孟加拉国糖尿病患者的药物依从性和健康相关生活质量:一项横断面研究

IF 2.7 Q3 ENDOCRINOLOGY & METABOLISM Endocrinology, Diabetes and Metabolism Pub Date : 2023-07-25 DOI:10.1002/edm2.444
Sabrina Ahmed, K. M. Saif-Ur-Rahman, Raja Ram Dhungana, Gantsetseg Ganbaatar, Fatema Ashraf, Yuichiro Yano, Katsuyuki Miura, M. S. A. Mansur Ahmed
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引用次数: 0

摘要

良好的抗糖尿病药物依从性是减少糖尿病相关并发症和残疾的重要保护因素,但其与健康相关生活质量(HRQoL)的关系尚未得到充分研究。目前的研究旨在评估孟加拉国达卡市糖尿病患者抗糖尿病药物依从性与HRQoL之间的关系。方法我们对在达卡市一家三级医院就诊的480例50 - 70岁糖尿病患者进行了横断面研究。采用EuroQol-5维度问卷(EQ-5D-5L)测量HRQoL, Morisky药物依从性量表评估抗糖尿病药物依从性水平。采用多变量logistic回归评估相关因素的显著性。结果参与者的平均年龄为59.0岁(标准差[SD], 7.0)。大多数参与者(74%)的药物依从性较低。EQ-5D-5L的平均值为2.0 (SD, 1.0)。不同领域的严重残疾比例分别为6.7%的行动能力、3.5%的自我照顾、11.9%的日常活动、11.9%的疼痛/不适和11.3%的焦虑。在调整了年龄、性别、受教育年限、家庭支出、高血压、糖尿病病程、血糖状况和多种疾病后;抗糖尿病药物依从性低与疼痛呈负相关(OR, 0.26;95% ci, 0.08-0.80;p = 0.036),且与焦虑呈正相关(OR, 7.18;95% ci, 1.03-9.59;p = .043)。结论:孟加拉国达卡市糖尿病患者EQ-5D-5L指数显示,抗糖尿病药物依从性低与焦虑和疼痛有关。
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Medication adherence and health-related quality of life among people with diabetes in Bangladesh: A cross-sectional study

Introduction

Good adherence to anti-diabetic medications is an important protective factor for decreasing diabetes-related complications and disabilities but its association with health-related quality of life (HRQoL) is understudied. The current study aimed to assess an association between medication adherence to anti-diabetic drugs and HRQoL among people with diabetes in Dhaka city, Bangladesh.

Methods

We conducted a cross-sectional study among 480 people with diabetes aged between 50 and 70 years, who attended a tertiary-level hospital in Dhaka city. We used the EuroQol-5 Dimensions Questionnaire (EQ-5D-5L) to measure HRQoL and Morisky Medication Adherence Scale to assess the level of medication adherence to anti-diabetic drugs. Multivariable logistic regression was performed to assess the significance of relevant factors.

Results

The mean age of the participants was 59.0 (standard deviation [SD], 7.0) years. The majority of the participants (74%) had a lower level of medication adherence. The mean value of (EQ-5D-5L) was 2.0 (SD, 1.0). The percentage of severe disability in different domains were 6.7% for mobility, 3.5% for self-care, 11.9% for usual daily activities, 11.9% for pain/discomfort and 11.3% for anxiety. After adjusting for age, sex, years of education, household expenditure, hypertension, duration of diabetes, glycemic status and multi-morbidities; low adherence to anti-diabetic medication was inversely associated with pain (OR, 0.26; 95% CI, 0.08–0.80; p = .036), and positively associated with anxiety (OR, 7.18; 95% CI, 1.03–9.59; p = .043).

Conclusions

Low medication adherence to anti-diabetic drugs was associated with anxiety and pain among the EQ-5D-5L indexes measured in people with diabetes in Dhaka, Bangladesh.

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来源期刊
Endocrinology, Diabetes and Metabolism
Endocrinology, Diabetes and Metabolism Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
5.00
自引率
0.00%
发文量
66
审稿时长
6 weeks
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