Sarah Gondek, Mateusz Ogledzinski, William Lin, Kamila Milejczyk, Braden Juengel, Lisa Potter, Piotr J Bachul, Lindsay Basto, Laurencia Perea, Ling-Jia Wang, Martin Tibudan, Zuzanna Witkowska, Rolf Barth, John Fung, Piotr Witkowski
{"title":"胰岛移植和随后的两次妊娠后长期胰岛素独立的持续。","authors":"Sarah Gondek, Mateusz Ogledzinski, William Lin, Kamila Milejczyk, Braden Juengel, Lisa Potter, Piotr J Bachul, Lindsay Basto, Laurencia Perea, Ling-Jia Wang, Martin Tibudan, Zuzanna Witkowska, Rolf Barth, John Fung, Piotr Witkowski","doi":"10.31373/ejtcm/166178","DOIUrl":null,"url":null,"abstract":"<p><p>Pregnancy increases metabolic demand for insulin and may lead to the exhaustion of intraportally transplanted islets and post-gestational hyperglycemia. To prevent these complications, we implemented preemptive insulin supplementation during two subsequent pregnancies in an insulin-independent islet transplant recipient. This strategy resulted in optimal blood glucose control during the pregnancies, the preservation of the optimal islet graft function and the postpartum maintenance of long-term insulin independence.</p>","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485871/pdf/nihms-1911385.pdf","citationCount":"0","resultStr":"{\"title\":\"Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies.\",\"authors\":\"Sarah Gondek, Mateusz Ogledzinski, William Lin, Kamila Milejczyk, Braden Juengel, Lisa Potter, Piotr J Bachul, Lindsay Basto, Laurencia Perea, Ling-Jia Wang, Martin Tibudan, Zuzanna Witkowska, Rolf Barth, John Fung, Piotr Witkowski\",\"doi\":\"10.31373/ejtcm/166178\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Pregnancy increases metabolic demand for insulin and may lead to the exhaustion of intraportally transplanted islets and post-gestational hyperglycemia. To prevent these complications, we implemented preemptive insulin supplementation during two subsequent pregnancies in an insulin-independent islet transplant recipient. This strategy resulted in optimal blood glucose control during the pregnancies, the preservation of the optimal islet graft function and the postpartum maintenance of long-term insulin independence.</p>\",\"PeriodicalId\":52409,\"journal\":{\"name\":\"European Journal of Translational and Clinical Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485871/pdf/nihms-1911385.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Translational and Clinical Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31373/ejtcm/166178\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Translational and Clinical Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31373/ejtcm/166178","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies.
Pregnancy increases metabolic demand for insulin and may lead to the exhaustion of intraportally transplanted islets and post-gestational hyperglycemia. To prevent these complications, we implemented preemptive insulin supplementation during two subsequent pregnancies in an insulin-independent islet transplant recipient. This strategy resulted in optimal blood glucose control during the pregnancies, the preservation of the optimal islet graft function and the postpartum maintenance of long-term insulin independence.