组织工程在生长板软骨再生:机制和治疗策略。

IF 6.7 1区 工程技术 Q1 CELL & TISSUE ENGINEERING Journal of Tissue Engineering Pub Date : 2023-01-01 DOI:10.1177/20417314231187956
Ruoyi Guo, Hanjie Zhuang, Xiuning Chen, Yulong Ben, Minjie Fan, Yiwei Wang, Pengfei Zheng
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引用次数: 0

摘要

生长板损伤的修复是一个高度复杂的过程,涉及多种细胞类型的精确时空调控。虽然在了解生长板损伤的病理机制方面取得了重大进展,但有效调节这一过程以使受伤的生长板软骨再生仍然是一个挑战。组织工程技术作为一种很有前途的治疗方法,通过使用功能性生物材料、种子细胞和生物因子来实现组织再生,目前已广泛应用于骨和软骨的再生。然而,由于生长板软骨独特的结构和功能,需要不同的策略来实现有效的再生。因此,本文就组织工程促进生长板再生的研究现状作一综述。旨在阐明组织工程促进生长板再生的潜在机制,并为未来生长板再生的研究提供新的见解和治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Tissue engineering in growth plate cartilage regeneration: Mechanisms to therapeutic strategies.

The repair of growth plate injuries is a highly complex process that involves precise spatiotemporal regulation of multiple cell types. While significant progress has been made in understanding the pathological mechanisms underlying growth plate injuries, effectively regulating this process to regenerate the injured growth plate cartilage remains a challenge. Tissue engineering technology has emerged as a promising therapeutic approach for achieving tissue regeneration through the use of functional biological materials, seed cells and biological factors, and it is now widely applied to the regeneration of bone and cartilage. However, due to the unique structure and function of growth plate cartilage, distinct strategies are required for effective regeneration. Thus, this review provides an overview of current research on the application of tissue engineering to promote growth plate regeneration. It aims to elucidates the underlying mechanisms by which tissue engineering promotes growth plate regeneration and to provide novel insights and therapeutic strategies for future research on the regeneration of growth plate.

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来源期刊
Journal of Tissue Engineering
Journal of Tissue Engineering Engineering-Biomedical Engineering
CiteScore
11.60
自引率
4.90%
发文量
52
审稿时长
12 weeks
期刊介绍: The Journal of Tissue Engineering (JTE) is a peer-reviewed, open-access journal dedicated to scientific research in the field of tissue engineering and its clinical applications. Our journal encompasses a wide range of interests, from the fundamental aspects of stem cells and progenitor cells, including their expansion to viable numbers, to an in-depth understanding of their differentiation processes. Join us in exploring the latest advancements in tissue engineering and its clinical translation.
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