ChoCO-W前瞻性观察性全球研究:COVID-19是否会增加坏疽性胆囊炎?

IF 6 1区 医学 Q1 EMERGENCY MEDICINE World Journal of Emergency Surgery Pub Date : 2022-12-16 DOI:10.1186/s13017-022-00466-4
Belinda De Simone, Fikri M Abu-Zidan, Elie Chouillard, Salomone Di Saverio, Massimo Sartelli, Mauro Podda, Carlos Augusto Gomes, Ernest E Moore, Susan J Moug, Luca Ansaloni, Yoram Kluger, Federico Coccolini, Aitor Landaluce-Olavarria, Begoña Estraviz-Mateos, Ana Uriguen-Etxeberria, Alessio Giordano, Alfonso Palmieri Luna, Luz Adriana Hernández Amín, Adriana María Palmieri Hernández, Amanda Shabana, Zakaria Andee Dzulkarnaen, Muhammad Asyraf Othman, Mohamad Ikhwan Sani, Andrea Balla, Rosa Scaramuzzo, Pasquale Lepiane, Andrea Bottari, Fabio Staderini, Fabio Cianchi, Andrea Cavallaro, Antonio Zanghì, Alessandro Cappellani, Roberto Campagnacci, Angela Maurizi, Mario Martinotti, Annamaria Ruggieri, Asri Che Jusoh, Karim Abdul Rahman, Anis Suraya M Zulkifli, Barbara Petronio, Belén Matías-García, Ana Quiroga-Valcárcel, Fernando Mendoza-Moreno, Boyko Atanasov, Fabio Cesare Campanile, Ilaria Vecchioni, Luca Cardinali, Grazia Travaglini, Elisa Sebastiani, Serge Chooklin, Serhii Chuklin, Pasquale Cianci, Enrico Restini, Sabino Capuzzolo, Giuseppe Currò, Rosalinda Filippo, Michele Rispoli, Daniel Aparicio-Sánchez, Virginia Durán Muñóz-Cruzado, Sandra Dios Barbeito, Samir Delibegovic, Amar Kesetovic, Diego Sasia, Felice Borghi, Giorgio Giraudo, Diego Visconti, Emanuele Doria, Mauro Santarelli, Davide Luppi, Stefano Bonilauri, Ugo Grossi, Giacomo Zanus, Alberto Sartori, Giacomo Piatto, Maurizio De Luca, Domenico Vita, Luigi Conti, Patrizio Capelli, Gaetano Maria Cattaneo, Athanasios Marinis, Styliani-Aikaterini Vederaki, Mehmet Bayrak, Yasemin Altıntas, Mustafa Yener Uzunoglu, Iskender Eren Demirbas, Yuksel Altinel, Serhat Meric, Yunus Emre Aktimur, Derya Salim Uymaz, Nail Omarov, Ibrahim Azamat, Eftychios Lostoridis, Eleni-Aikaterini Nagorni, Antonio Pujante, Gabriele Anania, Cristina Bombardini, Francesco Bagolini, Emre Gonullu, Baris Mantoglu, Recayi Capoglu, Stefano Cappato, Elena Muzio, Elif Colak, Suleyman Polat, Zehra Alan Koylu, Fatih Altintoprak, Zülfü Bayhan, Emrah Akin, Enrico Andolfi, Sulce Rezart, Jae Il Kim, Sung Won Jung, Yong Chan Shin, Octavian Enciu, Elena Adelina Toma, Fabio Medas, Gian Luigi Canu, Federico Cappellacci, Fabrizio D'Acapito, Giorgio Ercolani, Leonardo Solaini, Francesco Roscio, Federico Clerici, Roberta Gelmini, Francesco Serra, Elena Giulia Rossi, Francesco Fleres, Guglielmo Clarizia, Alessandro Spolini, Francesco Ferrara, Gabriela Nita, Jlenia Sarnari, Mahir Gachabayov, Abakar Abdullaev, Gaetano Poillucci, Gian Marco Palini, Simone Veneroni, Gianluca Garulli, Micaela Piccoli, Gianmaria Casoni Pattacini, Francesca Pecchini, Giulio Argenio, Mariano Fortunato Armellino, Giuseppe Brisinda, Silvia Tedesco, Pietro Fransvea, Giuseppe Ietto, Caterina Franchi, Giulio Carcano, Gennaro Martines, Giuseppe Trigiante, Giulia Negro, Gustavo Machain Vega, Agustín Rodríguez González, Leonardo Ojeda, Gaetano Piccolo, Andrea Bondurri, Anna Maffioli, Claudio Guerci, Boo Han Sin, Zamri Zuhdi, Azlanudin Azman, Hussam Mousa, Shadi Al Bahri, Goran Augustin, Ivan Romic, Trpimir Moric, Ioannis Nikolopoulos, Jacopo Andreuccetti, Giusto Pignata, Rossella D'Alessio, Jakub Kenig, Urszula Skorus, Gustavo Pereira Fraga, Elcio Shiyoiti Hirano, Jackson Vinícius de Lima Bertuol, Arda Isik, Eray Kurnaz, Mohammad Sohail Asghar, Ameer Afzal, Ali Akbar, Taxiarchis Konstantinos Nikolouzakis, Konstantinos Lasithiotakis, Emmanuel Chrysos, Koray Das, Nazmi Özer, Ahmet Seker, Mohamed Ibrahim, Hytham K S Hamid, Ahmed Babiker, Konstantinos Bouliaris, George Koukoulis, Chrysoula-Christina Kolla, Andrea Lucchi, Laura Agostinelli, Antonio Taddei, Laura Fortuna, Carlotta Agostini, Leo Licari, Simona Viola, Cosimo Callari, Letizia Laface, Emmanuele Abate, Massimiliano Casati, Alessandro Anastasi, Giuseppe Canonico, Linda Gabellini, Lorenzo Tosi, Anna Guariniello, Federico Zanzi, Lovenish Bains, Larysa Sydorchuk, Oksana Iftoda, Andrii Sydorchuk, Michele Malerba, Federico Costanzo, Raffaele Galleano, Michela Monteleone, Andrea Costanzi, Carlo Riva, Maciej Walędziak, Andrzej Kwiatkowski, Łukasz Czyżykowski, Piotr Major, Marcin Strzałka, Maciej Matyja, Michal Natkaniec, Maria Rosaria Valenti, Maria Domenica Pia Di Vita, Maria Sotiropoulou, Stylianos Kapiris, Damien Massalou, Massimiliano Veroux, Alessio Volpicelli, Rossella Gioco, Matteo Uccelli, Marta Bonaldi, Stefano Olmi, Matteo Nardi, Giada Livadoti, Cristian Mesina, Theodor Viorel Dumitrescu, Mihai Calin Ciorbagiu, Michele Ammendola, Giorgio Ammerata, Roberto Romano, Mihail Slavchev, Evangelos P Misiakos, Emmanouil Pikoulis, Dimitrios Papaconstantinou, Mohamed Elbahnasawy, Sherief Abdel-Elsalam, Daniel M Felsenreich, Julia Jedamzik, Nikolaos V Michalopoulos, Theodoros A Sidiropoulos, Maria Papadoliopoulou, Nicola Cillara, Antonello Deserra, Alessandro Cannavera, Ionuţ Negoi, Dimitrios Schizas, Athanasios Syllaios, Ilias Vagios, Stavros Gourgiotis, Nick Dai, Rekha Gurung, Marcus Norrey, Antonio Pesce, Carlo Vittorio Feo, Nicolo' Fabbri, Nikolaos Machairas, Panagiotis Dorovinis, Myrto D Keramida, Francesk Mulita, Georgios Ioannis Verras, Michail Vailas, Omer Yalkin, Nidal Iflazoglu, Direnc Yigit, Oussama Baraket, Karim Ayed, Mohamed Hedi Ghalloussi, Parmenion Patias, Georgios Ntokos, Razrim Rahim, Miklosh Bala, Asaf Kedar, Robert G Sawyer, Anna Trinh, Kelsey Miller, Ruslan Sydorchuk, Ruslan Knut, Oleksandr Plehutsa, Rumeysa Kevser Liman, Zeynep Ozkan, Saleh Abdel Kader, Sanjay Gupta, Monika Gureh, Sara Saeidi, Mohsen Aliakbarian, Amin Dalili, Tomohisa Shoko, Mitsuaki Kojima, Raira Nakamoto, Semra Demirli Atici, Gizem Kilinc Tuncer, Tayfun Kaya, Spiros G Delis, Stefano Rossi, Biagio Picardi, Simone Rossi Del Monte, Tania Triantafyllou, Dimitrios Theodorou, Tadeja Pintar, Jure Salobir, Dimitrios K Manatakis, Nikolaos Tasis, Vasileios Acheimastos, Orestis Ioannidis, Lydia Loutzidou, Savvas Symeonidis, Tiago Correia de Sá, Mónica Rocha, Tommaso Guagni, Desiré Pantalone, Gherardo Maltinti, Vladimir Khokha, Wafaa Abdel-Elsalam, Basma Ghoneim, José Antonio López-Ruiz, Yasin Kara, Syaza Zainudin, Firdaus Hayati, Nornazirah Azizan, Victoria Tan Phooi Khei, Rebecca Choy Xin Yi, Harivinthan Sellappan, Zaza Demetrashvili, Nika Lekiashvili, Ana Tvaladze, Caterina Froiio, Daniele Bernardi, Luigi Bonavina, Angeles Gil-Olarte, Sebastiano Grassia, Estela Romero-Vargas, Francesco Bianco, Andrew A Gumbs, Agron Dogjani, Ferdinando Agresta, Andrey Litvin, Zsolt J Balogh, George Gendrikson, Costanza Martino, Dimitrios Damaskos, Nikolaos Pararas, Andrew Kirkpatrick, Mikhail Kurtenkov, Felipe Couto Gomes, Adolfo Pisanu, Oreste Nardello, Fabrizio Gambarini, Hager Aref, Nicola De' Angelis, Vanni Agnoletti, Antonio Biondi, Marco Vacante, Giulia Griggio, Roberta Tutino, Marco Massani, Giovanni Bisetto, Savino Occhionorelli, Dario Andreotti, Domenico Lacavalla, Walter L Biffl, Fausto Catena
{"title":"ChoCO-W前瞻性观察性全球研究:COVID-19是否会增加坏疽性胆囊炎?","authors":"Belinda De Simone,&nbsp;Fikri M Abu-Zidan,&nbsp;Elie Chouillard,&nbsp;Salomone Di Saverio,&nbsp;Massimo Sartelli,&nbsp;Mauro Podda,&nbsp;Carlos Augusto Gomes,&nbsp;Ernest E Moore,&nbsp;Susan J Moug,&nbsp;Luca Ansaloni,&nbsp;Yoram Kluger,&nbsp;Federico Coccolini,&nbsp;Aitor Landaluce-Olavarria,&nbsp;Begoña Estraviz-Mateos,&nbsp;Ana Uriguen-Etxeberria,&nbsp;Alessio Giordano,&nbsp;Alfonso Palmieri Luna,&nbsp;Luz Adriana Hernández Amín,&nbsp;Adriana María Palmieri Hernández,&nbsp;Amanda Shabana,&nbsp;Zakaria Andee Dzulkarnaen,&nbsp;Muhammad Asyraf Othman,&nbsp;Mohamad Ikhwan Sani,&nbsp;Andrea Balla,&nbsp;Rosa Scaramuzzo,&nbsp;Pasquale Lepiane,&nbsp;Andrea Bottari,&nbsp;Fabio Staderini,&nbsp;Fabio Cianchi,&nbsp;Andrea Cavallaro,&nbsp;Antonio Zanghì,&nbsp;Alessandro Cappellani,&nbsp;Roberto Campagnacci,&nbsp;Angela Maurizi,&nbsp;Mario Martinotti,&nbsp;Annamaria Ruggieri,&nbsp;Asri Che Jusoh,&nbsp;Karim Abdul Rahman,&nbsp;Anis Suraya M Zulkifli,&nbsp;Barbara Petronio,&nbsp;Belén Matías-García,&nbsp;Ana Quiroga-Valcárcel,&nbsp;Fernando Mendoza-Moreno,&nbsp;Boyko Atanasov,&nbsp;Fabio Cesare Campanile,&nbsp;Ilaria Vecchioni,&nbsp;Luca Cardinali,&nbsp;Grazia Travaglini,&nbsp;Elisa Sebastiani,&nbsp;Serge Chooklin,&nbsp;Serhii Chuklin,&nbsp;Pasquale Cianci,&nbsp;Enrico Restini,&nbsp;Sabino Capuzzolo,&nbsp;Giuseppe Currò,&nbsp;Rosalinda Filippo,&nbsp;Michele Rispoli,&nbsp;Daniel Aparicio-Sánchez,&nbsp;Virginia Durán Muñóz-Cruzado,&nbsp;Sandra Dios Barbeito,&nbsp;Samir Delibegovic,&nbsp;Amar Kesetovic,&nbsp;Diego Sasia,&nbsp;Felice Borghi,&nbsp;Giorgio Giraudo,&nbsp;Diego Visconti,&nbsp;Emanuele Doria,&nbsp;Mauro Santarelli,&nbsp;Davide Luppi,&nbsp;Stefano Bonilauri,&nbsp;Ugo Grossi,&nbsp;Giacomo Zanus,&nbsp;Alberto Sartori,&nbsp;Giacomo Piatto,&nbsp;Maurizio De Luca,&nbsp;Domenico Vita,&nbsp;Luigi Conti,&nbsp;Patrizio Capelli,&nbsp;Gaetano Maria Cattaneo,&nbsp;Athanasios Marinis,&nbsp;Styliani-Aikaterini Vederaki,&nbsp;Mehmet Bayrak,&nbsp;Yasemin Altıntas,&nbsp;Mustafa Yener Uzunoglu,&nbsp;Iskender Eren Demirbas,&nbsp;Yuksel Altinel,&nbsp;Serhat Meric,&nbsp;Yunus Emre Aktimur,&nbsp;Derya Salim Uymaz,&nbsp;Nail Omarov,&nbsp;Ibrahim Azamat,&nbsp;Eftychios Lostoridis,&nbsp;Eleni-Aikaterini Nagorni,&nbsp;Antonio Pujante,&nbsp;Gabriele Anania,&nbsp;Cristina Bombardini,&nbsp;Francesco Bagolini,&nbsp;Emre Gonullu,&nbsp;Baris Mantoglu,&nbsp;Recayi Capoglu,&nbsp;Stefano Cappato,&nbsp;Elena Muzio,&nbsp;Elif Colak,&nbsp;Suleyman Polat,&nbsp;Zehra Alan Koylu,&nbsp;Fatih Altintoprak,&nbsp;Zülfü Bayhan,&nbsp;Emrah Akin,&nbsp;Enrico Andolfi,&nbsp;Sulce Rezart,&nbsp;Jae Il Kim,&nbsp;Sung Won Jung,&nbsp;Yong Chan Shin,&nbsp;Octavian Enciu,&nbsp;Elena Adelina Toma,&nbsp;Fabio Medas,&nbsp;Gian Luigi Canu,&nbsp;Federico Cappellacci,&nbsp;Fabrizio D'Acapito,&nbsp;Giorgio Ercolani,&nbsp;Leonardo Solaini,&nbsp;Francesco Roscio,&nbsp;Federico Clerici,&nbsp;Roberta Gelmini,&nbsp;Francesco Serra,&nbsp;Elena Giulia Rossi,&nbsp;Francesco Fleres,&nbsp;Guglielmo Clarizia,&nbsp;Alessandro Spolini,&nbsp;Francesco Ferrara,&nbsp;Gabriela Nita,&nbsp;Jlenia Sarnari,&nbsp;Mahir Gachabayov,&nbsp;Abakar Abdullaev,&nbsp;Gaetano Poillucci,&nbsp;Gian Marco Palini,&nbsp;Simone Veneroni,&nbsp;Gianluca Garulli,&nbsp;Micaela Piccoli,&nbsp;Gianmaria Casoni Pattacini,&nbsp;Francesca Pecchini,&nbsp;Giulio Argenio,&nbsp;Mariano Fortunato Armellino,&nbsp;Giuseppe Brisinda,&nbsp;Silvia Tedesco,&nbsp;Pietro Fransvea,&nbsp;Giuseppe Ietto,&nbsp;Caterina Franchi,&nbsp;Giulio Carcano,&nbsp;Gennaro Martines,&nbsp;Giuseppe Trigiante,&nbsp;Giulia Negro,&nbsp;Gustavo Machain Vega,&nbsp;Agustín Rodríguez González,&nbsp;Leonardo Ojeda,&nbsp;Gaetano Piccolo,&nbsp;Andrea Bondurri,&nbsp;Anna Maffioli,&nbsp;Claudio Guerci,&nbsp;Boo Han Sin,&nbsp;Zamri Zuhdi,&nbsp;Azlanudin Azman,&nbsp;Hussam Mousa,&nbsp;Shadi Al Bahri,&nbsp;Goran Augustin,&nbsp;Ivan Romic,&nbsp;Trpimir Moric,&nbsp;Ioannis Nikolopoulos,&nbsp;Jacopo Andreuccetti,&nbsp;Giusto Pignata,&nbsp;Rossella D'Alessio,&nbsp;Jakub Kenig,&nbsp;Urszula Skorus,&nbsp;Gustavo Pereira Fraga,&nbsp;Elcio Shiyoiti Hirano,&nbsp;Jackson Vinícius de Lima Bertuol,&nbsp;Arda Isik,&nbsp;Eray Kurnaz,&nbsp;Mohammad Sohail Asghar,&nbsp;Ameer Afzal,&nbsp;Ali Akbar,&nbsp;Taxiarchis Konstantinos Nikolouzakis,&nbsp;Konstantinos Lasithiotakis,&nbsp;Emmanuel Chrysos,&nbsp;Koray Das,&nbsp;Nazmi Özer,&nbsp;Ahmet Seker,&nbsp;Mohamed Ibrahim,&nbsp;Hytham K S Hamid,&nbsp;Ahmed Babiker,&nbsp;Konstantinos Bouliaris,&nbsp;George Koukoulis,&nbsp;Chrysoula-Christina Kolla,&nbsp;Andrea Lucchi,&nbsp;Laura Agostinelli,&nbsp;Antonio Taddei,&nbsp;Laura Fortuna,&nbsp;Carlotta Agostini,&nbsp;Leo Licari,&nbsp;Simona Viola,&nbsp;Cosimo Callari,&nbsp;Letizia Laface,&nbsp;Emmanuele Abate,&nbsp;Massimiliano Casati,&nbsp;Alessandro Anastasi,&nbsp;Giuseppe Canonico,&nbsp;Linda Gabellini,&nbsp;Lorenzo Tosi,&nbsp;Anna Guariniello,&nbsp;Federico Zanzi,&nbsp;Lovenish Bains,&nbsp;Larysa Sydorchuk,&nbsp;Oksana Iftoda,&nbsp;Andrii Sydorchuk,&nbsp;Michele Malerba,&nbsp;Federico Costanzo,&nbsp;Raffaele Galleano,&nbsp;Michela Monteleone,&nbsp;Andrea Costanzi,&nbsp;Carlo Riva,&nbsp;Maciej Walędziak,&nbsp;Andrzej Kwiatkowski,&nbsp;Łukasz Czyżykowski,&nbsp;Piotr Major,&nbsp;Marcin Strzałka,&nbsp;Maciej Matyja,&nbsp;Michal Natkaniec,&nbsp;Maria Rosaria Valenti,&nbsp;Maria Domenica Pia Di Vita,&nbsp;Maria Sotiropoulou,&nbsp;Stylianos Kapiris,&nbsp;Damien Massalou,&nbsp;Massimiliano Veroux,&nbsp;Alessio Volpicelli,&nbsp;Rossella Gioco,&nbsp;Matteo Uccelli,&nbsp;Marta Bonaldi,&nbsp;Stefano Olmi,&nbsp;Matteo Nardi,&nbsp;Giada Livadoti,&nbsp;Cristian Mesina,&nbsp;Theodor Viorel Dumitrescu,&nbsp;Mihai Calin Ciorbagiu,&nbsp;Michele Ammendola,&nbsp;Giorgio Ammerata,&nbsp;Roberto Romano,&nbsp;Mihail Slavchev,&nbsp;Evangelos P Misiakos,&nbsp;Emmanouil Pikoulis,&nbsp;Dimitrios Papaconstantinou,&nbsp;Mohamed Elbahnasawy,&nbsp;Sherief Abdel-Elsalam,&nbsp;Daniel M Felsenreich,&nbsp;Julia Jedamzik,&nbsp;Nikolaos V Michalopoulos,&nbsp;Theodoros A Sidiropoulos,&nbsp;Maria Papadoliopoulou,&nbsp;Nicola Cillara,&nbsp;Antonello Deserra,&nbsp;Alessandro Cannavera,&nbsp;Ionuţ Negoi,&nbsp;Dimitrios Schizas,&nbsp;Athanasios Syllaios,&nbsp;Ilias Vagios,&nbsp;Stavros Gourgiotis,&nbsp;Nick Dai,&nbsp;Rekha Gurung,&nbsp;Marcus Norrey,&nbsp;Antonio Pesce,&nbsp;Carlo Vittorio Feo,&nbsp;Nicolo' Fabbri,&nbsp;Nikolaos Machairas,&nbsp;Panagiotis Dorovinis,&nbsp;Myrto D Keramida,&nbsp;Francesk Mulita,&nbsp;Georgios Ioannis Verras,&nbsp;Michail Vailas,&nbsp;Omer Yalkin,&nbsp;Nidal Iflazoglu,&nbsp;Direnc Yigit,&nbsp;Oussama Baraket,&nbsp;Karim Ayed,&nbsp;Mohamed Hedi Ghalloussi,&nbsp;Parmenion Patias,&nbsp;Georgios Ntokos,&nbsp;Razrim Rahim,&nbsp;Miklosh Bala,&nbsp;Asaf Kedar,&nbsp;Robert G Sawyer,&nbsp;Anna Trinh,&nbsp;Kelsey Miller,&nbsp;Ruslan Sydorchuk,&nbsp;Ruslan Knut,&nbsp;Oleksandr Plehutsa,&nbsp;Rumeysa Kevser Liman,&nbsp;Zeynep Ozkan,&nbsp;Saleh Abdel Kader,&nbsp;Sanjay Gupta,&nbsp;Monika Gureh,&nbsp;Sara Saeidi,&nbsp;Mohsen Aliakbarian,&nbsp;Amin Dalili,&nbsp;Tomohisa Shoko,&nbsp;Mitsuaki Kojima,&nbsp;Raira Nakamoto,&nbsp;Semra Demirli Atici,&nbsp;Gizem Kilinc Tuncer,&nbsp;Tayfun Kaya,&nbsp;Spiros G Delis,&nbsp;Stefano Rossi,&nbsp;Biagio Picardi,&nbsp;Simone Rossi Del Monte,&nbsp;Tania Triantafyllou,&nbsp;Dimitrios Theodorou,&nbsp;Tadeja Pintar,&nbsp;Jure Salobir,&nbsp;Dimitrios K Manatakis,&nbsp;Nikolaos Tasis,&nbsp;Vasileios Acheimastos,&nbsp;Orestis Ioannidis,&nbsp;Lydia Loutzidou,&nbsp;Savvas Symeonidis,&nbsp;Tiago Correia de Sá,&nbsp;Mónica Rocha,&nbsp;Tommaso Guagni,&nbsp;Desiré Pantalone,&nbsp;Gherardo Maltinti,&nbsp;Vladimir Khokha,&nbsp;Wafaa Abdel-Elsalam,&nbsp;Basma Ghoneim,&nbsp;José Antonio López-Ruiz,&nbsp;Yasin Kara,&nbsp;Syaza Zainudin,&nbsp;Firdaus Hayati,&nbsp;Nornazirah Azizan,&nbsp;Victoria Tan Phooi Khei,&nbsp;Rebecca Choy Xin Yi,&nbsp;Harivinthan Sellappan,&nbsp;Zaza Demetrashvili,&nbsp;Nika Lekiashvili,&nbsp;Ana Tvaladze,&nbsp;Caterina Froiio,&nbsp;Daniele Bernardi,&nbsp;Luigi Bonavina,&nbsp;Angeles Gil-Olarte,&nbsp;Sebastiano Grassia,&nbsp;Estela Romero-Vargas,&nbsp;Francesco Bianco,&nbsp;Andrew A Gumbs,&nbsp;Agron Dogjani,&nbsp;Ferdinando Agresta,&nbsp;Andrey Litvin,&nbsp;Zsolt J Balogh,&nbsp;George Gendrikson,&nbsp;Costanza Martino,&nbsp;Dimitrios Damaskos,&nbsp;Nikolaos Pararas,&nbsp;Andrew Kirkpatrick,&nbsp;Mikhail Kurtenkov,&nbsp;Felipe Couto Gomes,&nbsp;Adolfo Pisanu,&nbsp;Oreste Nardello,&nbsp;Fabrizio Gambarini,&nbsp;Hager Aref,&nbsp;Nicola De' Angelis,&nbsp;Vanni Agnoletti,&nbsp;Antonio Biondi,&nbsp;Marco Vacante,&nbsp;Giulia Griggio,&nbsp;Roberta Tutino,&nbsp;Marco Massani,&nbsp;Giovanni Bisetto,&nbsp;Savino Occhionorelli,&nbsp;Dario Andreotti,&nbsp;Domenico Lacavalla,&nbsp;Walter L Biffl,&nbsp;Fausto Catena","doi":"10.1186/s13017-022-00466-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not.</p><p><strong>Methods: </strong>Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not.</p><p><strong>Results: </strong>A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001].</p><p><strong>Conclusions: </strong>The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands.</p>","PeriodicalId":48867,"journal":{"name":"World Journal of Emergency Surgery","volume":null,"pages":null},"PeriodicalIF":6.0000,"publicationDate":"2022-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755784/pdf/","citationCount":"3","resultStr":"{\"title\":\"The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?\",\"authors\":\"Belinda De Simone,&nbsp;Fikri M Abu-Zidan,&nbsp;Elie Chouillard,&nbsp;Salomone Di Saverio,&nbsp;Massimo Sartelli,&nbsp;Mauro Podda,&nbsp;Carlos Augusto Gomes,&nbsp;Ernest E Moore,&nbsp;Susan J Moug,&nbsp;Luca Ansaloni,&nbsp;Yoram Kluger,&nbsp;Federico Coccolini,&nbsp;Aitor Landaluce-Olavarria,&nbsp;Begoña Estraviz-Mateos,&nbsp;Ana Uriguen-Etxeberria,&nbsp;Alessio Giordano,&nbsp;Alfonso Palmieri Luna,&nbsp;Luz Adriana Hernández Amín,&nbsp;Adriana María Palmieri Hernández,&nbsp;Amanda Shabana,&nbsp;Zakaria Andee Dzulkarnaen,&nbsp;Muhammad Asyraf Othman,&nbsp;Mohamad Ikhwan Sani,&nbsp;Andrea Balla,&nbsp;Rosa Scaramuzzo,&nbsp;Pasquale Lepiane,&nbsp;Andrea Bottari,&nbsp;Fabio Staderini,&nbsp;Fabio Cianchi,&nbsp;Andrea Cavallaro,&nbsp;Antonio Zanghì,&nbsp;Alessandro Cappellani,&nbsp;Roberto Campagnacci,&nbsp;Angela Maurizi,&nbsp;Mario Martinotti,&nbsp;Annamaria Ruggieri,&nbsp;Asri Che Jusoh,&nbsp;Karim Abdul Rahman,&nbsp;Anis Suraya M Zulkifli,&nbsp;Barbara Petronio,&nbsp;Belén Matías-García,&nbsp;Ana Quiroga-Valcárcel,&nbsp;Fernando Mendoza-Moreno,&nbsp;Boyko Atanasov,&nbsp;Fabio Cesare Campanile,&nbsp;Ilaria Vecchioni,&nbsp;Luca Cardinali,&nbsp;Grazia Travaglini,&nbsp;Elisa Sebastiani,&nbsp;Serge Chooklin,&nbsp;Serhii Chuklin,&nbsp;Pasquale Cianci,&nbsp;Enrico Restini,&nbsp;Sabino Capuzzolo,&nbsp;Giuseppe Currò,&nbsp;Rosalinda Filippo,&nbsp;Michele Rispoli,&nbsp;Daniel Aparicio-Sánchez,&nbsp;Virginia Durán Muñóz-Cruzado,&nbsp;Sandra Dios Barbeito,&nbsp;Samir Delibegovic,&nbsp;Amar Kesetovic,&nbsp;Diego Sasia,&nbsp;Felice Borghi,&nbsp;Giorgio Giraudo,&nbsp;Diego Visconti,&nbsp;Emanuele Doria,&nbsp;Mauro Santarelli,&nbsp;Davide Luppi,&nbsp;Stefano Bonilauri,&nbsp;Ugo Grossi,&nbsp;Giacomo Zanus,&nbsp;Alberto Sartori,&nbsp;Giacomo Piatto,&nbsp;Maurizio De Luca,&nbsp;Domenico Vita,&nbsp;Luigi Conti,&nbsp;Patrizio Capelli,&nbsp;Gaetano Maria Cattaneo,&nbsp;Athanasios Marinis,&nbsp;Styliani-Aikaterini Vederaki,&nbsp;Mehmet Bayrak,&nbsp;Yasemin Altıntas,&nbsp;Mustafa Yener Uzunoglu,&nbsp;Iskender Eren Demirbas,&nbsp;Yuksel Altinel,&nbsp;Serhat Meric,&nbsp;Yunus Emre Aktimur,&nbsp;Derya Salim Uymaz,&nbsp;Nail Omarov,&nbsp;Ibrahim Azamat,&nbsp;Eftychios Lostoridis,&nbsp;Eleni-Aikaterini Nagorni,&nbsp;Antonio Pujante,&nbsp;Gabriele Anania,&nbsp;Cristina Bombardini,&nbsp;Francesco Bagolini,&nbsp;Emre Gonullu,&nbsp;Baris Mantoglu,&nbsp;Recayi Capoglu,&nbsp;Stefano Cappato,&nbsp;Elena Muzio,&nbsp;Elif Colak,&nbsp;Suleyman Polat,&nbsp;Zehra Alan Koylu,&nbsp;Fatih Altintoprak,&nbsp;Zülfü Bayhan,&nbsp;Emrah Akin,&nbsp;Enrico Andolfi,&nbsp;Sulce Rezart,&nbsp;Jae Il Kim,&nbsp;Sung Won Jung,&nbsp;Yong Chan Shin,&nbsp;Octavian Enciu,&nbsp;Elena Adelina Toma,&nbsp;Fabio Medas,&nbsp;Gian Luigi Canu,&nbsp;Federico Cappellacci,&nbsp;Fabrizio D'Acapito,&nbsp;Giorgio Ercolani,&nbsp;Leonardo Solaini,&nbsp;Francesco Roscio,&nbsp;Federico Clerici,&nbsp;Roberta Gelmini,&nbsp;Francesco Serra,&nbsp;Elena Giulia Rossi,&nbsp;Francesco Fleres,&nbsp;Guglielmo Clarizia,&nbsp;Alessandro Spolini,&nbsp;Francesco Ferrara,&nbsp;Gabriela Nita,&nbsp;Jlenia Sarnari,&nbsp;Mahir Gachabayov,&nbsp;Abakar Abdullaev,&nbsp;Gaetano Poillucci,&nbsp;Gian Marco Palini,&nbsp;Simone Veneroni,&nbsp;Gianluca Garulli,&nbsp;Micaela Piccoli,&nbsp;Gianmaria Casoni Pattacini,&nbsp;Francesca Pecchini,&nbsp;Giulio Argenio,&nbsp;Mariano Fortunato Armellino,&nbsp;Giuseppe Brisinda,&nbsp;Silvia Tedesco,&nbsp;Pietro Fransvea,&nbsp;Giuseppe Ietto,&nbsp;Caterina Franchi,&nbsp;Giulio Carcano,&nbsp;Gennaro Martines,&nbsp;Giuseppe Trigiante,&nbsp;Giulia Negro,&nbsp;Gustavo Machain Vega,&nbsp;Agustín Rodríguez González,&nbsp;Leonardo Ojeda,&nbsp;Gaetano Piccolo,&nbsp;Andrea Bondurri,&nbsp;Anna Maffioli,&nbsp;Claudio Guerci,&nbsp;Boo Han Sin,&nbsp;Zamri Zuhdi,&nbsp;Azlanudin Azman,&nbsp;Hussam Mousa,&nbsp;Shadi Al Bahri,&nbsp;Goran Augustin,&nbsp;Ivan Romic,&nbsp;Trpimir Moric,&nbsp;Ioannis Nikolopoulos,&nbsp;Jacopo Andreuccetti,&nbsp;Giusto Pignata,&nbsp;Rossella D'Alessio,&nbsp;Jakub Kenig,&nbsp;Urszula Skorus,&nbsp;Gustavo Pereira Fraga,&nbsp;Elcio Shiyoiti Hirano,&nbsp;Jackson Vinícius de Lima Bertuol,&nbsp;Arda Isik,&nbsp;Eray Kurnaz,&nbsp;Mohammad Sohail Asghar,&nbsp;Ameer Afzal,&nbsp;Ali Akbar,&nbsp;Taxiarchis Konstantinos Nikolouzakis,&nbsp;Konstantinos Lasithiotakis,&nbsp;Emmanuel Chrysos,&nbsp;Koray Das,&nbsp;Nazmi Özer,&nbsp;Ahmet Seker,&nbsp;Mohamed Ibrahim,&nbsp;Hytham K S Hamid,&nbsp;Ahmed Babiker,&nbsp;Konstantinos Bouliaris,&nbsp;George Koukoulis,&nbsp;Chrysoula-Christina Kolla,&nbsp;Andrea Lucchi,&nbsp;Laura Agostinelli,&nbsp;Antonio Taddei,&nbsp;Laura Fortuna,&nbsp;Carlotta Agostini,&nbsp;Leo Licari,&nbsp;Simona Viola,&nbsp;Cosimo Callari,&nbsp;Letizia Laface,&nbsp;Emmanuele Abate,&nbsp;Massimiliano Casati,&nbsp;Alessandro Anastasi,&nbsp;Giuseppe Canonico,&nbsp;Linda Gabellini,&nbsp;Lorenzo Tosi,&nbsp;Anna Guariniello,&nbsp;Federico Zanzi,&nbsp;Lovenish Bains,&nbsp;Larysa Sydorchuk,&nbsp;Oksana Iftoda,&nbsp;Andrii Sydorchuk,&nbsp;Michele Malerba,&nbsp;Federico Costanzo,&nbsp;Raffaele Galleano,&nbsp;Michela Monteleone,&nbsp;Andrea Costanzi,&nbsp;Carlo Riva,&nbsp;Maciej Walędziak,&nbsp;Andrzej Kwiatkowski,&nbsp;Łukasz Czyżykowski,&nbsp;Piotr Major,&nbsp;Marcin Strzałka,&nbsp;Maciej Matyja,&nbsp;Michal Natkaniec,&nbsp;Maria Rosaria Valenti,&nbsp;Maria Domenica Pia Di Vita,&nbsp;Maria Sotiropoulou,&nbsp;Stylianos Kapiris,&nbsp;Damien Massalou,&nbsp;Massimiliano Veroux,&nbsp;Alessio Volpicelli,&nbsp;Rossella Gioco,&nbsp;Matteo Uccelli,&nbsp;Marta Bonaldi,&nbsp;Stefano Olmi,&nbsp;Matteo Nardi,&nbsp;Giada Livadoti,&nbsp;Cristian Mesina,&nbsp;Theodor Viorel Dumitrescu,&nbsp;Mihai Calin Ciorbagiu,&nbsp;Michele Ammendola,&nbsp;Giorgio Ammerata,&nbsp;Roberto Romano,&nbsp;Mihail Slavchev,&nbsp;Evangelos P Misiakos,&nbsp;Emmanouil Pikoulis,&nbsp;Dimitrios Papaconstantinou,&nbsp;Mohamed Elbahnasawy,&nbsp;Sherief Abdel-Elsalam,&nbsp;Daniel M Felsenreich,&nbsp;Julia Jedamzik,&nbsp;Nikolaos V Michalopoulos,&nbsp;Theodoros A Sidiropoulos,&nbsp;Maria Papadoliopoulou,&nbsp;Nicola Cillara,&nbsp;Antonello Deserra,&nbsp;Alessandro Cannavera,&nbsp;Ionuţ Negoi,&nbsp;Dimitrios Schizas,&nbsp;Athanasios Syllaios,&nbsp;Ilias Vagios,&nbsp;Stavros Gourgiotis,&nbsp;Nick Dai,&nbsp;Rekha Gurung,&nbsp;Marcus Norrey,&nbsp;Antonio Pesce,&nbsp;Carlo Vittorio Feo,&nbsp;Nicolo' Fabbri,&nbsp;Nikolaos Machairas,&nbsp;Panagiotis Dorovinis,&nbsp;Myrto D Keramida,&nbsp;Francesk Mulita,&nbsp;Georgios Ioannis Verras,&nbsp;Michail Vailas,&nbsp;Omer Yalkin,&nbsp;Nidal Iflazoglu,&nbsp;Direnc Yigit,&nbsp;Oussama Baraket,&nbsp;Karim Ayed,&nbsp;Mohamed Hedi Ghalloussi,&nbsp;Parmenion Patias,&nbsp;Georgios Ntokos,&nbsp;Razrim Rahim,&nbsp;Miklosh Bala,&nbsp;Asaf Kedar,&nbsp;Robert G Sawyer,&nbsp;Anna Trinh,&nbsp;Kelsey Miller,&nbsp;Ruslan Sydorchuk,&nbsp;Ruslan Knut,&nbsp;Oleksandr Plehutsa,&nbsp;Rumeysa Kevser Liman,&nbsp;Zeynep Ozkan,&nbsp;Saleh Abdel Kader,&nbsp;Sanjay Gupta,&nbsp;Monika Gureh,&nbsp;Sara Saeidi,&nbsp;Mohsen Aliakbarian,&nbsp;Amin Dalili,&nbsp;Tomohisa Shoko,&nbsp;Mitsuaki Kojima,&nbsp;Raira Nakamoto,&nbsp;Semra Demirli Atici,&nbsp;Gizem Kilinc Tuncer,&nbsp;Tayfun Kaya,&nbsp;Spiros G Delis,&nbsp;Stefano Rossi,&nbsp;Biagio Picardi,&nbsp;Simone Rossi Del Monte,&nbsp;Tania Triantafyllou,&nbsp;Dimitrios Theodorou,&nbsp;Tadeja Pintar,&nbsp;Jure Salobir,&nbsp;Dimitrios K Manatakis,&nbsp;Nikolaos Tasis,&nbsp;Vasileios Acheimastos,&nbsp;Orestis Ioannidis,&nbsp;Lydia Loutzidou,&nbsp;Savvas Symeonidis,&nbsp;Tiago Correia de Sá,&nbsp;Mónica Rocha,&nbsp;Tommaso Guagni,&nbsp;Desiré Pantalone,&nbsp;Gherardo Maltinti,&nbsp;Vladimir Khokha,&nbsp;Wafaa Abdel-Elsalam,&nbsp;Basma Ghoneim,&nbsp;José Antonio López-Ruiz,&nbsp;Yasin Kara,&nbsp;Syaza Zainudin,&nbsp;Firdaus Hayati,&nbsp;Nornazirah Azizan,&nbsp;Victoria Tan Phooi Khei,&nbsp;Rebecca Choy Xin Yi,&nbsp;Harivinthan Sellappan,&nbsp;Zaza Demetrashvili,&nbsp;Nika Lekiashvili,&nbsp;Ana Tvaladze,&nbsp;Caterina Froiio,&nbsp;Daniele Bernardi,&nbsp;Luigi Bonavina,&nbsp;Angeles Gil-Olarte,&nbsp;Sebastiano Grassia,&nbsp;Estela Romero-Vargas,&nbsp;Francesco Bianco,&nbsp;Andrew A Gumbs,&nbsp;Agron Dogjani,&nbsp;Ferdinando Agresta,&nbsp;Andrey Litvin,&nbsp;Zsolt J Balogh,&nbsp;George Gendrikson,&nbsp;Costanza Martino,&nbsp;Dimitrios Damaskos,&nbsp;Nikolaos Pararas,&nbsp;Andrew Kirkpatrick,&nbsp;Mikhail Kurtenkov,&nbsp;Felipe Couto Gomes,&nbsp;Adolfo Pisanu,&nbsp;Oreste Nardello,&nbsp;Fabrizio Gambarini,&nbsp;Hager Aref,&nbsp;Nicola De' Angelis,&nbsp;Vanni Agnoletti,&nbsp;Antonio Biondi,&nbsp;Marco Vacante,&nbsp;Giulia Griggio,&nbsp;Roberta Tutino,&nbsp;Marco Massani,&nbsp;Giovanni Bisetto,&nbsp;Savino Occhionorelli,&nbsp;Dario Andreotti,&nbsp;Domenico Lacavalla,&nbsp;Walter L Biffl,&nbsp;Fausto Catena\",\"doi\":\"10.1186/s13017-022-00466-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not.</p><p><strong>Methods: </strong>Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not.</p><p><strong>Results: </strong>A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001].</p><p><strong>Conclusions: </strong>The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands.</p>\",\"PeriodicalId\":48867,\"journal\":{\"name\":\"World Journal of Emergency Surgery\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.0000,\"publicationDate\":\"2022-12-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755784/pdf/\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World Journal of Emergency Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s13017-022-00466-4\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"EMERGENCY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Emergency Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13017-022-00466-4","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"EMERGENCY MEDICINE","Score":null,"Total":0}
引用次数: 3

摘要

背景:据报道，在COVID-19大流行期间，高发病率和潜在致命性坏疽性胆囊炎的发病率有所增加。ChoCO-W研究的目的是比较COVID-19疾病患者与非COVID-19疾病患者急性胆囊炎的临床表现和结局。方法:前瞻性收集数据6个月(2020年10月1日至2021年4月30日)，随访1个月。2020年10月，SARS CoV-2的Delta变体首次被分离出来。根据STROBE指南对人口学和临床数据进行分析和报告。将感染COVID-19的患者与未感染COVID-19的患者的基线特征和临床结果进行比较。结果:共有2893名患者，来自42个国家，218个中心，纳入本研究，中位年龄为61.3岁(SD: 17.39)岁;男性1481例(51%)。新冠肺炎阳性180例(6.9%)，阴性2412例(93.1%)。结论:急诊就诊的急性胆囊炎患者中，新冠肺炎患者坏疽性胆囊炎的发生率高于非新冠肺炎患者。COVID患者的坏疽性胆囊炎与高级别Clavien-Dindo术后并发症、更长的住院时间和更高的死亡率相关。新冠肺炎患者开腹胆囊切除术率高于非新冠肺炎患者。建议尽可能推迟新冠肺炎患者的手术治疗，以降低发病率和死亡率。COVID-19感染和坏疽性胆囊炎不是腹腔镜胆囊切除术的绝对禁忌症，由专家逐个评估。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

摘要图片

摘要图片

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?

Background: The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not.

Methods: Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not.

Results: A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001].

Conclusions: The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands.

求助全文
通过发布文献求助，成功后即可免费获取论文全文。 去求助
来源期刊
World Journal of Emergency Surgery
World Journal of Emergency Surgery EMERGENCY MEDICINE-SURGERY
CiteScore
14.50
自引率
5.00%
发文量
60
审稿时长
10 weeks
期刊介绍： The World Journal of Emergency Surgery is an open access, peer-reviewed journal covering all facets of clinical and basic research in traumatic and non-traumatic emergency surgery and related fields. Topics include emergency surgery, acute care surgery, trauma surgery, intensive care, trauma management, and resuscitation, among others.
期刊最新文献
Effectiveness and safety of low molecular weight heparin in the management of acute pancreatitis: a systematic review and meta-analysis Exploring aortic morphology and determining variable-distance insertion lengths for fluoroscopy-free resuscitative endovascular balloon occlusion of the aorta (REBOA) Emergency robotic surgery: the experience of a single center and review of the literature Outcomes and prognosis of postpartum hemorrhage according to management protocol: an 11-year retrospective study from two referral centers. Strategies to prevent blood loss and reduce transfusion in emergency general surgery, WSES-AAST consensus paper.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们：info@booksci.cn
Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1