贯叶金丝桃提取物和豆蔻提取物联合补充对抑郁症患者的抗抑郁作用:一项随机临床试验。

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2023-07-01 DOI:10.22038/AJP.2023.21707
Akram Sadeghi, Fatemeh Ghorayshi, Hojjat Baghshahi, Hossein Akbari, Mohammad Reza Memarzadeh, Mohsen Taghizadeh, Alireza Safaei
{"title":"贯叶金丝桃提取物和豆蔻提取物联合补充对抑郁症患者的抗抑郁作用:一项随机临床试验。","authors":"Akram Sadeghi,&nbsp;Fatemeh Ghorayshi,&nbsp;Hojjat Baghshahi,&nbsp;Hossein Akbari,&nbsp;Mohammad Reza Memarzadeh,&nbsp;Mohsen Taghizadeh,&nbsp;Alireza Safaei","doi":"10.22038/AJP.2023.21707","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong><i>Echium amoenum</i> and <i>Hypericum perforatum</i> dried flowers have been used for therapy of mental disorders in Iranian traditional medicine. In this study, we assessed the efficacy of the <i>E. amoenum</i> and <i>H. perforatum</i> extracts in patients with mild to moderate depression.</p><p><strong>Materials and methods: </strong>In an 8-week double-blind, parallel-group trial, 51 patients randomly consumed 20 mg of fluoxetine or 350 mg of herbal medicine twice daily. The Hamilton Rating Scale for Depression (HAM-D) was used to assess depression severity in patients at weeks 0, 4, and 8.</p><p><strong>Results: </strong>According to the Hamilton score, there were no significant differences between the fluoxetine- and herbal medicine-treated groups after 4 and 8 weeks (p>0.05). Dry mouth was the only reported side effect which was significantly lower in the herbal group (p<0.05) in weeks 2 and 4.</p><p><strong>Conclusion: </strong><i>E. amoenum</i> and <i>H. perforatum</i> have anti-depressant properties similar to fluoxetine and they can be used to treat depression as an alternative to fluoxetine.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474918/pdf/","citationCount":"0","resultStr":"{\"title\":\"The antidepressant effect of combined extracts of <i>Hypericum perforatum</i> and <i>Echium amoenum</i> supplementation in patients with depression symptoms: A randomized clinical trial.\",\"authors\":\"Akram Sadeghi,&nbsp;Fatemeh Ghorayshi,&nbsp;Hojjat Baghshahi,&nbsp;Hossein Akbari,&nbsp;Mohammad Reza Memarzadeh,&nbsp;Mohsen Taghizadeh,&nbsp;Alireza Safaei\",\"doi\":\"10.22038/AJP.2023.21707\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong><i>Echium amoenum</i> and <i>Hypericum perforatum</i> dried flowers have been used for therapy of mental disorders in Iranian traditional medicine. In this study, we assessed the efficacy of the <i>E. amoenum</i> and <i>H. perforatum</i> extracts in patients with mild to moderate depression.</p><p><strong>Materials and methods: </strong>In an 8-week double-blind, parallel-group trial, 51 patients randomly consumed 20 mg of fluoxetine or 350 mg of herbal medicine twice daily. The Hamilton Rating Scale for Depression (HAM-D) was used to assess depression severity in patients at weeks 0, 4, and 8.</p><p><strong>Results: </strong>According to the Hamilton score, there were no significant differences between the fluoxetine- and herbal medicine-treated groups after 4 and 8 weeks (p>0.05). Dry mouth was the only reported side effect which was significantly lower in the herbal group (p<0.05) in weeks 2 and 4.</p><p><strong>Conclusion: </strong><i>E. amoenum</i> and <i>H. perforatum</i> have anti-depressant properties similar to fluoxetine and they can be used to treat depression as an alternative to fluoxetine.</p>\",\"PeriodicalId\":8677,\"journal\":{\"name\":\"Avicenna Journal of Phytomedicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474918/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Avicenna Journal of Phytomedicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22038/AJP.2023.21707\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Avicenna Journal of Phytomedicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22038/AJP.2023.21707","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0

摘要

目的:在伊朗传统医学中,Echium amoenum和金丝桃干花已被用于治疗精神障碍。在这项研究中,我们评估了埃莫埃姆和穿支埃莫提取物对轻度至中度抑郁症患者的疗效。材料和方法:在一项为期8周的双盲平行组试验中,51名患者随机服用20 mg氟西汀或350 mg中草药,每天两次。汉密尔顿抑郁量表(HAM-D)用于评估0、4和8周患者的抑郁严重程度。结果:根据汉密尔顿评分,氟西汀治疗组和中药治疗组在4周和8周后无显著差异(p>0.05)。口干是唯一报告的副作用,中药组的副作用显著较低(p结论:埃莫埃姆和穿孔虫具有与氟西汀相似的抗抑郁特性,可作为氟西汀的替代品用于治疗抑郁症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
The antidepressant effect of combined extracts of Hypericum perforatum and Echium amoenum supplementation in patients with depression symptoms: A randomized clinical trial.

Objective: Echium amoenum and Hypericum perforatum dried flowers have been used for therapy of mental disorders in Iranian traditional medicine. In this study, we assessed the efficacy of the E. amoenum and H. perforatum extracts in patients with mild to moderate depression.

Materials and methods: In an 8-week double-blind, parallel-group trial, 51 patients randomly consumed 20 mg of fluoxetine or 350 mg of herbal medicine twice daily. The Hamilton Rating Scale for Depression (HAM-D) was used to assess depression severity in patients at weeks 0, 4, and 8.

Results: According to the Hamilton score, there were no significant differences between the fluoxetine- and herbal medicine-treated groups after 4 and 8 weeks (p>0.05). Dry mouth was the only reported side effect which was significantly lower in the herbal group (p<0.05) in weeks 2 and 4.

Conclusion: E. amoenum and H. perforatum have anti-depressant properties similar to fluoxetine and they can be used to treat depression as an alternative to fluoxetine.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
期刊最新文献
Aloe vera supplementation improves cardiovascular risk factors in hemodialysis patients: A randomized, double-blind, placebo-controlled trial. An in vitro antiviral evaluation of punicalagin toward influenza A virus. Apigenin attenuates serum concentrations of TNF-a, interleukin 1b and interleukin 6 in lipopolysaccharide-stimulated rats. Comparison of effects of P-coumaric acid and coumarin on colorectal cancer cell line by inducing apoptosis and autophagy. Effect of pretreatment with Devil's Claw on locomotor activity, infarct volume, and neuronal density in focal cerebral ischemia in rats.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1