编程策略取得了长足的进步，从而提高了产量并产生了改性肽。本文介绍了 NRPS 重编程的最新进展及其在多肽合成中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent progress in the reprogramming of nonribosomal peptide synthetases

Nonribosomal peptide synthetases (NRPSs) biosynthesize nonribosomal peptide (NRP) natural products, which belong to the most promising resources for drug discovery and development because of their wide range of therapeutic applications. The results of genetic, biochemical, and bioinformatics analyses have enhanced our understanding of the mechanisms of the NRPS machinery. A major goal in NRP biosynthesis is to reprogram the NRPS machinery to enable the biosynthetic production of designed peptides. Reprogramming strategies for the NRPS machinery have progressed considerably in recent years, thereby increasing the yields and generating modified peptides. Here, the recent progress in NRPS reprogramming and its application in peptide synthesis are described.

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来源期刊

Journal of Peptide Science 生物-分析化学

CiteScore

3.40

自引率

4.80%

发文量

审稿时长

1.7 months

期刊介绍： The official Journal of the European Peptide Society EPS The Journal of Peptide Science is a cooperative venture of John Wiley & Sons, Ltd and the European Peptide Society, undertaken for the advancement of international peptide science by the publication of original research results and reviews. The Journal of Peptide Science publishes three types of articles: Research Articles, Rapid Communications and Reviews. The scope of the Journal embraces the whole range of peptide chemistry and biology: the isolation, characterisation, synthesis properties (chemical, physical, conformational, pharmacological, endocrine and immunological) and applications of natural peptides; studies of their analogues, including peptidomimetics; peptide antibiotics and other peptide-derived complex natural products; peptide and peptide-related drug design and development; peptide materials and nanomaterials science; combinatorial peptide research; the chemical synthesis of proteins; and methodological advances in all these areas. The spectrum of interests is well illustrated by the published proceedings of the regular international Symposia of the European, American, Japanese, Australian, Chinese and Indian Peptide Societies.