COVID-19患者由新丝胞菌引起的褐丝酵母菌病

IF 1.5 4区生物学 Q4 MYCOLOGY Revista Iberoamericana De Micologia Pub Date : 2022-07-01 DOI:10.1016/j.riam.2022.07.002

Somayeh Dolatabadi , Sara Nasirharandi , Morteza Pourahmad , Kazem Ahmadikia , Mojgan Mokhtari , Mohammad Javad Najafzadeh , Rasoul Mohammadi

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引用次数: 1

摘要

背景:neoscytalidium dimidiatum是一种机会性真菌，隶属于dothideomycates纲。病例报告我们报告1例来自伊朗的32岁男性患者在COVID-19感染后出现双斑棘球蚴脑褐丝酵母菌病。通过细胞病理学、常规真菌学方法和rDNA内部转录间隔区(ITS)的DNA测序来鉴定病原体。除了COVID-19并发症和皮质类固醇治疗外，未诊断出任何潜在疾病。这些症状表明真菌感染是在出院两周后出现的。脑部核磁共振显示多灶性中枢神经系统感染。真菌的延迟鉴定，因此，用两性霉素B抗真菌治疗的延迟开始，可能影响了患者最终死亡的结果。结论本病例感染发生率低，应引起重视，及时进行抗真菌治疗。

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Phaeohyphomycosis caused by Neoscytalidium dimidiatum in a COVID-19 patient

Background

Neoscytalidium dimidiatum is an opportunistic dematiaceous fungus belonging to the class Dothideomycetes.

Case report

We report a case of N. dimidiatum cerebral phaeohyphomycosis post COVID-19 infection in a 32-year-old male from Iran. The causative agent was identified by cytopathology, routine mycological methods, and DNA sequencing of the internal transcribed spacer (ITS) region of rDNA. Apart from COVID-19 complications and the corticosteroid therapy, no underlying condition was diagnosed. The symptoms suggesting the fungal infection were shown two weeks after being discharged from COVID-19 hospital stay. Magnetic resonance of the brain showed a multi-focal central nervous system infection. The delayed identification of the fungus and, thus, a late starting of the antifungal treatment with amphotericin B, might have affected the patient outcome as he finally died.

Conclusions

Considering the rare incidence of N. dimidiatum infections, this case should aware us about them, leading to a timely antifungal management.

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来源期刊

Revista Iberoamericana De Micologia MYCOLOGY-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

81 days

期刊介绍： Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.