射血分数保留型心力衰竭的炎症机制

IF 5.3 2区 医学 Q1 PHYSIOLOGY Physiology Pub Date : 2023-09-01 Epub Date: 2023-04-04 DOI:10.1152/physiol.00004.2023
Daniel Daou, Thomas G Gillette, Joseph A Hill
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引用次数: 0

摘要

射血分数保留型心力衰竭(HFpEF)是目前最常见的心力衰竭形式,也是一个重要的公共卫生问题,目前有效的治疗方法有限。合并症负担引发的炎症是 HFpEF 病理生理学的关键因素。在此,我们将讨论合并症驱动的全身和心肌炎症的证据,以及炎症在 HFpEF 病理心肌重塑中的机制作用。
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Inflammatory Mechanisms in Heart Failure with Preserved Ejection Fraction.

Heart failure with preserved ejection fraction (HFpEF) is now the most common form of heart failure and a significant public health concern for which limited effective therapies exist. Inflammation triggered by comorbidity burden is a critical element of HFpEF pathophysiology. Here, we discuss evidence for comorbidity-driven systemic and myocardial inflammation and the mechanistic role of inflammation in pathological myocardial remodeling in HFpEF.

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来源期刊
Physiology
Physiology 医学-生理学
CiteScore
14.50
自引率
0.00%
发文量
37
期刊介绍: Physiology journal features meticulously crafted review articles penned by esteemed leaders in their respective fields. These articles undergo rigorous peer review and showcase the forefront of cutting-edge advances across various domains of physiology. Our Editorial Board, comprised of distinguished leaders in the broad spectrum of physiology, convenes annually to deliberate and recommend pioneering topics for review articles, as well as select the most suitable scientists to author these articles. Join us in exploring the forefront of physiological research and innovation.
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