{"title":"贯叶金丝桃提取物和豆蔻提取物联合补充对抑郁症患者的抗抑郁作用:一项随机临床试验。","authors":"Akram Sadeghi, Fatemeh Ghorayshi, Hojjat Baghshahi, Hossein Akbari, Mohammad Reza Memarzadeh, Mohsen Taghizadeh, Alireza Safaei","doi":"10.22038/AJP.2023.21707","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong><i>Echium amoenum</i> and <i>Hypericum perforatum</i> dried flowers have been used for therapy of mental disorders in Iranian traditional medicine. In this study, we assessed the efficacy of the <i>E. amoenum</i> and <i>H. perforatum</i> extracts in patients with mild to moderate depression.</p><p><strong>Materials and methods: </strong>In an 8-week double-blind, parallel-group trial, 51 patients randomly consumed 20 mg of fluoxetine or 350 mg of herbal medicine twice daily. The Hamilton Rating Scale for Depression (HAM-D) was used to assess depression severity in patients at weeks 0, 4, and 8.</p><p><strong>Results: </strong>According to the Hamilton score, there were no significant differences between the fluoxetine- and herbal medicine-treated groups after 4 and 8 weeks (p>0.05). Dry mouth was the only reported side effect which was significantly lower in the herbal group (p<0.05) in weeks 2 and 4.</p><p><strong>Conclusion: </strong><i>E. amoenum</i> and <i>H. perforatum</i> have anti-depressant properties similar to fluoxetine and they can be used to treat depression as an alternative to fluoxetine.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474918/pdf/","citationCount":"0","resultStr":"{\"title\":\"The antidepressant effect of combined extracts of <i>Hypericum perforatum</i> and <i>Echium amoenum</i> supplementation in patients with depression symptoms: A randomized clinical trial.\",\"authors\":\"Akram Sadeghi, Fatemeh Ghorayshi, Hojjat Baghshahi, Hossein Akbari, Mohammad Reza Memarzadeh, Mohsen Taghizadeh, Alireza Safaei\",\"doi\":\"10.22038/AJP.2023.21707\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong><i>Echium amoenum</i> and <i>Hypericum perforatum</i> dried flowers have been used for therapy of mental disorders in Iranian traditional medicine. In this study, we assessed the efficacy of the <i>E. amoenum</i> and <i>H. perforatum</i> extracts in patients with mild to moderate depression.</p><p><strong>Materials and methods: </strong>In an 8-week double-blind, parallel-group trial, 51 patients randomly consumed 20 mg of fluoxetine or 350 mg of herbal medicine twice daily. The Hamilton Rating Scale for Depression (HAM-D) was used to assess depression severity in patients at weeks 0, 4, and 8.</p><p><strong>Results: </strong>According to the Hamilton score, there were no significant differences between the fluoxetine- and herbal medicine-treated groups after 4 and 8 weeks (p>0.05). Dry mouth was the only reported side effect which was significantly lower in the herbal group (p<0.05) in weeks 2 and 4.</p><p><strong>Conclusion: </strong><i>E. amoenum</i> and <i>H. perforatum</i> have anti-depressant properties similar to fluoxetine and they can be used to treat depression as an alternative to fluoxetine.</p>\",\"PeriodicalId\":8677,\"journal\":{\"name\":\"Avicenna Journal of Phytomedicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474918/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Avicenna Journal of Phytomedicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22038/AJP.2023.21707\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Avicenna Journal of Phytomedicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22038/AJP.2023.21707","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
The antidepressant effect of combined extracts of Hypericum perforatum and Echium amoenum supplementation in patients with depression symptoms: A randomized clinical trial.
Objective: Echium amoenum and Hypericum perforatum dried flowers have been used for therapy of mental disorders in Iranian traditional medicine. In this study, we assessed the efficacy of the E. amoenum and H. perforatum extracts in patients with mild to moderate depression.
Materials and methods: In an 8-week double-blind, parallel-group trial, 51 patients randomly consumed 20 mg of fluoxetine or 350 mg of herbal medicine twice daily. The Hamilton Rating Scale for Depression (HAM-D) was used to assess depression severity in patients at weeks 0, 4, and 8.
Results: According to the Hamilton score, there were no significant differences between the fluoxetine- and herbal medicine-treated groups after 4 and 8 weeks (p>0.05). Dry mouth was the only reported side effect which was significantly lower in the herbal group (p<0.05) in weeks 2 and 4.
Conclusion: E. amoenum and H. perforatum have anti-depressant properties similar to fluoxetine and they can be used to treat depression as an alternative to fluoxetine.