{"title":"微生物衍生的代谢物抵消肿瘤诱导的免疫抑制和促进免疫检查点封锁。","authors":"Hassane M Zarour","doi":"10.1016/j.cmet.2022.11.010","DOIUrl":null,"url":null,"abstract":"<p><p>The tumor and gut microbiome regulate antitumor immunity and modulate responses to immune checkpoint blockade, although the mechanisms of action remain uncertain. A recent study in Science Immunology by Mirji et al. describes that the microbiota-generated metabolite trimethylamine N-oxide (TMAO) plays a critical role in mediating the effects of the microbiome on antitumor immunity.</p>","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":null,"pages":null},"PeriodicalIF":27.7000,"publicationDate":"2022-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade.\",\"authors\":\"Hassane M Zarour\",\"doi\":\"10.1016/j.cmet.2022.11.010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The tumor and gut microbiome regulate antitumor immunity and modulate responses to immune checkpoint blockade, although the mechanisms of action remain uncertain. A recent study in Science Immunology by Mirji et al. describes that the microbiota-generated metabolite trimethylamine N-oxide (TMAO) plays a critical role in mediating the effects of the microbiome on antitumor immunity.</p>\",\"PeriodicalId\":9840,\"journal\":{\"name\":\"Cell metabolism\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":27.7000,\"publicationDate\":\"2022-12-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell metabolism\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/j.cmet.2022.11.010\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell metabolism","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.cmet.2022.11.010","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade.
The tumor and gut microbiome regulate antitumor immunity and modulate responses to immune checkpoint blockade, although the mechanisms of action remain uncertain. A recent study in Science Immunology by Mirji et al. describes that the microbiota-generated metabolite trimethylamine N-oxide (TMAO) plays a critical role in mediating the effects of the microbiome on antitumor immunity.
期刊介绍：
Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others.
Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.
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