含异腈和炔烃天然产物的生物合成。

IF 7.6 2区 工程技术 Q1 CHEMISTRY, APPLIED Annual review of chemical and biomolecular engineering Pub Date : 2022-06-10 Epub Date: 2022-03-02 DOI:10.1146/annurev-chembioeng-092120-025140
Antonio Del Rio Flores, Colin C Barber, Maanasa Narayanamoorthy, Di Gu, Yuanbo Shen, Wenjun Zhang
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引用次数: 0

摘要

天然产物是一类种类繁多的生物化合物,参与细胞信号传递、营养获取和干扰竞争等基本生物过程。异腈和炔烃等独特的三键官能团通常具有生物活性,可作为新型化学逻辑和酶机制的指标。然而,人们对这些官能团的生物合成基础仍然只有部分了解,这限制了合理设计具有这些官能团的生物大分子以应用于制药、生物正交化学和其他增值化学过程的机会。在此,我们将重点回顾异腈和炔烃官能团的特征生物合成途径、它们的生物正交转化,以及将它们的生物合成机制工程化用于生物技术应用的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Biosynthesis of Isonitrile- and Alkyne-Containing Natural Products.

Natural products are a diverse class of biologically produced compounds that participate in fundamental biological processes such as cell signaling, nutrient acquisition, and interference competition. Unique triple-bond functionalities like isonitriles and alkynes often drive bioactivity and may serve as indicators of novel chemical logic and enzymatic machinery. Yet, the biosynthetic underpinnings of these groups remain only partially understood, constraining the opportunity to rationally engineer biomolecules with these functionalities for applications in pharmaceuticals, bioorthogonal chemistry, and other value-added chemical processes. Here, we focus our review on characterized biosynthetic pathways for isonitrile and alkyne functionalities, their bioorthogonal transformations, and prospects for engineering their biosynthetic machinery for biotechnological applications.

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来源期刊
Annual review of chemical and biomolecular engineering
Annual review of chemical and biomolecular engineering CHEMISTRY, APPLIED-ENGINEERING, CHEMICAL
CiteScore
16.00
自引率
0.00%
发文量
25
期刊介绍: The Annual Review of Chemical and Biomolecular Engineering aims to provide a perspective on the broad field of chemical (and related) engineering. The journal draws from disciplines as diverse as biology, physics, and engineering, with development of chemical products and processes as the unifying theme.
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