全年龄哮喘队列(ALLIANCE)哮喘和喘息儿童的呼吸萘增加。

IF 3.7 4区 医学 Q1 BIOCHEMICAL RESEARCH METHODS Journal of breath research Pub Date : 2023-10-12 DOI:10.1088/1752-7163/acf23e
Pedram Shahrokny, Nicole Maison, Lennart Riemann, Maximilian Ehrmann, David DeLuca, Sven Schuchardt, Dominik Thiele, Markus Weckmann, Anna-Maria Dittrich, Bianca Schaub, Folke Brinkmann, Gesine Hansen, Matthias Kopp, Erika von Mutius, Klaus Rabe, Thomas Bahmer, Jens Hohlfeld, Ruth Grychtol, Olaf Holz
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引用次数: 0

摘要

呼气中含有大量挥发性有机化合物(VOC),已知与哮喘等肺部疾病有关。它的收集是非侵入性的,操作简单,因此即使在幼儿中也很有吸引力。我们分析了多中心全年龄哮喘队列(ALLIANCE)儿童的呼吸,以评估“呼吸困难”是否有可能使哮喘和喘息患者表型,并确定潜在疾病机制的外部风险因素。从142名儿童(哮喘:51名,学龄前喘息者:55名,健康对照组:36名)采集呼吸样本,并使用气相色谱-质谱法(GC/MS)进行分析。儿童根据全球哮喘倡议指南进行诊断,并在长达七年的时间里每年进行全面检查。40名儿童在24或48个月后重复呼吸采集。大多数不同组的呼吸挥发性有机物反映了儿童的暴露情况。我们观察到,在哮喘或喘息的儿童中,与生活方式相关的挥发性有机物含量较低,环境污染物含量较高,尤其是萘。萘在有症状的患者和最近吸入皮质类固醇的喘息者中也较高。未检测到与肺功能或TH2炎症的关系。哮喘患者和喘息者萘含量的增加以及与疾病严重程度的关系可能表明环境或室内空气污染在哮喘的发展或进展中发挥了作用。呼吸挥发性有机物可能有助于阐明暴露体在哮喘发展中的作用。该研究已在ClinicalTrials.gov上注册(NCT02496468)。
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Increased breath naphthalene in children with asthma and wheeze of the All Age Asthma Cohort (ALLIANCE).

Exhaled breath contains numerous volatile organic compounds (VOCs) known to be related to lung disease like asthma. Its collection is non-invasive, simple to perform and therefore an attractive method for the use even in young children. We analysed breath in children of the multicenter All Age Asthma Cohort (ALLIANCE) to evaluate if 'breathomics' have the potential to phenotype patients with asthma and wheeze, and to identify extrinsic risk factors for underlying disease mechanisms. A breath sample was collected from 142 children (asthma: 51, pre-school wheezers: 55, healthy controls: 36) and analysed using gas chromatography-mass spectrometry (GC/MS). Children were diagnosed according to Global Initiative for Asthma guidelines and comprehensively examined each year over up to seven years. Forty children repeated the breath collection after 24 or 48 months. Most breath VOCs differing between groups reflect the exposome of the children. We observed lower levels of lifestyle-related VOCs and higher levels of the environmental pollutants, especially naphthalene, in children with asthma or wheeze. Naphthalene was also higher in symptomatic patients and in wheezers with recent inhaled corticosteroid use. No relationships with lung function or TH2 inflammation were detected. Increased levels of naphthalene in asthmatics and wheezers and the relationship to disease severity could indicate a role of environmental or indoor air pollution for the development or progress of asthma. Breath VOCs might help to elucidate the role of the exposome for the development of asthma. The study was registered at ClinicalTrials.gov (NCT02496468).

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来源期刊
Journal of breath research
Journal of breath research BIOCHEMICAL RESEARCH METHODS-RESPIRATORY SYSTEM
CiteScore
7.60
自引率
21.10%
发文量
49
审稿时长
>12 weeks
期刊介绍: Journal of Breath Research is dedicated to all aspects of scientific breath research. The traditional focus is on analysis of volatile compounds and aerosols in exhaled breath for the investigation of exogenous exposures, metabolism, toxicology, health status and the diagnosis of disease and breath odours. The journal also welcomes other breath-related topics. Typical areas of interest include: Big laboratory instrumentation: describing new state-of-the-art analytical instrumentation capable of performing high-resolution discovery and targeted breath research; exploiting complex technologies drawn from other areas of biochemistry and genetics for breath research. Engineering solutions: developing new breath sampling technologies for condensate and aerosols, for chemical and optical sensors, for extraction and sample preparation methods, for automation and standardization, and for multiplex analyses to preserve the breath matrix and facilitating analytical throughput. Measure exhaled constituents (e.g. CO2, acetone, isoprene) as markers of human presence or mitigate such contaminants in enclosed environments. Human and animal in vivo studies: decoding the ''breath exposome'', implementing exposure and intervention studies, performing cross-sectional and case-control research, assaying immune and inflammatory response, and testing mammalian host response to infections and exogenous exposures to develop information directly applicable to systems biology. Studying inhalation toxicology; inhaled breath as a source of internal dose; resultant blood, breath and urinary biomarkers linked to inhalation pathway. Cellular and molecular level in vitro studies. Clinical, pharmacological and forensic applications. Mathematical, statistical and graphical data interpretation.
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