木犀草素通过AMPK/PGC-1α途径改善小鼠肝脏脂肪变性并促进线粒体生物发生

IF 0.7 4区 医学 Q4 NUTRITION & DIETETICS Journal of nutritional science and vitaminology Pub Date : 2023-01-01 DOI:10.3177/jnsv.69.259
Tingting Wang, Qin Xu, Yang Cao, Cheng Zhang, Shiyin Chen, Yun Zhang, Tingbo Liang
{"title":"木犀草素通过AMPK/PGC-1α途径改善小鼠肝脏脂肪变性并促进线粒体生物发生","authors":"Tingting Wang,&nbsp;Qin Xu,&nbsp;Yang Cao,&nbsp;Cheng Zhang,&nbsp;Shiyin Chen,&nbsp;Yun Zhang,&nbsp;Tingbo Liang","doi":"10.3177/jnsv.69.259","DOIUrl":null,"url":null,"abstract":"<p><p>Luteolin (LU), a natural compound, has diverse bioactivities; it alleviates lipid accumulation by enhancing the oxidation of fatty acids in nonalcoholic fatty liver disease (NAFLD). Mitochondrial dysfunction promotes the development of steatosis in NAFLD. However, few studies have focused on the mechanism by which LU affects mitochondrial function in NAFLD. In the present study, we investigated whether LU could ameliorate hepatic steatosis and affect mitochondrial function in Western diet-fed mice. After LU treatment, the indicators of hepatic function and markers of mitochondrial biogenesis were evaluated. The results showed that LU intervention 1) decreased the levels of serum triglyceride, total cholesterol, alanine aminotransferase, and low-density lipoprotein cholesterol; 2) increased the succinate dehydrogenase activity of mitochondrial enzyme; and 3) increased mitochondrial biogenesis by upregulating the AMPK/PGC-1α pathway. Therefore, LU might have the potential to prevent NAFLD.</p>","PeriodicalId":16624,"journal":{"name":"Journal of nutritional science and vitaminology","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Luteolin Ameliorates Hepatic Steatosis and Enhances Mitochondrial Biogenesis via AMPK/PGC-1α Pathway in Western Diet-Fed Mice.\",\"authors\":\"Tingting Wang,&nbsp;Qin Xu,&nbsp;Yang Cao,&nbsp;Cheng Zhang,&nbsp;Shiyin Chen,&nbsp;Yun Zhang,&nbsp;Tingbo Liang\",\"doi\":\"10.3177/jnsv.69.259\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Luteolin (LU), a natural compound, has diverse bioactivities; it alleviates lipid accumulation by enhancing the oxidation of fatty acids in nonalcoholic fatty liver disease (NAFLD). Mitochondrial dysfunction promotes the development of steatosis in NAFLD. However, few studies have focused on the mechanism by which LU affects mitochondrial function in NAFLD. In the present study, we investigated whether LU could ameliorate hepatic steatosis and affect mitochondrial function in Western diet-fed mice. After LU treatment, the indicators of hepatic function and markers of mitochondrial biogenesis were evaluated. The results showed that LU intervention 1) decreased the levels of serum triglyceride, total cholesterol, alanine aminotransferase, and low-density lipoprotein cholesterol; 2) increased the succinate dehydrogenase activity of mitochondrial enzyme; and 3) increased mitochondrial biogenesis by upregulating the AMPK/PGC-1α pathway. Therefore, LU might have the potential to prevent NAFLD.</p>\",\"PeriodicalId\":16624,\"journal\":{\"name\":\"Journal of nutritional science and vitaminology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of nutritional science and vitaminology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3177/jnsv.69.259\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of nutritional science and vitaminology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3177/jnsv.69.259","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0

摘要

木犀草素是一种具有多种生物活性的天然化合物;它通过增强非酒精性脂肪性肝病(NAFLD)中脂肪酸的氧化来减轻脂质积累。线粒体功能障碍促进NAFLD脂肪变性的发生。然而,很少有研究关注LU影响NAFLD线粒体功能的机制。在本研究中,我们研究了LU是否可以改善西方饮食小鼠的肝脏脂肪变性和影响线粒体功能。观察LU治疗后大鼠肝功能指标及线粒体生物发生标志物的变化。结果表明:LU干预1)降低了血清甘油三酯、总胆固醇、丙氨酸转氨酶和低密度脂蛋白胆固醇水平;2)增加线粒体酶琥珀酸脱氢酶活性;3)通过上调AMPK/PGC-1α通路增加线粒体生物发生。因此,LU可能具有预防NAFLD的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Luteolin Ameliorates Hepatic Steatosis and Enhances Mitochondrial Biogenesis via AMPK/PGC-1α Pathway in Western Diet-Fed Mice.

Luteolin (LU), a natural compound, has diverse bioactivities; it alleviates lipid accumulation by enhancing the oxidation of fatty acids in nonalcoholic fatty liver disease (NAFLD). Mitochondrial dysfunction promotes the development of steatosis in NAFLD. However, few studies have focused on the mechanism by which LU affects mitochondrial function in NAFLD. In the present study, we investigated whether LU could ameliorate hepatic steatosis and affect mitochondrial function in Western diet-fed mice. After LU treatment, the indicators of hepatic function and markers of mitochondrial biogenesis were evaluated. The results showed that LU intervention 1) decreased the levels of serum triglyceride, total cholesterol, alanine aminotransferase, and low-density lipoprotein cholesterol; 2) increased the succinate dehydrogenase activity of mitochondrial enzyme; and 3) increased mitochondrial biogenesis by upregulating the AMPK/PGC-1α pathway. Therefore, LU might have the potential to prevent NAFLD.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
1.80
自引率
6.20%
发文量
63
审稿时长
6-12 weeks
期刊介绍: The Journal of Nutritional Science and Vitaminology is an international medium publishing in English of original work in all branches of nutritional science, food science and vitaminology from any country. Manuscripts submitted for publication should be as concise as possible and must be based on the results of original research or of original interpretation of existing knowledge not previously published. Although data may have been reported, in part, in preliminary or abstract form, a full report of such research is unacceptable if it has been or will be submitted for consideration by another journal.
期刊最新文献
A Short-Term Zinc-Deficient Diet Maintains Serum Calcium Concentrations through Ca Absorption-Related Gene Expression in Rats. Antioxidant Vitamin Intake and LOX-Index in Japanese Municipal Workers. Cholesterol-Lowering and Antioxidant Effects of Pork-Liver Protein Hydrolysate in Otsuka Long-Evans Tokushima Fatty Rats. Chronic Ethanol Intake Impairs Niacin Nutritional Status in Mice. Dietary Supplementation with Cholic Acid Reduces Insulin Secretion in Response to Intraperitoneal Glucose Administration in Rats.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1