百日咳杆菌与外膜囊泡。

IF 4.9 4区 医学 Q1 PARASITOLOGY Pathogens and Global Health Pub Date : 2023-06-01 DOI:10.1080/20477724.2022.2117937
Çiğdem Yilmaz Çolak, Burcu Emine Tefon Öztürk
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引用次数: 0

摘要

百日咳博德泰拉是一种叫做百日咳的呼吸道感染的病原体,对新生儿和婴儿来说是致命的。病原体产生多种抗原化合物,这些抗原化合物可以单独或同时破坏多种宿主细胞。尽管世界各地有百日咳疫苗,并且疫苗接种覆盖率很高,但在许多国家观察到该病死灰复燃。百日咳病例增加的原因可能包括认识的提高、诊断技术的改进、疫苗效力低,特别是无细胞疫苗,以及免疫力下降。为制定更有效的防治百日咳战略已作出许多努力,其中一项战略是在疫苗配方中使用外膜囊泡(omv)。由于omv可以携带毒素和LPS等免疫原性结构,因此作为疫苗平台引起了人们的极大兴趣。对来自不同百日咳菌株的omv进行了许多研究,并在动物挑战和人类临床前模型中显示了有希望的结果。然而,omv的组成在分离和纯化方法、菌株、培养和胁迫条件方面存在差异。尽管百日咳小泡是一种有吸引力的百日咳候选疫苗,但需要进一步的研究来推进下一代百日咳疫苗的临床研究。本文综述了百日咳的一般信息、百日咳疫苗的历史以及对这些疫苗的免疫反应,重点是omv。我们讨论了开发基于omv的百日咳疫苗平台的进展,并强调了成功的应用以及潜在的挑战和差距。
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Bordetella pertussis and outer membrane vesicles.

Bordetella pertussis is the causative agent of a respiratory infection called pertussis (whooping cough) that can be fatal in newborns and infants. The pathogen produces a variety of antigenic compounds which alone or simultaneously can damage various host cells. Despite the availability of pertussis vaccines and high vaccination coverage around the world, a resurgence of the disease has been observed in many countries. Reasons for the increase in pertussis cases may include increased awareness, improved diagnostic techniques, low vaccine efficacy, especially acellular vaccines, and waning immunity. Many efforts have been made to develop more effective strategies to fight against B. pertussis and one of the strategies is the use of outer membrane vesicles (OMVs) in vaccine formulations. OMVs are attracting great interest as vaccine platforms since they can carry immunogenic structures such as toxins and LPS. Many studies have been carried out with OMVs from different B. pertussis strains and they revealed promising results in the animal challenge and human preclinical model. However, the composition of OMVs differs in terms of isolation and purification methods, strains, culture, and stress conditions. Although the vesicles from B. pertussis represent an attractive pertussis vaccine candidate, further studies are needed to advance clinical research for next-generation pertussis vaccines. This review summarizes general information about pertussis, the history of vaccines against the disease, and the immune response to these vaccines, with a focus on OMVs. We discuss progress in developing an OMV-based pertussis vaccine platform and highlight successful applications as well as potential challenges and gaps.

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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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