{"title":"在曼谷的一个三级保健中心，感染艾滋病毒的青少年和年轻人从儿科转到成人护理的结果。","authors":"Supattra Rungmaitree, Nuchanat Thamniamdee, Saranya Sachdev, Wanatpreeya Phongsamart, Keswadee Lapphra, Orasri Wittawatmongkol, Alan Maleesatharn, Benjawan Khumcha, Risa M Hoffman, Kulkanya Chokephaibulkit","doi":"10.1177/23259582221143673","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> Adolescents and young adults with HIV (AYHIV) are at high-risk of loss to follow up and virologic failure, particularly during transition from pediatric to adult clinics. <b>Methods:</b> We reviewed the medical records of AYHIV to characterize retention and virologic suppression following their transition. <b>Results:</b> 101 AYHIV, 97% perinatally infected, were transferred at the median age of 20 (IQR: 19-21) years. At 1-year post-transition, 92.1% were retained in care and 73.3% had viral suppression and at 2-years the retention and viral suppression were 87.1% and 76.7%, respectively. Factors associated with viral suppression were transition at ≥ 20 years of age (aOR 4.38, 95% CI 1.41-13.65) and receiving first-line ART regimen, compared to second- or third-line regimens, at transition (aOR 6.05, 95% CI 1.55-23.58). <b>Conclusion:</b> Transition outcomes of AYHIV in our setting were suboptimal. There is a need for interventions to support AYHIV transition during this vulnerable period.</p>","PeriodicalId":17328,"journal":{"name":"Journal of the International Association of Providers of AIDS Care","volume":"21 ","pages":"23259582221143673"},"PeriodicalIF":2.2000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/bd/10.1177_23259582221143673.PMC9732801.pdf","citationCount":"0","resultStr":"{\"title\":\"The Outcomes of Transition from Pediatrics to Adult Care among Adolescents and Young Adults with HIV at a Tertiary Care Center in Bangkok.\",\"authors\":\"Supattra Rungmaitree, Nuchanat Thamniamdee, Saranya Sachdev, Wanatpreeya Phongsamart, Keswadee Lapphra, Orasri Wittawatmongkol, Alan Maleesatharn, Benjawan Khumcha, Risa M Hoffman, Kulkanya Chokephaibulkit\",\"doi\":\"10.1177/23259582221143673\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Background:</b> Adolescents and young adults with HIV (AYHIV) are at high-risk of loss to follow up and virologic failure, particularly during transition from pediatric to adult clinics. <b>Methods:</b> We reviewed the medical records of AYHIV to characterize retention and virologic suppression following their transition. <b>Results:</b> 101 AYHIV, 97% perinatally infected, were transferred at the median age of 20 (IQR: 19-21) years. At 1-year post-transition, 92.1% were retained in care and 73.3% had viral suppression and at 2-years the retention and viral suppression were 87.1% and 76.7%, respectively. Factors associated with viral suppression were transition at ≥ 20 years of age (aOR 4.38, 95% CI 1.41-13.65) and receiving first-line ART regimen, compared to second- or third-line regimens, at transition (aOR 6.05, 95% CI 1.55-23.58). <b>Conclusion:</b> Transition outcomes of AYHIV in our setting were suboptimal. There is a need for interventions to support AYHIV transition during this vulnerable period.</p>\",\"PeriodicalId\":17328,\"journal\":{\"name\":\"Journal of the International Association of Providers of AIDS Care\",\"volume\":\"21 \",\"pages\":\"23259582221143673\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/bd/10.1177_23259582221143673.PMC9732801.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the International Association of Providers of AIDS Care\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/23259582221143673\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the International Association of Providers of AIDS Care","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/23259582221143673","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
摘要
背景:感染艾滋病毒(AYHIV)的青少年和年轻成人处于随访失败和病毒学失败的高风险中，特别是在从儿科到成人诊所的过渡期间。方法:我们回顾了AYHIV的医疗记录，以表征其转移后的保留和病毒学抑制。结果:101例AYHIV, 97%围生期感染，中位年龄为20岁(IQR: 19-21)。转换后1年，92.1%的患者仍在护理中，73.3%的患者病毒抑制，2年的患者保留率和病毒抑制率分别为87.1%和76.7%。与病毒抑制相关的因素是≥20岁时的转移(aOR 4.38, 95% CI 1.41-13.65)，以及与二线或三线方案相比，在转移时接受一线ART方案(aOR 6.05, 95% CI 1.55-23.58)。结论:在我们的环境中，AYHIV的过渡结局不是最理想的。在这一脆弱时期，有必要采取干预措施，支持艾滋病病毒的过渡。
The Outcomes of Transition from Pediatrics to Adult Care among Adolescents and Young Adults with HIV at a Tertiary Care Center in Bangkok.
Background: Adolescents and young adults with HIV (AYHIV) are at high-risk of loss to follow up and virologic failure, particularly during transition from pediatric to adult clinics. Methods: We reviewed the medical records of AYHIV to characterize retention and virologic suppression following their transition. Results: 101 AYHIV, 97% perinatally infected, were transferred at the median age of 20 (IQR: 19-21) years. At 1-year post-transition, 92.1% were retained in care and 73.3% had viral suppression and at 2-years the retention and viral suppression were 87.1% and 76.7%, respectively. Factors associated with viral suppression were transition at ≥ 20 years of age (aOR 4.38, 95% CI 1.41-13.65) and receiving first-line ART regimen, compared to second- or third-line regimens, at transition (aOR 6.05, 95% CI 1.55-23.58). Conclusion: Transition outcomes of AYHIV in our setting were suboptimal. There is a need for interventions to support AYHIV transition during this vulnerable period.
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