Falcaria vulgaris L。水醇提取物可防止氯化汞对大鼠肾脏的有害影响。

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2023-07-01 DOI:10.22038/AJP.2023.21872
Ali Ghanbari, Cyrus Jalili, Amir Abdolmaleki, Mohsen Zhaleh, Armin Zarinkhat, Nasim Akhshi
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引用次数: 0

摘要

目的:氯化汞(Merc;HgCl2)对人和动物有毒,并造成环境污染,通常会对不同器官造成神经和全身伤害。法尔卡菜是一种富含抗氧化剂的药用植物。本研究旨在评估FV水醇提取物对Merc所致肾毒性的影响。材料和方法:48只雄性大鼠分为8组:对照组:生理盐水;Merc组:接受0.5ml/天的0.5ppm的Merc水溶液;FV1、2和3组:分别接受50、100、150 mg/kg FV;和Merc+FV1、2和3组:接受三个剂量的Merc和FV。给药期为14天。随后,对各组的肾脏和血清进行累积以进行分析。通过苏木精-伊红染色和生化测试对样品进行分析。结果:接受Merc治疗的大鼠肾指数、肾小体直径、总抗氧化能力显著下降,超氧化物歧化酶活性(all,p结论:FV水醇提取物可保护肾脏免受Merc诱导的肾毒性,其抗氧化和抗细胞凋亡的特性参与了这种愈合作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Falcaria vulgaris L. hydroalcoholic extract protects against harmful effects of mercuric chloride on the rat kidney.

Objective: Mercuric chloride (Merc; HgCl2) is toxic to humans and animals and contributes to environmental pollution, which usually results in nerve and systemic harm to different organs. Falcaria vulgaris (FV) is a medicinal plant rich in antioxidants. This research aimed to assess the FV hydroalcoholic extract effects on kidney toxicity induced by Merc.

Materials and methods: Forty-eight male rats were divided into eight groups: the control group: received saline; the Merc group: received 0.5 ml/day of 0.5 ppm aqueous Merc; FV1, 2, and 3 groups: received 50, 100, 150 mg/kg FV, respectively; and Merc + FV1, 2, and 3 groups: received Merc and FV at three doses. The administration period was 14-days. Subsequently, kidneys and sera were cumulated from each group for the analysis. Samples were analyzed via hematoxylin-eosin staining and biochemical tests.

Results: The rats that received Merc displayed significant decrement in the kidney index, the diameter of renal corpuscles, total antioxidant capacity levels, superoxide dismutase activity (all, p<0.01), and 150 mg/kg FV mitigated these outcomes (all, p<0.05). Urea, creatinine, nitric oxide, and the level of apoptosis revealed a significant increment in the kidney of the rats that received Merc (all, p<0.01), and 150 mg/kg FV decreased these results. Furthermore, FV ameliorated histological changes induced by Merc (all, p<0.05).

Conclusion: The FV hydroalcoholic extract protects the kidneys against Merc-induced nephrotoxicity. Antioxidant and anti-apoptotic FV hydroalcoholic extract properties were involved in this healing effect.

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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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