智力多基因分数更能预测结晶测量结果:青少年大脑认知发展(ABCD)研究的证据。

IF 4.8 1区 心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY Psychological Science Pub Date : 2023-06-01 Epub Date: 2023-05-05 DOI:10.1177/09567976231160702
Robert J Loughnan, Clare E Palmer, Wesley K Thompson, Anders M Dale, Terry L Jernigan, Chun Chieh Fan
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引用次数: 0

摘要

对成人的研究结果表明,与流体智力测验相比,对文化更为敏感的固化智力测验具有更大的遗传性;然而,在儿童身上却没有发现这些结果。本研究使用了青少年大脑认知发展(ABCD)研究中 8518 名 9 至 11 岁参与者的数据。我们发现,智力测验成绩的多基因预测因子(基于对 269,867 人的数据进行的全基因组关联荟萃分析)和教育程度的多基因预测因子(基于 110 万人的数据)可预测神经认知成绩。我们发现,与流体测量相比,结晶测量与这两个多基因预测因子的相关性更强。这反映了之前报道的成人遗传性差异,并表明在儿童中也存在类似的关联。这可能与基因-环境相关性在固化智力测验所测量的认知发展中的突出作用相一致。环境和经验中介因素可能是改善认知结果的可塑目标。
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Intelligence Polygenic Score Is More Predictive of Crystallized Measures: Evidence From the Adolescent Brain Cognitive Development (ABCD) Study.

Findings in adults have shown that crystallized measures of intelligence, which are more culturally sensitive than fluid intelligence measures, have greater heritability; however, these results have not been found in children. The present study used data from 8,518 participants between 9 and 11 years old from the Adolescent Brain Cognitive Development (ABCD) Study. We found that polygenic predictors of intelligence test performance (based on genome-wide association meta-analyses of data from 269,867 individuals) and of educational attainment (based on data from 1.1 million individuals) predicted neurocognitive performance. We found that crystallized measures were more strongly associated with both polygenic predictors than were fluid measures. This mirrored heritability differences reported previously in adults and suggests similar associations in children. This may be consistent with a prominent role of gene-environment correlation in cognitive development measured by crystallized intelligence tests. Environmental and experiential mediators may represent malleable targets for improving cognitive outcomes.

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来源期刊
Psychological Science
Psychological Science PSYCHOLOGY, MULTIDISCIPLINARY-
CiteScore
13.30
自引率
0.00%
发文量
156
期刊介绍: Psychological Science, the flagship journal of The Association for Psychological Science (previously the American Psychological Society), is a leading publication in the field with a citation ranking/impact factor among the top ten worldwide. It publishes authoritative articles covering various domains of psychological science, including brain and behavior, clinical science, cognition, learning and memory, social psychology, and developmental psychology. In addition to full-length articles, the journal features summaries of new research developments and discussions on psychological issues in government and public affairs. "Psychological Science" is published twelve times annually.
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