J. Zawadzki, Jacek Gajek, Agnieszka Sławuta, Dariusz Kozłowski, Gabriel Zaborniak, B. Kudliński
Background : Bachmann’s bundle plays a crucial role in the physiology of interatrial signal conduction. In the 1970s, Bayes de Luna introduced the definition of interatrial blocks (IABs), which negatively influence atrioven - tricular (AV) synchrony and left atrial (LA) activation. We aimed to assess the potential of LA strain technology in evaluating the mechanics of LA in patients with correct conduction and IABs. Additionally, we measured the pa - rameters of regurgitation in pulmonary veins (PV), which depend on the type of interatrial conduction. Material and methods: The study group comprised 51 patients (26 male, 25 female) with symptomatic COVID-19 and si - nus rhythm. Our study analyzed their medical history, electrocardiography (ECG) and echocardiography, including the LA strain parameters. Results: Global peak atrial longitudinal strain (PALS) depended on P-wave duration, LA volume, left ventricular ejection fraction (LVEF) and inferior pulmonary veins (PV) regurgitation parameters. Glo - bal peak atrial contractile strain (PACS) statistically depends on the LVEF, LA volume and the P-wave morphology. Conclusions: The presence of IABs negatively influences PACS and PALS. Examining LA strain is complementary to accurate ECG, which may be helpful in everyday clinical practice, particularly in diagnosing heart failure with preserved ejection fraction (HFpEF) and as a predictor of new episodes of atrial fibrillation (AF).
背景：巴赫曼束在心房间信号传导的生理学中起着至关重要的作用。20 世纪 70 年代，Bayes de Luna 提出了心房间阻滞（IAB）的定义，它对房室（AV）同步和左心房（LA）激活有负面影响。我们的目的是评估 LA 应变技术在评估正确传导和 IAB 患者 LA 力学方面的潜力。此外，我们还测量了肺静脉（PV）反流的直径，这取决于房室间传导的类型。材料和方法：研究组包括 51 名有症状的 COVID-19 和心律不齐的患者（26 名男性，25 名女性）。我们的研究分析了他们的病史、心电图和超声心动图，包括 LA 应变参数。研究结果全球心房纵向应变峰值（PALS）取决于P波持续时间、LA容积、左室射血分数（LVEF）和下肺静脉（PV）反流参数。全球心房收缩应变峰值（PACS）在统计学上取决于 LVEF、LA 容积和 P 波形态。结论：IAB 的存在对 PACS 和 PALS 有负面影响。检查 LA 应变是对精确心电图的补充，在日常临床实践中可能会有所帮助，尤其是在诊断射血分数保留型心力衰竭（HFpEF）和预测心房颤动（AF）的新发作方面。
{"title":"An echocardiographic tool for the interatrial conduction disorders – old dog, new tricks?","authors":"J. Zawadzki, Jacek Gajek, Agnieszka Sławuta, Dariusz Kozłowski, Gabriel Zaborniak, B. Kudliński","doi":"10.31373/ejtcm/177894","DOIUrl":"https://doi.org/10.31373/ejtcm/177894","url":null,"abstract":"Background : Bachmann’s bundle plays a crucial role in the physiology of interatrial signal conduction. In the 1970s, Bayes de Luna introduced the definition of interatrial blocks (IABs), which negatively influence atrioven - tricular (AV) synchrony and left atrial (LA) activation. We aimed to assess the potential of LA strain technology in evaluating the mechanics of LA in patients with correct conduction and IABs. Additionally, we measured the pa - rameters of regurgitation in pulmonary veins (PV), which depend on the type of interatrial conduction. Material and methods: The study group comprised 51 patients (26 male, 25 female) with symptomatic COVID-19 and si - nus rhythm. Our study analyzed their medical history, electrocardiography (ECG) and echocardiography, including the LA strain parameters. Results: Global peak atrial longitudinal strain (PALS) depended on P-wave duration, LA volume, left ventricular ejection fraction (LVEF) and inferior pulmonary veins (PV) regurgitation parameters. Glo - bal peak atrial contractile strain (PACS) statistically depends on the LVEF, LA volume and the P-wave morphology. Conclusions: The presence of IABs negatively influences PACS and PALS. Examining LA strain is complementary to accurate ECG, which may be helpful in everyday clinical practice, particularly in diagnosing heart failure with preserved ejection fraction (HFpEF) and as a predictor of new episodes of atrial fibrillation (AF).","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139447449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bartosz Skonieczny, Agnieszka Sławuta, J. Radziejewska, Dariusz Jagielski, Jacek Gajek, Dariusz Kozłowski
Background : Heart failure (HF) constitutes a complex clinical entity and often coexists with atrial fibrillation (AF). There is a scarcity of evidence-based therapies for those with ejection fraction (EF) ≥ 40%. The effect restoring regular ventricular response in patients with HF with EF ≥ 40% and concomitant permanent AF is unknown. Me-thods: This was a retrospective case-series study. 14 patients with symptomatic HF with EF ≥ 40% and permanent AF who had undergone permanent His bundle pacing (pHBP) were identified and enrolled. For 9 patients pHBP was a primary strategy, for the remaining patients it was an upgrade from right single chamber ventricular pacing. All patients underwent a follow-up visit 3 months after the procedure. Results: The severity of HF based on the New York Heart Association (NYHA) class was significantly reduced post-pHBP (mean 2.5 vs. 1.0, p-value < 0.001). Left ventricular ejection fraction significantly increased (mean increase 8.5%, p < 0.001) Similarly, significant de - crease in the left ventricular end-diastolic diameter was observed after pHBP (mean decrease 5.4 mm, p < 0.001). The degree of mitral regurgitation after three months was lower (mean grade 2.4 vs. 1.2, p < 0.001). Conclusions: Permanent HBP might be beneficial in the setting of permanent AF and HF with EF ≥ 40%.
{"title":"His bundle pacing in patients with permanent atrial fibrillation and heart failure with non-reduced ejection fraction – retrospective study","authors":"Bartosz Skonieczny, Agnieszka Sławuta, J. Radziejewska, Dariusz Jagielski, Jacek Gajek, Dariusz Kozłowski","doi":"10.31373/ejtcm/177892","DOIUrl":"https://doi.org/10.31373/ejtcm/177892","url":null,"abstract":"Background : Heart failure (HF) constitutes a complex clinical entity and often coexists with atrial fibrillation (AF). There is a scarcity of evidence-based therapies for those with ejection fraction (EF) ≥ 40%. The effect restoring regular ventricular response in patients with HF with EF ≥ 40% and concomitant permanent AF is unknown. Me-thods: This was a retrospective case-series study. 14 patients with symptomatic HF with EF ≥ 40% and permanent AF who had undergone permanent His bundle pacing (pHBP) were identified and enrolled. For 9 patients pHBP was a primary strategy, for the remaining patients it was an upgrade from right single chamber ventricular pacing. All patients underwent a follow-up visit 3 months after the procedure. Results: The severity of HF based on the New York Heart Association (NYHA) class was significantly reduced post-pHBP (mean 2.5 vs. 1.0, p-value < 0.001). Left ventricular ejection fraction significantly increased (mean increase 8.5%, p < 0.001) Similarly, significant de - crease in the left ventricular end-diastolic diameter was observed after pHBP (mean decrease 5.4 mm, p < 0.001). The degree of mitral regurgitation after three months was lower (mean grade 2.4 vs. 1.2, p < 0.001). Conclusions: Permanent HBP might be beneficial in the setting of permanent AF and HF with EF ≥ 40%.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139446755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-14DOI: 10.24018/clinicmed.2023.4.6.256
Inês Rodrigues de Oliveira, Joana Filipa Ganhão Palma
The hand and the forearm are the main defensive organs and more than often they suffer serious traumatism in car accidents. Guiding these patients to rehabilitation areas is essential for the success of the process. The present case refers to a multiple trauma patient who suffered a car accident which had great impact on his upper left limb. The patient was treated at Hospital de São José, and later transferred for the Centro de Medicina e Reabilitação do Sul to start his rehabilitation. The complete description of the process in Occupational Therapy/Hand Therapy starts here, with the intention of evaluating the impact of this type of intervention on a multiple trauma patient, by assessing the evolution of the open wound, scar, edema, sensitiveness, joint range, muscular activation, limb functionality as well as Instrumental and Daily Life Activities. Despite improvements at motor and sensory levels, these were not as expected, as a result of the severity of the injuries and the late rehabilitation beginning. Nonetheless, at the functionality level the patient was able to achieve improvement levels that allowed a greater independence and a return to his job. A timely reference for treatment, in this case of multiple trauma in the upper limb, could have allowed for a greater success in the rehabilitation, at the same time, a more effective communication among all the structures involved in the case since the moment of the accident until rehabilitation would also have led to a faster closing of the wound, which would have a positive influence in the results. Although, and even with the late start, the Hand Therapy intervention was paramount for the patient’s independence.
手和前臂是主要的防御器官，在交通事故中往往遭受严重的创伤。引导这些病人到康复区对康复过程的成功至关重要。本病例是指一个多重创伤的病人，他遭受了一次车祸，对他的左上肢体有很大的影响。病人在shospital de s o jossore接受治疗，后来转到s o do Sul医疗中心开始康复。《职业治疗/手部治疗》中对这一过程的完整描述从这里开始，目的是通过评估开放性伤口、疤痕、水肿、敏感性、关节范围、肌肉激活、肢体功能以及工具和日常生活活动的演变，评估这类干预对多重创伤患者的影响。尽管运动和感觉水平有所改善，但由于损伤的严重程度和康复开始较晚，这些并没有如预期的那样。尽管如此，在功能水平上，患者能够达到改善水平，允许更大的独立性和重返工作。在上肢多发创伤的病例中，及时参考治疗可以使康复取得更大的成功，同时，从事故发生的那一刻起，在该病例所涉及的所有结构之间进行更有效的沟通，直到康复，也会导致更快地闭合伤口，这将对结果产生积极的影响。虽然，即使开始晚了，手部治疗干预对病人的独立性至关重要。
{"title":"Reeducation of the Upper Limb: A Case Study of a Multiple Trauma Patient, Who Suffered a Car Accident","authors":"Inês Rodrigues de Oliveira, Joana Filipa Ganhão Palma","doi":"10.24018/clinicmed.2023.4.6.256","DOIUrl":"https://doi.org/10.24018/clinicmed.2023.4.6.256","url":null,"abstract":"The hand and the forearm are the main defensive organs and more than often they suffer serious traumatism in car accidents. Guiding these patients to rehabilitation areas is essential for the success of the process. The present case refers to a multiple trauma patient who suffered a car accident which had great impact on his upper left limb. The patient was treated at Hospital de São José, and later transferred for the Centro de Medicina e Reabilitação do Sul to start his rehabilitation. The complete description of the process in Occupational Therapy/Hand Therapy starts here, with the intention of evaluating the impact of this type of intervention on a multiple trauma patient, by assessing the evolution of the open wound, scar, edema, sensitiveness, joint range, muscular activation, limb functionality as well as Instrumental and Daily Life Activities. Despite improvements at motor and sensory levels, these were not as expected, as a result of the severity of the injuries and the late rehabilitation beginning. Nonetheless, at the functionality level the patient was able to achieve improvement levels that allowed a greater independence and a return to his job. A timely reference for treatment, in this case of multiple trauma in the upper limb, could have allowed for a greater success in the rehabilitation, at the same time, a more effective communication among all the structures involved in the case since the moment of the accident until rehabilitation would also have led to a faster closing of the wound, which would have a positive influence in the results. Although, and even with the late start, the Hand Therapy intervention was paramount for the patient’s independence.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134957157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.24018/clinicmed.2023.4.6.317
Evita Gašenko, Andrejs Pčolkins, Inga Bogdanova, Signe Plāte
Background: Colorectal cancer (CRC) patients with peritoneal metastasis have the worst prognosis with a median overall survival of 4.1–8.5 months [1],[2]. Aim: To assess results in the elderly metastatic CRC patient with peritoneal dissemination treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) with oxaliplatin. Case Presented: Patient - 70-year-old female with metastatic CRC and peritoneal carcinomatosis. Prior to surgery, received 12 of chemotherapy FOLFOX + bevacizumab. CRS + HIPEC was performed followed by an uneventful recovery. After surgery, she has received chemotherapy with FOLFIRI. The disease progressed 14 months later. The patient has continued therapy with FOLFIRI, unfortunately, the disease has progressed and oral therapy with ftorafur has commenced. Patients’ overall survival so far is 48 months. Conclusions: Even though we cannot decisively distinguish if results are determined by CRS or additional HIPEC, the presented case shows the importance of a paradigm shift when peritoneal disease in selected patients is viewed as a regional disease rather than diffuse metastatic.
{"title":"Cytoreductive Surgery and HIPEC in Elderly Patient with Colorectal Cancer and Peritoneal Metastasis","authors":"Evita Gašenko, Andrejs Pčolkins, Inga Bogdanova, Signe Plāte","doi":"10.24018/clinicmed.2023.4.6.317","DOIUrl":"https://doi.org/10.24018/clinicmed.2023.4.6.317","url":null,"abstract":"Background: Colorectal cancer (CRC) patients with peritoneal metastasis have the worst prognosis with a median overall survival of 4.1–8.5 months [1],[2]. Aim: To assess results in the elderly metastatic CRC patient with peritoneal dissemination treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) with oxaliplatin. Case Presented: Patient - 70-year-old female with metastatic CRC and peritoneal carcinomatosis. Prior to surgery, received 12 of chemotherapy FOLFOX + bevacizumab. CRS + HIPEC was performed followed by an uneventful recovery. After surgery, she has received chemotherapy with FOLFIRI. The disease progressed 14 months later. The patient has continued therapy with FOLFIRI, unfortunately, the disease has progressed and oral therapy with ftorafur has commenced. Patients’ overall survival so far is 48 months. Conclusions: Even though we cannot decisively distinguish if results are determined by CRS or additional HIPEC, the presented case shows the importance of a paradigm shift when peritoneal disease in selected patients is viewed as a regional disease rather than diffuse metastatic.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135393239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-17DOI: 10.24018/clinicmed.2023.4.5.312
Stanislaw R. Burzynski, Gregory S. Burzynski, Tomasz J. Janicki, Samuel W. Beenken
Optic pathway glioma (OPG) is a low-grade tumor developing along the pre-cortical optic pathways and can involve the optic nerve, optic chiasm, optic tracts, and hypothalamus. Objective: A male child with newly diagnosed and unresectable OPG is presented to 1) review the earliest use of Antineoplastons A10 and AS2-1 for the treatment of brain tumors and 2) demonstrate the efficacy of Antineoplastons in the treatment of OPG. On April 18, 1988, a seven-year-old male child presented to the Burzynski Clinic (BC) with headaches. Based on prior, non-enhanced MRIs and biopsy, an unresectable suprasellar OPG was diagnosed. Antineoplaston therapy was started on a “proof of principle” basis. Tumor response was measured by magnetic resonance imaging (MRI) scans of the brain. Results: A brain MRI, performed on May 31, 1989, demonstrated an enhancing suprasellar nodule measuring 4.37 cm2. On August 24, 1990, brain MRI demonstrated a 0.96 cm2 enhancing nodule, indicating the achievement of a partial response (PR). Following higher dose intravenous (IV) and oral Antineoplastons, brain MRI performed on January 24, 1997, demonstrated a residual 0.4 cm2 enhancing nodule, indicating an enduring PR. All Antineoplaston therapy was discontinued on August 21, 2000. At last follow-up, > 35 years since the start of Antineoplaston therapy, the patient was healthy and showed no evidence of tumor progression. “Proof of principle” Antineoplaston therapy utilized in a seven-year-old male with unresectable OPG produced an objective response (OR) and prolonged overall survival. Antineoplaston therapy is an attractive therapeutic option for children with OPG.
{"title":"Inoperable Optic Pathway Glioma: A Seven-Year-Old Male with >35 Years Overall Survival Following Treatment with Antineoplastons","authors":"Stanislaw R. Burzynski, Gregory S. Burzynski, Tomasz J. Janicki, Samuel W. Beenken","doi":"10.24018/clinicmed.2023.4.5.312","DOIUrl":"https://doi.org/10.24018/clinicmed.2023.4.5.312","url":null,"abstract":"Optic pathway glioma (OPG) is a low-grade tumor developing along the pre-cortical optic pathways and can involve the optic nerve, optic chiasm, optic tracts, and hypothalamus. Objective: A male child with newly diagnosed and unresectable OPG is presented to 1) review the earliest use of Antineoplastons A10 and AS2-1 for the treatment of brain tumors and 2) demonstrate the efficacy of Antineoplastons in the treatment of OPG. On April 18, 1988, a seven-year-old male child presented to the Burzynski Clinic (BC) with headaches. Based on prior, non-enhanced MRIs and biopsy, an unresectable suprasellar OPG was diagnosed. Antineoplaston therapy was started on a “proof of principle” basis. Tumor response was measured by magnetic resonance imaging (MRI) scans of the brain. Results: A brain MRI, performed on May 31, 1989, demonstrated an enhancing suprasellar nodule measuring 4.37 cm2. On August 24, 1990, brain MRI demonstrated a 0.96 cm2 enhancing nodule, indicating the achievement of a partial response (PR). Following higher dose intravenous (IV) and oral Antineoplastons, brain MRI performed on January 24, 1997, demonstrated a residual 0.4 cm2 enhancing nodule, indicating an enduring PR. All Antineoplaston therapy was discontinued on August 21, 2000. At last follow-up, > 35 years since the start of Antineoplaston therapy, the patient was healthy and showed no evidence of tumor progression. “Proof of principle” Antineoplaston therapy utilized in a seven-year-old male with unresectable OPG produced an objective response (OR) and prolonged overall survival. Antineoplaston therapy is an attractive therapeutic option for children with OPG.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135993920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The incidence of concurrent hypoprolactinemia and impaired bone mineral density (IBMD) induced by marijuana abuse has not been observed among the general population. To the very best of our knowledge, none of these two rare conditions have previously been documented among Nigerians, within the existing literature. Case Report: Herein, is a rare case of concurrent hypoprolactinemia and IBMD triggered by marijuana abuse, in a 21-year-old undergraduate Nigerian male, who is a regular/heavy marijuana smoker of thirteen months duration. He had presented in our medical facility with complaints of recurrent excruciating lower back pain of three weeks duration which intensified with walking and while undertaking weight-bearing activities. He attested to having and seeking medical attention for, excessive sweating, and insomnia symptoms before the onset of current presenting symptoms. Results of investigations showed positive urine test for marijuana, hypoprolactinemia, distortions of biomarkers of bone metabolism, and radiologic features consistent with IBMD, Having found no other discernible cause of the low back/hip pain and hyoprolactinemia, he was diagnosed clinically with hypoprolactinemia and IBMD secondary to marijuana abuse. This warranted hospital admission where he obtained standardized specialist medical care and was subsequently discharged in good clinical condition with an uneventful follow-up period. Conclusion: This case highlights the dangers of metabolic aberrations due to marijuana abuse and the need to always maintain a high index of suspicion when confronted with it to avoid unnecessary medical protocols.
{"title":"Marijuana-Provoked Hypoprolactinemia and Impaired Bone Mineral Density: Case Report and Review of Literature","authors":"Collins Amadi, Friday Enwumelu Aaron, Bright Chike Amadi, Chidozie Johnbosco Okafor, Ezra Agbo","doi":"10.24018/clinicmed.2023.4.5.309","DOIUrl":"https://doi.org/10.24018/clinicmed.2023.4.5.309","url":null,"abstract":"Introduction: The incidence of concurrent hypoprolactinemia and impaired bone mineral density (IBMD) induced by marijuana abuse has not been observed among the general population. To the very best of our knowledge, none of these two rare conditions have previously been documented among Nigerians, within the existing literature. Case Report: Herein, is a rare case of concurrent hypoprolactinemia and IBMD triggered by marijuana abuse, in a 21-year-old undergraduate Nigerian male, who is a regular/heavy marijuana smoker of thirteen months duration. He had presented in our medical facility with complaints of recurrent excruciating lower back pain of three weeks duration which intensified with walking and while undertaking weight-bearing activities. He attested to having and seeking medical attention for, excessive sweating, and insomnia symptoms before the onset of current presenting symptoms. Results of investigations showed positive urine test for marijuana, hypoprolactinemia, distortions of biomarkers of bone metabolism, and radiologic features consistent with IBMD, Having found no other discernible cause of the low back/hip pain and hyoprolactinemia, he was diagnosed clinically with hypoprolactinemia and IBMD secondary to marijuana abuse. This warranted hospital admission where he obtained standardized specialist medical care and was subsequently discharged in good clinical condition with an uneventful follow-up period. Conclusion: This case highlights the dangers of metabolic aberrations due to marijuana abuse and the need to always maintain a high index of suspicion when confronted with it to avoid unnecessary medical protocols.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136142954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-16DOI: 10.24018/clinicmed.2023.4.5.311
Augustine O. Takure, Bankole A. Adewumi
Background: There is misconception about male Infertility and erectile dysfunction (ED) with poor health seeking behaviour in our clime. This study aims at finding the association between erectile dysfunction and male infertility in Ibadan. Methods: This was a retrospective comparative study that analysed records of all men with male infertility between May 2016 and April 2023 at the surgical outpatient in a tertiary hospital in Ibadan. Data included demography, social habit, the severity and prevalence of ED, and type of infertility. The data were analysed with a Statistical Package for the Social Sciences (SPSS) version 25. Logistic regression analysed the association between male infertility and erectile dysfunction. A p-value of < 0.05 was regarded as statistically significant. Results: A total of 109 cases of male infertility of which 65 (59.6%) had ED. The overall mean age for primary and secondary infertility were 37.62 ± 6.95years and 40.62 ± 8.322 years respectively (t=2.892; p< 0.004). The mean age for absence and presence of ED were 39.08 ± 6.61years and 39.56 ± 7.94years respectively (t=0.340; p= 0.734). There is association between alcohol consumption and ED (χ2=6.969; p< 0.008). Similarly, statistically significant association between the ED and the type of infertility as mild, mild-moderate, and moderate ED were commoner among men with primary infertility and all men with severe ED had secondary infertility (χ2=12.283; p<0.015). Conclusions: The prevalence of erectile dysfunction among male infertility was 59.6% with statistically significant association between the severity of ED and male infertility. Public awareness is advocated.
{"title":"Erectile Dysfunction among Male Infertile Men Attending the Surgical Outpatient Clinic in a Tertiary Hospital in Nigeria over a 7-Year Period—A Single Surgeon’s Experience","authors":"Augustine O. Takure, Bankole A. Adewumi","doi":"10.24018/clinicmed.2023.4.5.311","DOIUrl":"https://doi.org/10.24018/clinicmed.2023.4.5.311","url":null,"abstract":"Background: There is misconception about male Infertility and erectile dysfunction (ED) with poor health seeking behaviour in our clime. This study aims at finding the association between erectile dysfunction and male infertility in Ibadan. Methods: This was a retrospective comparative study that analysed records of all men with male infertility between May 2016 and April 2023 at the surgical outpatient in a tertiary hospital in Ibadan. Data included demography, social habit, the severity and prevalence of ED, and type of infertility. The data were analysed with a Statistical Package for the Social Sciences (SPSS) version 25. Logistic regression analysed the association between male infertility and erectile dysfunction. A p-value of < 0.05 was regarded as statistically significant. Results: A total of 109 cases of male infertility of which 65 (59.6%) had ED. The overall mean age for primary and secondary infertility were 37.62 ± 6.95years and 40.62 ± 8.322 years respectively (t=2.892; p< 0.004). The mean age for absence and presence of ED were 39.08 ± 6.61years and 39.56 ± 7.94years respectively (t=0.340; p= 0.734). There is association between alcohol consumption and ED (χ2=6.969; p< 0.008). Similarly, statistically significant association between the ED and the type of infertility as mild, mild-moderate, and moderate ED were commoner among men with primary infertility and all men with severe ED had secondary infertility (χ2=12.283; p<0.015). Conclusions: The prevalence of erectile dysfunction among male infertility was 59.6% with statistically significant association between the severity of ED and male infertility. Public awareness is advocated.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136178317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-29DOI: 10.24018/clinicmed.2023.4.5.293
Anastasios Tzenalis, Maria Giouldouri, George Kipourgos, George Elesnitsalis
Background: Job satisfaction of nurses is an issue that has focused intense attention in recent years, mainly due to the widespread reduction, worldwide, in the number of nursing personnel. Purpose to investigate the influence of the work environment of the intensive care unit on nurses and to identify the factors that play a decisive role in job satisfaction. Materials and Methods: Our study involved 100 intensive care unit nurses who completed a questionnaire focusing on nurses’ job satisfaction. Tests used are T-test, Mann-Whitney U (test of two independent samples), Anova, KruskalWallis to test distributions. The non-parametric tests analyzed with two independent variables T-test, Anova, Pearson, one-sample t-Test respectively. Results: Employees belonging to the age group of 40–49 are less satisfied with their work than employees from 30–39 years. Also, nurses with the most years of experience have statistically lower job satisfaction in terms of extrinsic job characteristics than groups with less work experience. Finally, nurses with more children are less satisfied with their work than those with fewer. Conclusion: Definitions of job satisfaction include a global affective approach with an approach to determine the overall level of job satisfaction while taking into account different individual and organizational factors that influence nurses’ job satisfaction. Contributions to Practice: The findings of this study can contribute to the improvement of working conditions and factors affecting the job satisfaction of intensive care unit nurses.
{"title":"Professional Satisfaction of Nurses in the Intensive Care Unit Environment","authors":"Anastasios Tzenalis, Maria Giouldouri, George Kipourgos, George Elesnitsalis","doi":"10.24018/clinicmed.2023.4.5.293","DOIUrl":"https://doi.org/10.24018/clinicmed.2023.4.5.293","url":null,"abstract":"Background: Job satisfaction of nurses is an issue that has focused intense attention in recent years, mainly due to the widespread reduction, worldwide, in the number of nursing personnel. Purpose to investigate the influence of the work environment of the intensive care unit on nurses and to identify the factors that play a decisive role in job satisfaction. Materials and Methods: Our study involved 100 intensive care unit nurses who completed a questionnaire focusing on nurses’ job satisfaction. Tests used are T-test, Mann-Whitney U (test of two independent samples), Anova, KruskalWallis to test distributions. The non-parametric tests analyzed with two independent variables T-test, Anova, Pearson, one-sample t-Test respectively. Results: Employees belonging to the age group of 40–49 are less satisfied with their work than employees from 30–39 years. Also, nurses with the most years of experience have statistically lower job satisfaction in terms of extrinsic job characteristics than groups with less work experience. Finally, nurses with more children are less satisfied with their work than those with fewer. Conclusion: Definitions of job satisfaction include a global affective approach with an approach to determine the overall level of job satisfaction while taking into account different individual and organizational factors that influence nurses’ job satisfaction. Contributions to Practice: The findings of this study can contribute to the improvement of working conditions and factors affecting the job satisfaction of intensive care unit nurses.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135294503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lysosomal storage disorders (LSD) are a family of genetic diseases that have a devastating impact on the patient and family with a concomitant health burden. These are inherited in an autosomal recessive or, in some cases, in an X-linked manner. Due to the variability of LSD phenotypes, the clinical characteristics of LSD are also heterogeneous. A hospital-based cross-sectional study was conducted at Department of Pediatric Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from July 2022 to June 2022 to explore clinical & laboratory profile of various forms of childhood Lysosomal storage disorders. A total of 59 suspected children of Lysosomal storage disorders (LSD), admitted to hospital during the study period, were included in this study. Among them, 55 cases were diagnosed as Lysosomal storage disorders on the basis of clinical suspicion, biochemical testing and neuroimaging study, and in few cases bone marrow study and molecular genetic testing. Mucopolysaccharidosis 24 (43.64%) and metachromatic leukodystrophy 12 (21.82%) were the most common among all lysosomal storage disorders in our study. Neuroregression 26 (47.27%), microcephaly, and dysmorphism were predominant clinical features. Abnormal neuroimaging changes were found in two-thirds 37 (67.27%) of the cases. Among them, periventricular demyelination 12 (21.82%) and cerebral atrophy 6 (10.91%) were common imaging changes in this study.
{"title":"Pattern of Presentation of Lysosomal Storage Disease in Tertiary Care Hospital of Bangladesh","authors":"Gopen Kumar Kundu, Mohammad Arbab Sarker, Gulsan-Ara Zahan, Ishrat Zahan Nigar","doi":"10.24018/clinicmed.2023.4.5.300","DOIUrl":"https://doi.org/10.24018/clinicmed.2023.4.5.300","url":null,"abstract":"Lysosomal storage disorders (LSD) are a family of genetic diseases that have a devastating impact on the patient and family with a concomitant health burden. These are inherited in an autosomal recessive or, in some cases, in an X-linked manner. Due to the variability of LSD phenotypes, the clinical characteristics of LSD are also heterogeneous. A hospital-based cross-sectional study was conducted at Department of Pediatric Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from July 2022 to June 2022 to explore clinical & laboratory profile of various forms of childhood Lysosomal storage disorders. A total of 59 suspected children of Lysosomal storage disorders (LSD), admitted to hospital during the study period, were included in this study. Among them, 55 cases were diagnosed as Lysosomal storage disorders on the basis of clinical suspicion, biochemical testing and neuroimaging study, and in few cases bone marrow study and molecular genetic testing. Mucopolysaccharidosis 24 (43.64%) and metachromatic leukodystrophy 12 (21.82%) were the most common among all lysosomal storage disorders in our study. Neuroregression 26 (47.27%), microcephaly, and dysmorphism were predominant clinical features. Abnormal neuroimaging changes were found in two-thirds 37 (67.27%) of the cases. Among them, periventricular demyelination 12 (21.82%) and cerebral atrophy 6 (10.91%) were common imaging changes in this study.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136099030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-19DOI: 10.24018/clinicmed.2023.4.5.299
Bernard Terkimbi Utoo, Aliyu Usman El-Nafaty, Chris Emmanuel Nwobodo, Suleiman Yahya, Patrick Joseph Guzol, Bello Ahmadu, Mamman Tijani
Background: Efforts are being made to promote mother and child survival by reducing the high rate of maternal and newborn morbidities in developing nations, particularly in sub-Sahara Africa. The study was designed to find the pattern and associated factors of maternal and newborn morbidities in Gombe, northeast Nigeria test. Materials and Methods: Patients were prospectively interviewed with the use of a structured questionnaire and medical case records were also reviewed. Data obtained was entered into SPSS version 21 for analysis. Results: A total of 250 women were studied. Most (53.6%) were aged 26–35 years. The majority (97.2%) were married. Most (40.0%) were unemployed and of the Fulani ethnicity (36.4%). Urban dwellers were in the majority (55.2%). Approx. 78% had at least a secondary level of education. Most (64.4%) were multiparous, had 2 or more living children (72%), and 76% with less than 8 ANC visits. Distribution of MOD showed C/S (52.4%), SVD (36%), and Instrumental delivery (1.6%). Maternal morbidity was recorded in 22% with PPH (47.3%), Genital injury (30.5%), and Genital sepsis (16.4%) most common. Newborn morbidity was recorded in 23.6% with neonatal asphyxia (25.4%), neonatal jaundice (25.4%), and LBW (22%) most common. Women who had less than 8 ANC visits (p = 0.05) and underwent instrumental delivery (p = 0.002) were more likely to suffer morbidity. Those who had Caesarean Section were less likely to have a maternal morbidity (p = 0.002). Whereas, neonates born to primiparous women were more likely to suffer a morbidity (p = 0.042). There was no significant relationship between number of ANC visits (p = 0.512) and MOD (p = 0.680). Conclusion: PPH, genital injuries, and genital sepsis were the commonest maternal morbidities while Neonatal asphyxia, jaundice, and LBW were commonest in the newborn. Less than eight ANC visits and instrumental delivery increased the likelihood of maternal morbidity, while delivery to primiparous mothers increased the likelihood of newborn morbidity. Campaign for adequate antenatal care clinic visits should be sustained and when indicated cesarean delivery should not be denied to women. Accouchers must be trained in the usage of instrumental deliveries to reduce morbidities associated with it.
{"title":"Maternal and Newborn Morbidity in Federal Teaching Hospital Gombe, North-East, Nigeria","authors":"Bernard Terkimbi Utoo, Aliyu Usman El-Nafaty, Chris Emmanuel Nwobodo, Suleiman Yahya, Patrick Joseph Guzol, Bello Ahmadu, Mamman Tijani","doi":"10.24018/clinicmed.2023.4.5.299","DOIUrl":"https://doi.org/10.24018/clinicmed.2023.4.5.299","url":null,"abstract":"Background: Efforts are being made to promote mother and child survival by reducing the high rate of maternal and newborn morbidities in developing nations, particularly in sub-Sahara Africa. The study was designed to find the pattern and associated factors of maternal and newborn morbidities in Gombe, northeast Nigeria test. Materials and Methods: Patients were prospectively interviewed with the use of a structured questionnaire and medical case records were also reviewed. Data obtained was entered into SPSS version 21 for analysis. Results: A total of 250 women were studied. Most (53.6%) were aged 26–35 years. The majority (97.2%) were married. Most (40.0%) were unemployed and of the Fulani ethnicity (36.4%). Urban dwellers were in the majority (55.2%). Approx. 78% had at least a secondary level of education. Most (64.4%) were multiparous, had 2 or more living children (72%), and 76% with less than 8 ANC visits. Distribution of MOD showed C/S (52.4%), SVD (36%), and Instrumental delivery (1.6%). Maternal morbidity was recorded in 22% with PPH (47.3%), Genital injury (30.5%), and Genital sepsis (16.4%) most common. Newborn morbidity was recorded in 23.6% with neonatal asphyxia (25.4%), neonatal jaundice (25.4%), and LBW (22%) most common. Women who had less than 8 ANC visits (p = 0.05) and underwent instrumental delivery (p = 0.002) were more likely to suffer morbidity. Those who had Caesarean Section were less likely to have a maternal morbidity (p = 0.002). Whereas, neonates born to primiparous women were more likely to suffer a morbidity (p = 0.042). There was no significant relationship between number of ANC visits (p = 0.512) and MOD (p = 0.680). Conclusion: PPH, genital injuries, and genital sepsis were the commonest maternal morbidities while Neonatal asphyxia, jaundice, and LBW were commonest in the newborn. Less than eight ANC visits and instrumental delivery increased the likelihood of maternal morbidity, while delivery to primiparous mothers increased the likelihood of newborn morbidity. Campaign for adequate antenatal care clinic visits should be sustained and when indicated cesarean delivery should not be denied to women. Accouchers must be trained in the usage of instrumental deliveries to reduce morbidities associated with it.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135108947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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