酒精使用障碍患者酒精戒断期间BDNF CpG甲基化和血清水平的变化:一项初步研究

IF 3 4区医学 Q2 PSYCHIATRY World Journal of Biological Psychiatry Pub Date : 2023-11-01 Epub Date: 2023-08-09 DOI:10.1080/15622975.2023.2242924

Aurélie Lacroix, Nicolas Ramoz, Murielle Girard, Brigitte Plansont, Daphnée Poupon, Philip Gorwood, Philippe Nubukpo

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引用次数: 0

摘要

目的:脑源性神经营养因子(BDNF)水平在包括酒精使用障碍(AUD)在内的各种情况下变化。我们的目标是找出这些变化的驱动因素。方法:12例AUD患者在住院时和4个月后进行酒精戒断评估。我们寻找血清BDNF水平变化与以下因素之间的关系:(1)戒断时间;(2)焦虑(汉密尔顿焦虑量表)和抑郁(贝克抑郁量表);(3)一种功能性BDNF基因型(rs6265); (4) BDNF基因内12个CpG位点(位于外显子I、IV和IX)的甲基化水平。结果:在戒断期间，血清BDNF水平升高。这种增加与BDNF基因甲基化水平的变化有关，更具体地说，是外显子i。我们发现禁欲时间、rs6265、抑郁或焦虑对血清BDNF水平没有显著影响。结论:BDNF基因的表观遗传调控可能参与了与戒酒相关的BDNF血液水平的变化。

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BDNF CpG methylation and serum levels covary during alcohol withdrawal in patients with alcohol use disorder: A pilot study.

Objectives: Brain-derived neurotrophic factor (BDNF) levels vary in various conditions including alcohol use disorder (AUD). We aimed to identify drivers of these variations.

Methods: Twelve patients with AUD were assessed at hospitalisation for alcohol withdrawal and four months later. We looked for associations between the change in serum BDNF levels and (1) length of abstinence, (2) anxiety (Hamilton Anxiety Scale) and depression (Beck-Depression Inventory), (3) one functional BDNF genotype (rs6265) and (4) methylation levels of 12 CpG sites within the BDNF gene (located in exons I, IV and IX).

Results: While abstinence remained, serum BDNF level increased. This increase correlated with the variation of methylation levels of the BDNF gene, and more specifically of exon I. We found no significant effect of length of abstinence, rs6265, depression or anxiety on serum BDNF level.

Conclusions: Epigenetic regulation of the BDNF gene may be involved in variations of BDNF blood level associated with alcohol abstinence.

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来源期刊

World Journal of Biological Psychiatry 医学-精神病学

CiteScore

7.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of The World Journal of Biological Psychiatry is to increase the worldwide communication of knowledge in clinical and basic research on biological psychiatry. Its target audience is thus clinical psychiatrists, educators, scientists and students interested in biological psychiatry. The composition of The World Journal of Biological Psychiatry , with its diverse categories that allow communication of a great variety of information, ensures that it is of interest to a wide range of readers. The World Journal of Biological Psychiatry is a major clinically oriented journal on biological psychiatry. The opportunity to educate (through critical review papers, treatment guidelines and consensus reports), publish original work and observations (original papers and brief reports) and to express personal opinions (Letters to the Editor) makes The World Journal of Biological Psychiatry an extremely important medium in the field of biological psychiatry all over the world.