催产素治疗兴奋剂使用障碍的有效性:一项系统综述。

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES Behavioural Pharmacology Pub Date : 2023-10-01 Epub Date: 2023-07-11 DOI:10.1097/FBP.0000000000000744
Stephen Lee-Cheong, Sacha A Ludgate, Tanisse C M Epp, Christian G Schütz
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引用次数: 0

摘要

目的:本综述的目的是检验催产素在该患者群体中有效性的人类研究证据。尽管兴奋剂使用障碍是一个主要的公共卫生问题,但还没有经过验证的药物治疗方法。心理社会干预的效果有限,尤其是在更严重的兴奋剂使用障碍病例中,而动物模型表明催产素可能是一种有用的治疗方法。方法:采用Medline、Embase和PsychInfo进行文献检索。搜索结果随后被导入Covidence,以确定相关研究。结果:本综述包括六项研究,其中两项为试点研究。尽管催产素在所有研究中都有很好的耐受性,但没有任何研究显示报告的可卡因使用或渴求量在统计学上显著减少。一项研究表明,催产素会增加使用可卡因的欲望,尽管应该考虑参与者的群体。相比之下,一项研究显示,自我报告的可卡因使用量有减少的趋势。结论:现有研究不支持使用催产素治疗兴奋剂使用障碍;然而,纳入的研究样本量小,数量有限。有几个值得注意的发现与本综述的主要和次要结果无关,值得关注,值得进一步研究。我们为这一研究领域的未来研究提供建议。考虑到目前可用的数据有限,在对催产素在兴奋剂使用障碍管理中的使用做出任何明确结论之前,还需要进一步的研究。
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The effectiveness of oxytocin in the treatment of stimulant use disorders: a systematic review.

Objectives: The purpose of this review is to examine human study evidence on the effectiveness of oxytocin in this patient population. Despite stimulant use disorder being a major public health concern, there are no validated pharmacological treatments. Psychosocial interventions show limited effectiveness especially in the more severe cases of stimulant use disorder, whereas animal models suggest that oxytocin may be a useful treatment.

Methods: A literature search using Medline, Embase, and PsychInfo was undertaken. Search results were subsequently imported into Covidence to identify relevant studies.

Results: Six studies were included in this review, two of which were pilot studies. Although oxytocin was well tolerated across studies, no study showed a statistically significant reduction in reported cocaine use or cravings. One study suggested oxytocin increased the desire to use cocaine, although the population of participants should be taken into consideration. In contrast, one study showed a trend towards reduced self-reported cocaine use.

Conclusion: Available research does not support the use of oxytocin in the management of stimulant use disorder; however, included studies are small in sample size and limited in number. There were several noteworthy findings unrelated to this review's primary and secondary outcomes, which are of interest and warrant further research. We provide suggestions for future studies in this area of research. Considering the limited data available at this time, further studies are required before any definitive conclusions can be made regarding the use of oxytocin in stimulant use disorder management.

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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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