首页 > 最新文献

World Journal of Emergency Surgery最新文献

英文 中文
Erector spinae plane block (ESPB) enhances hemodynamic stability decreasing analgesic requirements in surgical stabilization of rib fractures (SSRFs) 脊柱后凸平面阻滞(ESPB)可增强血流动力学稳定性,减少肋骨骨折(SSRF)手术稳定过程中的镇痛需求
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-11-20 DOI: 10.1186/s13017-024-00567-2
Chien-An Liao, Yi-Jun Chen, Shih-Jyun Shen, Qi-An Wang, Szu-An Chen, Chien-Hung Liao, Jr-Rung Lin, Chao-Wei Lee, Hsin-I Tsai
To evaluate the efficacy of erector spinae plane block (ESPB) on intraoperative hemodynamic stability, opioid and inhalation anesthetic requirements and postoperative analgesic effects in patients undergoing surgical stabilization of rib fractures (SSRFs). We retrospectively reviewed 173 patients who underwent surgical stabilization of rib fractures between May 2020 and December 2023. The patients were allocated into the ESPB group or the control group. Demographic data, intraoperative hemodynamic parameters, total intraoperative opioid consumption, the average minimum alveolar concentration (MAC) of inhalational anesthetics, postoperative simple analgesics and opioid consumption and the length of hospital stay were included in the analysis. Compared with the control group, the ESPB group had a lower heart rate (HR) in the first 90 min after surgical incision and lower systolic blood pressure (SBP) and mean arterial pressure (MAP) at the beginning of surgery. Intraoperatively, a notable reduction in fentanyl consumption was observed in the ESPB group (p = 0.004), whereas no significant difference was observed in the average MAC of inhalational agents (p = 0.073). Postoperatively, the ESPB group required fewer doses of simple analgesics in the first 24 h (p < 0.001) and 48 h (p = 0.029). No statistically significant difference in the length of hospital stay (p = 0.608) was observed between the groups. ESPB was shown to enhance intraoperative hemodynamic stability, reduce opioid consumption and decrease postoperative analgesic consumption in patients who underwent SSRF. These results suggest that ESPB may serve as a valuable component of multimodal analgesia protocols for SSRF. Larger prospective studies are warranted to confirm the results and evaluate long-term outcomes.
目的:评估竖脊肌平面阻滞(ESPB)对接受手术稳定肋骨骨折(SSRFs)患者术中血流动力学稳定性、阿片类药物和吸入麻醉剂需求以及术后镇痛效果的影响。我们对 2020 年 5 月至 2023 年 12 月期间接受肋骨骨折手术稳定治疗的 173 例患者进行了回顾性研究。这些患者被分配到ESPB组或对照组。分析包括人口统计学数据、术中血流动力学参数、术中阿片类药物的总消耗量、吸入麻醉剂的平均最小肺泡浓度(MAC)、术后简单镇痛剂和阿片类药物的消耗量以及住院时间。与对照组相比,ESPB 组在手术切口后 90 分钟内心率(HR)较低,手术开始时收缩压(SBP)和平均动脉压(MAP)较低。术中观察到,ESPB 组的芬太尼用量明显减少(p = 0.004),而吸入剂的平均 MAC 没有明显差异(p = 0.073)。术后,ESPB 组在最初 24 小时(p < 0.001)和 48 小时(p = 0.029)内所需的简单镇痛剂剂量较少。两组的住院时间(p = 0.608)无统计学差异。研究表明,ESPB 可增强接受 SSRF 患者术中血流动力学的稳定性、减少阿片类药物的用量并降低术后镇痛药的用量。这些结果表明,ESPB 可作为 SSRF 多模式镇痛方案的重要组成部分。我们有必要进行更大规模的前瞻性研究,以确认结果并评估长期疗效。
{"title":"Erector spinae plane block (ESPB) enhances hemodynamic stability decreasing analgesic requirements in surgical stabilization of rib fractures (SSRFs)","authors":"Chien-An Liao, Yi-Jun Chen, Shih-Jyun Shen, Qi-An Wang, Szu-An Chen, Chien-Hung Liao, Jr-Rung Lin, Chao-Wei Lee, Hsin-I Tsai","doi":"10.1186/s13017-024-00567-2","DOIUrl":"https://doi.org/10.1186/s13017-024-00567-2","url":null,"abstract":"To evaluate the efficacy of erector spinae plane block (ESPB) on intraoperative hemodynamic stability, opioid and inhalation anesthetic requirements and postoperative analgesic effects in patients undergoing surgical stabilization of rib fractures (SSRFs). We retrospectively reviewed 173 patients who underwent surgical stabilization of rib fractures between May 2020 and December 2023. The patients were allocated into the ESPB group or the control group. Demographic data, intraoperative hemodynamic parameters, total intraoperative opioid consumption, the average minimum alveolar concentration (MAC) of inhalational anesthetics, postoperative simple analgesics and opioid consumption and the length of hospital stay were included in the analysis. Compared with the control group, the ESPB group had a lower heart rate (HR) in the first 90 min after surgical incision and lower systolic blood pressure (SBP) and mean arterial pressure (MAP) at the beginning of surgery. Intraoperatively, a notable reduction in fentanyl consumption was observed in the ESPB group (p = 0.004), whereas no significant difference was observed in the average MAC of inhalational agents (p = 0.073). Postoperatively, the ESPB group required fewer doses of simple analgesics in the first 24 h (p < 0.001) and 48 h (p = 0.029). No statistically significant difference in the length of hospital stay (p = 0.608) was observed between the groups. ESPB was shown to enhance intraoperative hemodynamic stability, reduce opioid consumption and decrease postoperative analgesic consumption in patients who underwent SSRF. These results suggest that ESPB may serve as a valuable component of multimodal analgesia protocols for SSRF. Larger prospective studies are warranted to confirm the results and evaluate long-term outcomes.","PeriodicalId":48867,"journal":{"name":"World Journal of Emergency Surgery","volume":"57 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new technology for medical and surgical data organisation: the WSES-WJES Decentralised Knowledge Graph 医疗和手术数据组织新技术:WSES-WJES 分散知识图谱
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-11-20 DOI: 10.1186/s13017-024-00563-6
Andrey A. Litvin, Sophiya B. Rumovskaya, Belinda De Simone, Lucienne Kasongo, Massimo Sartelli, Federico Coccolini, Luca Ansaloni, Ernest E. Moore, Walter Biffl, Fausto Catena
The quality of Big Data analysis in medicine and surgery heavily depends on the methods used for clinical data collection, organization, and storage. The Knowledge Graph (KG) represents knowledge through a semantic model, enhancing connections between diverse and complex information. While it can improve the quality of health data collection, it has limitations that can be addressed by the Decentralized (blockchain-powered) Knowledge Graph (DKG). We report our experience in developing a DKG to organize data and knowledge in the field of emergency surgery. The authors leveraged the cyb.ai protocol, a decentralized protocol within the Cosmos network, to develop the Emergency Surgery DKG. They populated the DKG with relevant information using publications from the World Society of Emergency Surgery (WSES) featured in the World Journal of Emergency Surgery (WJES). The result was the Decentralized Knowledge Graph (DKG) for the WSES-WJES bibliography. Utilizing a DKG enables more effective structuring and organization of medical knowledge. This facilitates a deeper understanding of the interrelationships between various aspects of medicine and surgery, ultimately enhancing the diagnosis and treatment of different diseases. The system’s design aims to be inclusive and user-friendly, providing access to high-quality surgical knowledge for healthcare providers worldwide, regardless of their technological capabilities or geographical location. As the DKG evolves, ongoing attention to user feedback, regulatory frameworks, and ethical considerations will be critical to its long-term success and global impact in the surgical field.
医学和外科大数据分析的质量在很大程度上取决于临床数据的收集、组织和存储方法。知识图谱(KG)通过语义模型表示知识,加强了各种复杂信息之间的联系。虽然它可以提高健康数据收集的质量,但它也有局限性,而去中心化(区块链驱动)知识图谱(DKG)可以解决这些问题。我们报告了开发 DKG 以组织急诊外科领域数据和知识的经验。作者利用 Cosmos 网络中的去中心化协议 cyb.ai 协议开发了急诊外科 DKG。他们利用《世界急诊外科杂志》(WJES)上刊登的世界急诊外科协会(WSES)的出版物,将相关信息填充到 DKG 中。这就是 WSES-WJES 书目的分散知识图谱 (DKG)。利用 DKG 可以更有效地构建和组织医学知识。这有助于加深对医学和外科各方面相互关系的理解,最终提高对不同疾病的诊断和治疗水平。该系统的设计旨在实现包容性和用户友好性,为世界各地的医疗服务提供者提供获取高质量外科知识的途径,无论其技术能力或地理位置如何。随着 DKG 的发展,对用户反馈、监管框架和伦理因素的持续关注对其在外科领域的长期成功和全球影响至关重要。
{"title":"A new technology for medical and surgical data organisation: the WSES-WJES Decentralised Knowledge Graph","authors":"Andrey A. Litvin, Sophiya B. Rumovskaya, Belinda De Simone, Lucienne Kasongo, Massimo Sartelli, Federico Coccolini, Luca Ansaloni, Ernest E. Moore, Walter Biffl, Fausto Catena","doi":"10.1186/s13017-024-00563-6","DOIUrl":"https://doi.org/10.1186/s13017-024-00563-6","url":null,"abstract":"The quality of Big Data analysis in medicine and surgery heavily depends on the methods used for clinical data collection, organization, and storage. The Knowledge Graph (KG) represents knowledge through a semantic model, enhancing connections between diverse and complex information. While it can improve the quality of health data collection, it has limitations that can be addressed by the Decentralized (blockchain-powered) Knowledge Graph (DKG). We report our experience in developing a DKG to organize data and knowledge in the field of emergency surgery. The authors leveraged the cyb.ai protocol, a decentralized protocol within the Cosmos network, to develop the Emergency Surgery DKG. They populated the DKG with relevant information using publications from the World Society of Emergency Surgery (WSES) featured in the World Journal of Emergency Surgery (WJES). The result was the Decentralized Knowledge Graph (DKG) for the WSES-WJES bibliography. Utilizing a DKG enables more effective structuring and organization of medical knowledge. This facilitates a deeper understanding of the interrelationships between various aspects of medicine and surgery, ultimately enhancing the diagnosis and treatment of different diseases. The system’s design aims to be inclusive and user-friendly, providing access to high-quality surgical knowledge for healthcare providers worldwide, regardless of their technological capabilities or geographical location. As the DKG evolves, ongoing attention to user feedback, regulatory frameworks, and ethical considerations will be critical to its long-term success and global impact in the surgical field.","PeriodicalId":48867,"journal":{"name":"World Journal of Emergency Surgery","volume":"18 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultra minimally invasive surgical stabilization of Rib fractures (uMI-SSRF): reduction and fixation techniques to minimize the surgical wound 超微创手术稳定肋骨骨折(uMI-SSRF):减少手术伤口的还原和固定技术
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-11-15 DOI: 10.1186/s13017-024-00566-3
Hon Lok Lo, Jui-Ying Lee, Chun Kuan Lu, On-Yee Lo, Cheng-Chang Lu, Dong-Lin Tsai, Sung-Yen Lin
Rib fractures are common in trauma patients, often leading to complications such as pneumonia and prolonged hospitalization. Surgical Stabilization of Rib Fractures (SSRF) has become increasingly prevalent in treating severe cases. However, traditional approaches, like posterolateral thoracotomy, are invasive and cause significant muscle damage. Recently, muscle-sparing minimally invasive techniques have been introduced, yet they still require advanced reduction and fixation techniques to avoid complications. This study presents an “ultra” minimally invasive SSRF (uMI-SSRF) technique designed to minimize surgical wounds and soft tissue damage while maintaining the benefits of rib fixation. This study involved 76 patients with multiple rib fractures treated using the uMI-SSRF technique between August 2021 and December 2023. Preoperative chest tomography with 3D reconstruction was used for surgical planning. The technique employed small incisions (3–5 cm), muscle-sparing approaches, and advanced fixation techniques. Data on patient demographics, intraoperative details, and postoperative outcomes were collected. The mean patient age was 58 years, with 66% being male. On average, patients had 6.4 fractured ribs, and 3.5 ribs with 3.88 plates were fixed per surgery, achieving a fixation/fracture ratio of 59%. The average wound length was 4.2 cm, with a mean operation time of 122 min. Most patients required only one incision (74%). The median hospital length of stay was 7 days, with a pneumonia rate of 5%. No wound infections or implant-related complications were observed. The uMI-SSRF technique effectively reduces wound size and soft tissue damage in rib fracture stabilization while maintaining high fixation quality. This method shows promise for improving patient outcomes, reducing recovery time, and minimizing complications. Further studies with larger sample sizes and comparisons with other methods are warranted to verify the advantages of uMI-SSRF.
肋骨骨折是外伤患者的常见病,通常会导致肺炎和长期住院等并发症。肋骨骨折外科稳定术(SSRF)在治疗严重病例中越来越普遍。然而,后外侧胸廓切开术等传统方法具有创伤性,会对肌肉造成严重损伤。最近,出现了保护肌肉的微创技术,但仍需要先进的还原和固定技术来避免并发症。本研究介绍了一种 "超 "微创 SSRF(uMI-SSRF)技术,旨在最大限度地减少手术伤口和软组织损伤,同时保持肋骨固定的优势。这项研究涉及 2021 年 8 月至 2023 年 12 月期间使用 uMI-SSRF 技术治疗的 76 例多发性肋骨骨折患者。术前胸部断层扫描与三维重建用于手术规划。该技术采用了小切口(3-5 厘米)、肌肉保全方法和先进的固定技术。收集了患者的人口统计学、术中细节和术后效果等数据。患者平均年龄为 58 岁,66% 为男性。患者平均有 6.4 根肋骨骨折,每次手术固定了 3.5 根肋骨和 3.88 块钢板,固定/骨折比率为 59%。伤口平均长度为 4.2 厘米,平均手术时间为 122 分钟。大多数患者只需要一个切口(74%)。住院时间中位数为 7 天,肺炎发生率为 5%。未发现伤口感染或与植入物相关的并发症。uMI-SSRF 技术能有效减少肋骨骨折稳定过程中的伤口面积和软组织损伤,同时保持较高的固定质量。这种方法有望改善患者预后、缩短恢复时间并最大限度地减少并发症。为了验证 uMI-SSRF 的优势,有必要进行样本量更大的进一步研究,并与其他方法进行比较。
{"title":"Ultra minimally invasive surgical stabilization of Rib fractures (uMI-SSRF): reduction and fixation techniques to minimize the surgical wound","authors":"Hon Lok Lo, Jui-Ying Lee, Chun Kuan Lu, On-Yee Lo, Cheng-Chang Lu, Dong-Lin Tsai, Sung-Yen Lin","doi":"10.1186/s13017-024-00566-3","DOIUrl":"https://doi.org/10.1186/s13017-024-00566-3","url":null,"abstract":"Rib fractures are common in trauma patients, often leading to complications such as pneumonia and prolonged hospitalization. Surgical Stabilization of Rib Fractures (SSRF) has become increasingly prevalent in treating severe cases. However, traditional approaches, like posterolateral thoracotomy, are invasive and cause significant muscle damage. Recently, muscle-sparing minimally invasive techniques have been introduced, yet they still require advanced reduction and fixation techniques to avoid complications. This study presents an “ultra” minimally invasive SSRF (uMI-SSRF) technique designed to minimize surgical wounds and soft tissue damage while maintaining the benefits of rib fixation. This study involved 76 patients with multiple rib fractures treated using the uMI-SSRF technique between August 2021 and December 2023. Preoperative chest tomography with 3D reconstruction was used for surgical planning. The technique employed small incisions (3–5 cm), muscle-sparing approaches, and advanced fixation techniques. Data on patient demographics, intraoperative details, and postoperative outcomes were collected. The mean patient age was 58 years, with 66% being male. On average, patients had 6.4 fractured ribs, and 3.5 ribs with 3.88 plates were fixed per surgery, achieving a fixation/fracture ratio of 59%. The average wound length was 4.2 cm, with a mean operation time of 122 min. Most patients required only one incision (74%). The median hospital length of stay was 7 days, with a pneumonia rate of 5%. No wound infections or implant-related complications were observed. The uMI-SSRF technique effectively reduces wound size and soft tissue damage in rib fracture stabilization while maintaining high fixation quality. This method shows promise for improving patient outcomes, reducing recovery time, and minimizing complications. Further studies with larger sample sizes and comparisons with other methods are warranted to verify the advantages of uMI-SSRF.","PeriodicalId":48867,"journal":{"name":"World Journal of Emergency Surgery","volume":"25 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasonic dissection versus electrocautery dissection in laparoscopic cholecystectomy for acute cholecystitis: a randomized controlled trial (SONOCHOL-trial) 腹腔镜胆囊切除术治疗急性胆囊炎时超声波剥离与电烧剥离:随机对照试验(SONOCHOL-试验)
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-11-13 DOI: 10.1186/s13017-024-00565-4
My Blohm, Gabriel Sandblom, Lars Enochsson, Yücel Cengiz, Haytham Bayadsi, Joakim Hennings, Angelica Diaz Pannes, Erik Stenberg, Kerstin Bewö, Johanna Österberg
Laparoscopic cholecystectomy with ultrasonic dissection presents a compelling alternative to conventional electrocautery. The evidence for elective cholecystectomy supports the adoption of ultrasonic dissection, citing advantages such as reduced operating time, diminished bleeding, shorter hospital stays and decreased postoperative pain and nausea. However, the efficacy of this procedure in emergency surgery and patients diagnosed with acute cholecystitis remains uncertain. The aim of this study was to compare outcomes of electrocautery and ultrasonic dissection in patients with acute cholecystitis. A randomized, parallel, double-blinded, multicentre controlled trial was conducted across eight Swedish hospitals. Eligible participants were individuals aged ≥ 18 years with acute cholecystitis lasting ≤ 7 days. Laparoscopic cholecystectomy was performed in the emergency setting as soon as local circumstances permitted. Random allocation to electrocautery or ultrasonic dissection was performed in a 1:1 ratio. The primary endpoint was the total complication rate, analysed using an intention-to-treat approach. The primary outcome was analysed using logistic generalized estimated equations. Patients, postoperative caregivers, and follow-up personnel were blinded to group assignment. From September 2019 to March 2023, 300 patients were enrolled and randomly assigned to electrocautery dissection (n = 148) and ultrasonic dissection (n = 152). No significant difference in complication rate was observed between the groups (risk difference [RD] 1.6%, 95% confidence interval [CI], − 7.2% to 10.4%, P = 0.720). No significant disparities in operating time, conversion rate, hospital stay or readmission rates between the groups were noted. Haemostatic agents were more frequently used in electrocautery dissection (RD 10.6%, 95% CI, 1.3% to 19.8%, P = 0.025). Ultrasonic dissection and electrocautery dissection demonstrate comparable risks for complications in emergency surgery for patients with acute cholecystitis. Ultrasonic dissection is a viable alternative to electrocautery dissection or can be used as a complementary method in laparoscopic cholecystectomy for acute cholecystitis. The trial was registered prior to conducting the research on http://clinical.trials.gov , NCT03014817.
超声波剥离腹腔镜胆囊切除术是传统电烧术的一个令人信服的替代方案。有证据表明,选择性胆囊切除术具有缩短手术时间、减少出血、缩短住院时间、减轻术后疼痛和恶心等优点,因此支持采用超声波剥离术。然而,该手术在急诊手术和急性胆囊炎患者中的疗效仍不确定。本研究旨在比较急性胆囊炎患者接受电灼术和超声波剥离术的疗效。瑞典的八家医院开展了一项随机、平行、双盲、多中心对照试验。符合条件的参与者为年龄≥ 18 岁、急性胆囊炎持续时间≤ 7 天的患者。在当地条件允许的情况下,尽快在急诊室进行腹腔镜胆囊切除术。以1:1的比例随机分配电灼术或超声波剥离术。主要终点是总并发症发生率,采用意向治疗法进行分析。主要结果采用逻辑广义估计方程进行分析。患者、术后护理人员和随访人员对组别分配保密。从2019年9月到2023年3月,300名患者入组并随机分配到电烧剥离(n = 148)和超声波剥离(n = 152)。两组患者的并发症发生率无明显差异(风险差异 [RD] 1.6%,95% 置信区间 [CI],- 7.2% 至 10.4%,P = 0.720)。两组在手术时间、转换率、住院时间或再入院率方面无明显差异。止血剂更常用于电烧剥离(RD 10.6%,95% CI,1.3% 至 19.8%,P = 0.025)。在急性胆囊炎患者的急诊手术中,超声波剥离和电烧剥离的并发症风险相当。在急性胆囊炎的腹腔镜胆囊切除术中,超声波剥离是电烧剥离的可行替代方法,也可作为一种补充方法。该试验在进行研究之前已在 http://clinical.trials.gov , NCT03014817 上注册。
{"title":"Ultrasonic dissection versus electrocautery dissection in laparoscopic cholecystectomy for acute cholecystitis: a randomized controlled trial (SONOCHOL-trial)","authors":"My Blohm, Gabriel Sandblom, Lars Enochsson, Yücel Cengiz, Haytham Bayadsi, Joakim Hennings, Angelica Diaz Pannes, Erik Stenberg, Kerstin Bewö, Johanna Österberg","doi":"10.1186/s13017-024-00565-4","DOIUrl":"https://doi.org/10.1186/s13017-024-00565-4","url":null,"abstract":"Laparoscopic cholecystectomy with ultrasonic dissection presents a compelling alternative to conventional electrocautery. The evidence for elective cholecystectomy supports the adoption of ultrasonic dissection, citing advantages such as reduced operating time, diminished bleeding, shorter hospital stays and decreased postoperative pain and nausea. However, the efficacy of this procedure in emergency surgery and patients diagnosed with acute cholecystitis remains uncertain. The aim of this study was to compare outcomes of electrocautery and ultrasonic dissection in patients with acute cholecystitis. A randomized, parallel, double-blinded, multicentre controlled trial was conducted across eight Swedish hospitals. Eligible participants were individuals aged ≥ 18 years with acute cholecystitis lasting ≤ 7 days. Laparoscopic cholecystectomy was performed in the emergency setting as soon as local circumstances permitted. Random allocation to electrocautery or ultrasonic dissection was performed in a 1:1 ratio. The primary endpoint was the total complication rate, analysed using an intention-to-treat approach. The primary outcome was analysed using logistic generalized estimated equations. Patients, postoperative caregivers, and follow-up personnel were blinded to group assignment. From September 2019 to March 2023, 300 patients were enrolled and randomly assigned to electrocautery dissection (n = 148) and ultrasonic dissection (n = 152). No significant difference in complication rate was observed between the groups (risk difference [RD] 1.6%, 95% confidence interval [CI], − 7.2% to 10.4%, P = 0.720). No significant disparities in operating time, conversion rate, hospital stay or readmission rates between the groups were noted. Haemostatic agents were more frequently used in electrocautery dissection (RD 10.6%, 95% CI, 1.3% to 19.8%, P = 0.025). Ultrasonic dissection and electrocautery dissection demonstrate comparable risks for complications in emergency surgery for patients with acute cholecystitis. Ultrasonic dissection is a viable alternative to electrocautery dissection or can be used as a complementary method in laparoscopic cholecystectomy for acute cholecystitis. The trial was registered prior to conducting the research on http://clinical.trials.gov , NCT03014817.","PeriodicalId":48867,"journal":{"name":"World Journal of Emergency Surgery","volume":"3 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical stabilization of rib fractures (SSRF): the WSES and CWIS position paper 肋骨骨折手术稳定(SSRF):WSES 和 CWIS 立场文件
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-10-18 DOI: 10.1186/s13017-024-00559-2
Giacomo Sermonesi, Riccardo Bertelli, Fredric M. Pieracci, Zsolt J. Balogh, Raul Coimbra, Joseph M. Galante, Andreas Hecker, Dieter Weber, Zachary M. Bauman, Susan Kartiko, Bhavik Patel, SarahAnn S. Whitbeck, Thomas W. White, Kevin N. Harrell, Daniele Perrina, Alessia Rampini, Brian Tian, Francesco Amico, Solomon G. Beka, Luigi Bonavina, Marco Ceresoli, Lorenzo Cobianchi, Federico Coccolini, Yunfeng Cui, Francesca Dal Mas, Belinda De Simone, Isidoro Di Carlo, Salomone Di Saverio, Agron Dogjani, Andreas Fette, Gustavo P. Fraga, Carlos Augusto Gomes, Jim S. Khan, Andrew W. Kirkpatrick, Vitor F. Kruger, Ari Leppäniemi, Andrey Litvin, Andrea Mingoli, David Costa Navarro, Eliseo Passera, Michele Pisano, Mauro Podda, Emanuele Russo, Boris Sakakushev, Domenico Santonastaso, Massimo Sartelli, Vishal G. Shelat, Edward Tan, Imtiaz Wani, Fikri M. Abu-Zidan, Walter L. Biffl, Ian Civil, Rifat Latifi, Ingo Marzi, Edoardo Picetti, Manos Pikoulis, Vanni Agnoletti, Francesca Bravi, Carlo Vall..
Rib fractures are one of the most common traumatic injuries and may result in significant morbidity and mortality. Despite growing evidence, technological advances and increasing acceptance, surgical stabilization of rib fractures (SSRF) remains not uniformly considered in trauma centers. Indications, contraindications, appropriate timing, surgical approaches and utilized implants are part of an ongoing debate. The present position paper, which is endorsed by the World Society of Emergency Surgery (WSES), and supported by the Chest Wall Injury Society, aims to provide a review of the literature investigating the use of SSRF in rib fracture management to develop graded position statements, providing an updated guide and reference for SSRF. This position paper was developed according to the WSES methodology. A steering committee performed the literature review and drafted the position paper. An international panel of experts then critically revised the manuscript and discussed it in detail, to develop a consensus on the position statements. A total of 287 studies (systematic reviews, randomized clinical trial, prospective and retrospective comparative studies, case series, original articles) have been selected from an initial pool of 9928 studies. Thirty-nine graded position statements were put forward to address eight crucial aspects of SSRF: surgical indications, contraindications, optimal timing of surgery, preoperative imaging evaluation, rib fracture sites for surgical fixation, management of concurrent thoracic injuries, surgical approach, stabilization methods and material selection. This consensus document addresses the key focus questions on surgical treatment of rib fractures. The expert recommendations clarify current evidences on SSRF indications, timing, operative planning, approaches and techniques, with the aim to guide clinicians in optimizing the management of rib fractures, to improve patient outcomes and direct future research.
肋骨骨折是最常见的外伤之一,可能导致严重的发病率和死亡率。尽管证据越来越多、技术越来越先进、接受度越来越高,但创伤中心仍未统一考虑对肋骨骨折进行手术稳定(SSRF)。适应症、禁忌症、适当时机、手术方法和使用的植入物等问题一直存在争议。本立场文件得到了世界急诊外科学会(WSES)的认可和胸壁损伤学会的支持,旨在对研究在肋骨骨折治疗中使用 SSRF 的文献进行回顾,以制定分级立场声明,为 SSRF 提供最新指南和参考。本立场文件是根据 WSES 方法制定的。指导委员会进行了文献综述并起草了立场文件。随后,一个国际专家小组对稿件进行了严格修订和详细讨论,就立场声明达成了共识。从最初的 9928 项研究中,共筛选出 287 项研究(系统综述、随机临床试验、前瞻性和回顾性比较研究、病例系列、原创文章)。针对 SSRF 的八个关键方面提出了 39 份分级立场声明:手术适应症、禁忌症、最佳手术时机、术前影像学评估、手术固定的肋骨骨折部位、并发胸廓损伤的处理、手术方法、稳定方法和材料选择。本共识文件探讨了肋骨骨折手术治疗的关键重点问题。专家建议阐明了 SSRF 适应症、时机、手术计划、方法和技术方面的现有证据,旨在指导临床医生优化肋骨骨折的治疗,改善患者预后并指导未来研究。
{"title":"Surgical stabilization of rib fractures (SSRF): the WSES and CWIS position paper","authors":"Giacomo Sermonesi, Riccardo Bertelli, Fredric M. Pieracci, Zsolt J. Balogh, Raul Coimbra, Joseph M. Galante, Andreas Hecker, Dieter Weber, Zachary M. Bauman, Susan Kartiko, Bhavik Patel, SarahAnn S. Whitbeck, Thomas W. White, Kevin N. Harrell, Daniele Perrina, Alessia Rampini, Brian Tian, Francesco Amico, Solomon G. Beka, Luigi Bonavina, Marco Ceresoli, Lorenzo Cobianchi, Federico Coccolini, Yunfeng Cui, Francesca Dal Mas, Belinda De Simone, Isidoro Di Carlo, Salomone Di Saverio, Agron Dogjani, Andreas Fette, Gustavo P. Fraga, Carlos Augusto Gomes, Jim S. Khan, Andrew W. Kirkpatrick, Vitor F. Kruger, Ari Leppäniemi, Andrey Litvin, Andrea Mingoli, David Costa Navarro, Eliseo Passera, Michele Pisano, Mauro Podda, Emanuele Russo, Boris Sakakushev, Domenico Santonastaso, Massimo Sartelli, Vishal G. Shelat, Edward Tan, Imtiaz Wani, Fikri M. Abu-Zidan, Walter L. Biffl, Ian Civil, Rifat Latifi, Ingo Marzi, Edoardo Picetti, Manos Pikoulis, Vanni Agnoletti, Francesca Bravi, Carlo Vall..","doi":"10.1186/s13017-024-00559-2","DOIUrl":"https://doi.org/10.1186/s13017-024-00559-2","url":null,"abstract":"Rib fractures are one of the most common traumatic injuries and may result in significant morbidity and mortality. Despite growing evidence, technological advances and increasing acceptance, surgical stabilization of rib fractures (SSRF) remains not uniformly considered in trauma centers. Indications, contraindications, appropriate timing, surgical approaches and utilized implants are part of an ongoing debate. The present position paper, which is endorsed by the World Society of Emergency Surgery (WSES), and supported by the Chest Wall Injury Society, aims to provide a review of the literature investigating the use of SSRF in rib fracture management to develop graded position statements, providing an updated guide and reference for SSRF. This position paper was developed according to the WSES methodology. A steering committee performed the literature review and drafted the position paper. An international panel of experts then critically revised the manuscript and discussed it in detail, to develop a consensus on the position statements. A total of 287 studies (systematic reviews, randomized clinical trial, prospective and retrospective comparative studies, case series, original articles) have been selected from an initial pool of 9928 studies. Thirty-nine graded position statements were put forward to address eight crucial aspects of SSRF: surgical indications, contraindications, optimal timing of surgery, preoperative imaging evaluation, rib fracture sites for surgical fixation, management of concurrent thoracic injuries, surgical approach, stabilization methods and material selection. This consensus document addresses the key focus questions on surgical treatment of rib fractures. The expert recommendations clarify current evidences on SSRF indications, timing, operative planning, approaches and techniques, with the aim to guide clinicians in optimizing the management of rib fractures, to improve patient outcomes and direct future research.","PeriodicalId":48867,"journal":{"name":"World Journal of Emergency Surgery","volume":"65 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
International Delphi consensus on the management of percutaneous choleystostomy in acute cholecystitis (E-AHPBA, ANS, WSES societies) 关于急性胆囊炎经皮胆囊造口术管理的国际德尔菲共识(E-AHPBA、ANS、WSES 协会)
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-10-12 DOI: 10.1186/s13017-024-00561-8
José M. Ramia, Mario Serradilla-Martín, Celia Villodre, Juan J. Rubio, Fernando Rotellar, Ajith K. Siriwardena, Go Wakabayashi, Fausto Catena
There has been a progressive increase in the use of percutaneous cholecystostomy (PC) in acute cholecystitis (AC) over the last decades due to population aging, and the support of guidelines (Tokyo Guidelines (TG), World Society of Emergency Surgery (WSES) Guidelines) as a valid therapeutical option. However, there are many unanswered questions about the management of PCs. An international consensus on indications and PC management using Delphi methodology with contributions from experts from three surgical societies (EAHPBA, ANS, WSES) have been performed. A two-round Delphi consensus, which included 27 questions, was sent to key opinion leaders in AC. Participants were asked to indicate their ‘agreement/disagreement’ using a 5-point Likert scale. Survey items with less than 70% consensus were excluded from the second round. For inclusion in the final recommendations, each survey item had to have reached a group consensus (≥ 70% agreement) by the end of the two survey rounds. 54 completed both rounds (82% of invitees). Six questions got > 70% and are included in consensus recommendations: In patients with acute cholecystitis, when there is a clear indication of PC, it is not necessary to wait 48 h to be carried out; Surgery is the first therapeutic option for the TG grade II acute cholecystitis in a patient suitable for surgery; Before PC removal a cholangiography should be done; There is no indication for PC in Tokyo Guidelines (TG) grade I patients; Transhepatic approach is the route of choice for PC; and after PC, laparoscopic cholecystectomy is the preferred approach (93.1%). Only six statements about PC management after AC got an international consensus. An international guideline about the management of PCs are necessary.
过去几十年来,由于人口老龄化以及相关指南(《东京指南》(TG)、《世界急诊外科学会指南》(WSES))的支持,经皮胆囊造口术(PC)作为一种有效的治疗方法在急性胆囊炎(AC)中的应用逐渐增多。然而,关于 PC 的管理仍有许多未解之谜。三个外科协会(EAHPBA、ANS 和 WSES)的专家采用德尔菲方法就 PC 的适应症和管理达成了国际共识。包括 27 个问题在内的两轮德尔菲共识已发送给 AC 的主要意见领袖。要求参与者使用 5 点李克特量表来表示 "同意/不同意"。共识度低于 70% 的调查项目被排除在第二轮调查之外。每个调查项目必须在两轮调查结束时达成小组共识(≥ 70% 的一致意见),才能纳入最终建议。54 人完成了两轮调查(占受邀者的 82%)。有六个问题的同意率大于 70%,并被纳入共识建议中:对于急性胆囊炎患者,如果有明确的 PC 指征,无需等待 48 小时即可实施手术;对于适合手术的 TG II 级急性胆囊炎患者,手术是首选治疗方案;PC 切除前应进行胆管造影;东京指南 (TG) I 级患者没有 PC 指征;经肝途径是 PC 的首选途径;PC 后,腹腔镜胆囊切除术是首选方法(93.1%)。只有六项关于 AC 后 PC 处理的声明获得了国际共识。有必要就 PC 的管理制定国际指南。
{"title":"International Delphi consensus on the management of percutaneous choleystostomy in acute cholecystitis (E-AHPBA, ANS, WSES societies)","authors":"José M. Ramia, Mario Serradilla-Martín, Celia Villodre, Juan J. Rubio, Fernando Rotellar, Ajith K. Siriwardena, Go Wakabayashi, Fausto Catena","doi":"10.1186/s13017-024-00561-8","DOIUrl":"https://doi.org/10.1186/s13017-024-00561-8","url":null,"abstract":"There has been a progressive increase in the use of percutaneous cholecystostomy (PC) in acute cholecystitis (AC) over the last decades due to population aging, and the support of guidelines (Tokyo Guidelines (TG), World Society of Emergency Surgery (WSES) Guidelines) as a valid therapeutical option. However, there are many unanswered questions about the management of PCs. An international consensus on indications and PC management using Delphi methodology with contributions from experts from three surgical societies (EAHPBA, ANS, WSES) have been performed. A two-round Delphi consensus, which included 27 questions, was sent to key opinion leaders in AC. Participants were asked to indicate their ‘agreement/disagreement’ using a 5-point Likert scale. Survey items with less than 70% consensus were excluded from the second round. For inclusion in the final recommendations, each survey item had to have reached a group consensus (≥ 70% agreement) by the end of the two survey rounds. 54 completed both rounds (82% of invitees). Six questions got > 70% and are included in consensus recommendations: In patients with acute cholecystitis, when there is a clear indication of PC, it is not necessary to wait 48 h to be carried out; Surgery is the first therapeutic option for the TG grade II acute cholecystitis in a patient suitable for surgery; Before PC removal a cholangiography should be done; There is no indication for PC in Tokyo Guidelines (TG) grade I patients; Transhepatic approach is the route of choice for PC; and after PC, laparoscopic cholecystectomy is the preferred approach (93.1%). Only six statements about PC management after AC got an international consensus. An international guideline about the management of PCs are necessary.","PeriodicalId":48867,"journal":{"name":"World Journal of Emergency Surgery","volume":"9 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142415491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Life-threatening event in laparoscopic hepatic surgery: Training curriculum on sudden hepatic artery haemorrhage 腹腔镜肝脏手术中危及生命的事件:突发性肝动脉出血培训课程
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-10-07 DOI: 10.1186/s13017-024-00562-7
Jin Yang, Jiasheng Cao, Yaoting Xue, Yaping Zhang, Bin Zhang, Jiahao Hu, Yuxuan Shen, Chengcheng Wu, Xiaochen Zhang, Liang Shi, Hua Liu, Bin Zheng, Jiliang Shen
Exposure of the hepatic artery is a fundamental step in many surgeries, during which iatrogenic hepatic artery injury may occur. Although the incidence of hepatic artery haemorrhage is low, its occurrence can lead to life-threatening haemorrhage. It is difficult and dangerous to accumulate clinical experience in laparoscopic hepatic artery repair in actual patients, and simulation training models for laparoscopic hepatic artery repair are currently lacking. In this study, a 3D printed model was designed to simulate the training curriculum for sudden hepatic artery haemorrhage, but whether training with the 3D printed model could yield superior skill improvement for surgeons remained to be determined. A new 3D printed model was designed for this study. Surgeons from the General Surgery Department of Sir Run Run Shaw Hospital participated in this simulation training. The surgical performance of each model was compared, and the authenticity of the model was evaluated and mechanically tested. Experienced surgeons performed better on the 3D printed model. After repeated training, inexperienced surgeons showed significant improvement of their laparoscopic hepatic artery repair skills. The authenticity of the model was generally satisfactory, but shortcomings persisted in the mechanical testing of artery wall tearing, necessitating further improvement. Few studies have investigated laparoscopic simulation training for sudden hepatic artery haemorrhage. This simulation model distinguishes surgeons with different levels of experience and allows those with less experience to improve their laparoscopic hepatic artery repair skills through training on the model.
暴露肝动脉是许多手术的基本步骤,在此过程中可能会发生肝动脉先天性损伤。虽然肝动脉大出血的发生率很低,但其发生可能导致危及生命的大出血。在实际患者身上积累腹腔镜肝动脉修补术的临床经验既困难又危险,目前还缺乏腹腔镜肝动脉修补术的模拟训练模型。本研究设计了一种3D打印模型来模拟肝动脉突发大出血的培训课程,但使用3D打印模型进行培训是否能使外科医生的技能得到更好的提高仍有待确定。本研究设计了一种新的 3D 打印模型。邵逸夫医院普通外科的外科医生参加了此次模拟训练。对每个模型的手术表现进行了比较,并对模型的真实性进行了评估和机械测试。经验丰富的外科医生在 3D 打印模型上的表现更好。经过反复训练后,经验不足的外科医生的腹腔镜肝动脉修补术技能有了显著提高。模型的真实性总体上令人满意,但在动脉壁撕裂的机械测试中仍存在不足,需要进一步改进。很少有研究对腹腔镜肝动脉突然出血的模拟训练进行调查。该模拟模型可区分不同经验水平的外科医生,让经验较少的外科医生通过模型训练提高腹腔镜肝动脉修复技能。
{"title":"Life-threatening event in laparoscopic hepatic surgery: Training curriculum on sudden hepatic artery haemorrhage","authors":"Jin Yang, Jiasheng Cao, Yaoting Xue, Yaping Zhang, Bin Zhang, Jiahao Hu, Yuxuan Shen, Chengcheng Wu, Xiaochen Zhang, Liang Shi, Hua Liu, Bin Zheng, Jiliang Shen","doi":"10.1186/s13017-024-00562-7","DOIUrl":"https://doi.org/10.1186/s13017-024-00562-7","url":null,"abstract":"Exposure of the hepatic artery is a fundamental step in many surgeries, during which iatrogenic hepatic artery injury may occur. Although the incidence of hepatic artery haemorrhage is low, its occurrence can lead to life-threatening haemorrhage. It is difficult and dangerous to accumulate clinical experience in laparoscopic hepatic artery repair in actual patients, and simulation training models for laparoscopic hepatic artery repair are currently lacking. In this study, a 3D printed model was designed to simulate the training curriculum for sudden hepatic artery haemorrhage, but whether training with the 3D printed model could yield superior skill improvement for surgeons remained to be determined. A new 3D printed model was designed for this study. Surgeons from the General Surgery Department of Sir Run Run Shaw Hospital participated in this simulation training. The surgical performance of each model was compared, and the authenticity of the model was evaluated and mechanically tested. Experienced surgeons performed better on the 3D printed model. After repeated training, inexperienced surgeons showed significant improvement of their laparoscopic hepatic artery repair skills. The authenticity of the model was generally satisfactory, but shortcomings persisted in the mechanical testing of artery wall tearing, necessitating further improvement. Few studies have investigated laparoscopic simulation training for sudden hepatic artery haemorrhage. This simulation model distinguishes surgeons with different levels of experience and allows those with less experience to improve their laparoscopic hepatic artery repair skills through training on the model.","PeriodicalId":48867,"journal":{"name":"World Journal of Emergency Surgery","volume":"55 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness and safety of low molecular weight heparin in the management of acute pancreatitis: a systematic review and meta-analysis 低分子量肝素治疗急性胰腺炎的有效性和安全性:系统回顾和荟萃分析
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-09-10 DOI: 10.1186/s13017-024-00558-3
Mauro Podda, Valentina Murzi, Paola Marongiu, Marcello Di Martino, Belinda De Simone, Kumar Jayant, Monica Ortenzi, Federico Coccolini, Massimo Sartelli, Fausto Catena, Benedetto Ielpo, Adolfo Pisanu
Recent studies suggest that low-molecular-weight heparin (LMWH) may play a role in mitigating the severity of acute pancreatitis (AP). This systematic review and meta-analysis aims to synthesise existing evidence on the effectiveness and safety of LMWH in the treatment of moderately-severe and severe AP. This systematic review and meta-analysis was conducted in accordance with the 2020 update of the PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. The systematic search was conducted in MEDLINE, the Cochrane Central Register of Controlled Trials, Scopus, and EMBASE, covering studies published up to February 2024. Randomised controlled trials (RCTs) and observational studies (n-RCTs) that reported the differences in the outcomes of AP for patients receiving LMWH in addition to the standard treatment (Intervention), compared to patients managed by standard treatment without LMWH (Control) were eligible. A random-effects model was used to calculate the pooled relative risk (RR) and mean differences (MD) with the corresponding 95% CI. Thirteen studies were included in the meta-analysis, all published between 2004 and 2022. Eight studies were RCTs, and five were n-RCTs. Data from 13,709 patients (6.971 Interventions and 6.738 Controls) were analysed. The comparison of Intervention and Control groups showed the superiority of LMWH to standard treatments in terms of overall mortality (RR = 0.44, 95% CI = 0.31; 0.64, P < 0.0001, I2 = 51%), acute necrotic collections (RR = 0.24, 95% CI = 0.09; 0.62, P = 0.003, I2 = 0%), and organ failure (RR = 0.67, 95% CI = 0.48; 0.93, P = 0.02, I2 = 78%). The Intervention group showed superior outcomes compared with the Control group for gastrointestinal bleeding (RR = 0.64, 95% CI = 0.44; 0.94, P = 0.02, I2 = 0%), length of hospital stay (MD= − 6.08, 95% CI = − 10.08; − 2.07, P = 0.003, I2 = 98%), need for operative interventions (RR = 0.50, 95% CI = 0.29; 0.87, P = 0.01, I2 = 61%), and vascular thrombosis (RR = 0.43, 95% CI = 0.31; 0.61, P < 0.00001, I2 = 0%). Moderate to high-quality evidence suggests that early intervention with LMWH could improve the prognosis of non-mild AP in terms of mortality, organ failure, and decreased incidence of vascular thrombosis. In light of our findings, integrating LMWH into the treatment regimen for moderate-severe to severe AP is advocated.
最近的研究表明,低分子量肝素(LMWH)可减轻急性胰腺炎(AP)的严重程度。本系统综述和荟萃分析旨在综合现有证据,说明 LMWH 治疗中度和重度急性胰腺炎的有效性和安全性。本系统综述和荟萃分析是根据《PRISMA 指南》2020 年更新版和《干预措施系统综述 Cochrane 手册》进行的。系统性检索在 MEDLINE、Cochrane 对照试验中央注册中心、Scopus 和 EMBASE 中进行,涵盖截至 2024 年 2 月发表的研究。符合条件的研究包括随机对照试验(RCT)和观察性研究(n-RCT),这些研究报告了在标准治疗(干预)的基础上接受 LMWH 治疗的患者与接受标准治疗但不接受 LMWH 治疗的患者(对照)在 AP 治疗结果上的差异。采用随机效应模型计算汇总相对风险 (RR) 和平均差异 (MD) 以及相应的 95% CI。荟萃分析共纳入了 13 项研究,这些研究均发表于 2004 年至 2022 年之间。其中八项为 RCT 研究,五项为 n-RCT 研究。分析了 13709 名患者(6971 名干预组和 6738 名对照组)的数据。干预组和对照组的比较显示,在总死亡率(RR = 0.44,95% CI = 0.31; 0.64,P < 0.0001,I2 = 51%)、急性坏死集结(RR = 0.24,95% CI = 0.09; 0.62,P = 0.003,I2 = 0%)和器官衰竭(RR = 0.67,95% CI = 0.48; 0.93,P = 0.02,I2 = 78%)方面,LMWH优于标准治疗。与对照组相比,干预组在胃肠道出血(RR = 0.64,95% CI = 0.44; 0.94,P = 0.02,I2 = 0%)、住院时间(MD= - 6.08,95% CI = - 10.08; - 2.07,P = 0.003,I2 = 98%)、手术干预需求(RR = 0.50,95% CI = 0.29; 0.87,P = 0.01,I2 = 61%)和血管血栓形成(RR = 0.43,95% CI = 0.31; 0.61,P < 0.00001,I2 = 0%)。中度至高质量证据表明,早期使用 LMWH 干预可改善非轻度 AP 的预后,降低死亡率、器官衰竭和血管血栓形成的发生率。鉴于我们的研究结果,建议将 LMWH 纳入中重度至重度 AP 的治疗方案中。
{"title":"Effectiveness and safety of low molecular weight heparin in the management of acute pancreatitis: a systematic review and meta-analysis","authors":"Mauro Podda, Valentina Murzi, Paola Marongiu, Marcello Di Martino, Belinda De Simone, Kumar Jayant, Monica Ortenzi, Federico Coccolini, Massimo Sartelli, Fausto Catena, Benedetto Ielpo, Adolfo Pisanu","doi":"10.1186/s13017-024-00558-3","DOIUrl":"https://doi.org/10.1186/s13017-024-00558-3","url":null,"abstract":"Recent studies suggest that low-molecular-weight heparin (LMWH) may play a role in mitigating the severity of acute pancreatitis (AP). This systematic review and meta-analysis aims to synthesise existing evidence on the effectiveness and safety of LMWH in the treatment of moderately-severe and severe AP. This systematic review and meta-analysis was conducted in accordance with the 2020 update of the PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. The systematic search was conducted in MEDLINE, the Cochrane Central Register of Controlled Trials, Scopus, and EMBASE, covering studies published up to February 2024. Randomised controlled trials (RCTs) and observational studies (n-RCTs) that reported the differences in the outcomes of AP for patients receiving LMWH in addition to the standard treatment (Intervention), compared to patients managed by standard treatment without LMWH (Control) were eligible. A random-effects model was used to calculate the pooled relative risk (RR) and mean differences (MD) with the corresponding 95% CI. Thirteen studies were included in the meta-analysis, all published between 2004 and 2022. Eight studies were RCTs, and five were n-RCTs. Data from 13,709 patients (6.971 Interventions and 6.738 Controls) were analysed. The comparison of Intervention and Control groups showed the superiority of LMWH to standard treatments in terms of overall mortality (RR = 0.44, 95% CI = 0.31; 0.64, P < 0.0001, I2 = 51%), acute necrotic collections (RR = 0.24, 95% CI = 0.09; 0.62, P = 0.003, I2 = 0%), and organ failure (RR = 0.67, 95% CI = 0.48; 0.93, P = 0.02, I2 = 78%). The Intervention group showed superior outcomes compared with the Control group for gastrointestinal bleeding (RR = 0.64, 95% CI = 0.44; 0.94, P = 0.02, I2 = 0%), length of hospital stay (MD= − 6.08, 95% CI = − 10.08; − 2.07, P = 0.003, I2 = 98%), need for operative interventions (RR = 0.50, 95% CI = 0.29; 0.87, P = 0.01, I2 = 61%), and vascular thrombosis (RR = 0.43, 95% CI = 0.31; 0.61, P < 0.00001, I2 = 0%). Moderate to high-quality evidence suggests that early intervention with LMWH could improve the prognosis of non-mild AP in terms of mortality, organ failure, and decreased incidence of vascular thrombosis. In light of our findings, integrating LMWH into the treatment regimen for moderate-severe to severe AP is advocated.","PeriodicalId":48867,"journal":{"name":"World Journal of Emergency Surgery","volume":"48 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142160661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring aortic morphology and determining variable-distance insertion lengths for fluoroscopy-free resuscitative endovascular balloon occlusion of the aorta (REBOA) 探索主动脉形态并确定无透视复苏主动脉血管内球囊闭塞术(REBOA)的可变距离插入长度
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-08-31 DOI: 10.1186/s13017-024-00557-4
Jan C. van de Voort, Barbara B. Verbeek, Boudewijn L.S. Borger van der Burg, Rigo Hoencamp
Resuscitative endovascular balloon occlusion of the aorta (REBOA) is used to temporary control non-compressible truncal hemorrhage (NCTH) as bridge to definitive surgical treatment. The dependence on radiography for safe balloon positioning is one factor that limits the extended use of REBOA in civilian and military pre-hospital settings. We aimed to determine standardized sex and age-based variable-distance catheter insertion lengths for accurate REBOA placement without initial fluoroscopic confirmation. Contrast enhanced CT-scans from a representative sample of a Dutch non-trauma population were retrospectively analyzed. Intravascular distances were measured from the bilateral common femoral artery access points (FAAP) to the middle of the aortic occlusion zones and accompanying boundaries. Means and 95% confidence intervals for the distances from the FAAPs to the boundaries and mid-zone III were calculated for all (combined) sex and age-based subgroups. Optimal insertion lengths and potentially safe regions were determined for these groups. Bootstrap analysis was performed in combination with a 40-mm long balloon introduction simulation to determine error-rates and REBOA placement accuracy for the general population. In total, 1354 non-trauma patients (694 females) were included. Vascular distances increased with age and were longer in males. The iliofemoral trajectory was 7 mm longer on the right side. The optimal zone I catheter insertion length would be 430 mm. Optimal zone III catheter insertion lengths showed up to 30 mm difference, ranging between 234 and 264 mm. Statistically significant and potentially clinically relevant differences were observed between the anatomical distances and necessary introduction depths for each subgroup. This is the first study to compare aortic morphology and intravascular distances between combined sex and age-based subgroups. As zone III length was consistent, length variability and elongation seem to mainly originate in the iliofemoral trajectory and zone II. The optimal zone I catheter insertion length would be 430 mm. Optimal zone III catheter insertion ranged between 234 and 264 mm. These standardized variable-distance insertion lengths could facilitate safer fluoroscopy-free REBOA in austere, pre-hospital settings.
主动脉血管内球囊闭塞复苏术(REBOA)用于暂时控制非可压缩性截动脉出血(NCTH),为最终手术治疗架起桥梁。在民用和军用院前环境中,REBOA 的广泛使用受到一个因素的限制,那就是球囊的安全定位依赖于放射成像。我们的目的是确定基于性别和年龄的标准化可变距离导管插入长度,以便在没有初始透视确认的情况下准确放置 REBOA。我们对来自荷兰非创伤人群的代表性样本的对比增强 CT 扫描进行了回顾性分析。测量了从双侧股总动脉入路点(FAAP)到主动脉闭塞区中间及其边界的血管内距离。计算了所有(合并的)性别和年龄亚组从股总动脉接入点到边界和III区中部的距离的平均值和95%置信区间。确定了这些分组的最佳插入长度和潜在安全区域。结合 40 毫米长球囊导入模拟进行了 Bootstrap 分析,以确定一般人群的误差率和 REBOA 置放准确性。共纳入 1354 名非创伤患者(694 名女性)。血管距离随年龄增长而增加,男性血管距离更长。右侧髂股动脉轨迹长 7 毫米。I 区最佳导管插入长度为 430 毫米。III 区最佳导管插入长度最多相差 30 毫米,介于 234 毫米和 264 毫米之间。每个亚组的解剖学距离和必要的导入深度之间都存在明显的统计学差异,并可能与临床相关。这是第一项比较不同性别和年龄亚组之间主动脉形态和血管内距离的研究。由于 III 区长度一致,长度变异和伸长似乎主要源于髂股径和 II 区。I 区导管的最佳插入长度为 430 毫米。III 区导管的最佳插入长度在 234 至 264 毫米之间。这些标准化的可变距离插入长度有助于在院前环境中进行更安全的无透视 REBOA。
{"title":"Exploring aortic morphology and determining variable-distance insertion lengths for fluoroscopy-free resuscitative endovascular balloon occlusion of the aorta (REBOA)","authors":"Jan C. van de Voort, Barbara B. Verbeek, Boudewijn L.S. Borger van der Burg, Rigo Hoencamp","doi":"10.1186/s13017-024-00557-4","DOIUrl":"https://doi.org/10.1186/s13017-024-00557-4","url":null,"abstract":"Resuscitative endovascular balloon occlusion of the aorta (REBOA) is used to temporary control non-compressible truncal hemorrhage (NCTH) as bridge to definitive surgical treatment. The dependence on radiography for safe balloon positioning is one factor that limits the extended use of REBOA in civilian and military pre-hospital settings. We aimed to determine standardized sex and age-based variable-distance catheter insertion lengths for accurate REBOA placement without initial fluoroscopic confirmation. Contrast enhanced CT-scans from a representative sample of a Dutch non-trauma population were retrospectively analyzed. Intravascular distances were measured from the bilateral common femoral artery access points (FAAP) to the middle of the aortic occlusion zones and accompanying boundaries. Means and 95% confidence intervals for the distances from the FAAPs to the boundaries and mid-zone III were calculated for all (combined) sex and age-based subgroups. Optimal insertion lengths and potentially safe regions were determined for these groups. Bootstrap analysis was performed in combination with a 40-mm long balloon introduction simulation to determine error-rates and REBOA placement accuracy for the general population. In total, 1354 non-trauma patients (694 females) were included. Vascular distances increased with age and were longer in males. The iliofemoral trajectory was 7 mm longer on the right side. The optimal zone I catheter insertion length would be 430 mm. Optimal zone III catheter insertion lengths showed up to 30 mm difference, ranging between 234 and 264 mm. Statistically significant and potentially clinically relevant differences were observed between the anatomical distances and necessary introduction depths for each subgroup. This is the first study to compare aortic morphology and intravascular distances between combined sex and age-based subgroups. As zone III length was consistent, length variability and elongation seem to mainly originate in the iliofemoral trajectory and zone II. The optimal zone I catheter insertion length would be 430 mm. Optimal zone III catheter insertion ranged between 234 and 264 mm. These standardized variable-distance insertion lengths could facilitate safer fluoroscopy-free REBOA in austere, pre-hospital settings.","PeriodicalId":48867,"journal":{"name":"World Journal of Emergency Surgery","volume":"2017 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emergency robotic surgery: the experience of a single center and review of the literature 急诊机器人手术:单个中心的经验和文献综述
IF 8 1区 医学 Q1 EMERGENCY MEDICINE Pub Date : 2024-08-17 DOI: 10.1186/s13017-024-00555-6
Graziano Ceccarelli, Fausto Catena, Pasquale Avella, Brian WCA Tian, Fabio Rondelli, Germano Guerra, Michele De Rosa, Aldo Rocca
Laparoscopic surgery is widely used in abdominal emergency surgery (AES), and the possibility of extending this approach to the more recent robotic surgery (RS) arouses great interest. The slow diffusion of robotic technology mainly due to high costs and the longer RS operative time when compared to laparoscopy may represent disincentives, especially in AES. This study aims to report our experience in the use of RS in AES assessing its safety and feasibility, with particular focus on intra- and post-operative complications, conversion rate, and surgical learning curve. Our data were also compared to other experiences though an extensive literature review. We retrospectively analysed a single surgeon series of the last 10 years. From January 2014 to December 2023, 36 patients underwent urgent or emergency RS. The robotic devices used were Da Vinci Si (15 cases) and Xi (21 cases). 36 (4.3%) out of 834 robotic procedures were included in our analysis: 20 (56.56%) females. The mean age was 63 years and 30% of patients were ≥ 70 years. 2 (5.55%) procedures were performed at night. No conversions to open were reported in this series. According to the Clavien-Dindo classification, 2 (5.5%) major complications were collected. Intraoperative and 30-day mortality were 0%. Our study demonstrates that RS may be a useful and reliable approach also to AES and intraoperative laparoscopic complications when performed in selected hemodynamically stable patients in very well-trained robotic centers. The technology may increase the minimally invasive use and conversion rate in emergent settings in a completely robotic or hybrid approach.
腹腔镜手术被广泛应用于腹部急诊手术(AES),而将这种方法推广到最新的机器人手术(RS)的可能性引起了人们的极大兴趣。机器人技术推广缓慢的主要原因是成本高,而且与腹腔镜手术相比,RS手术时间更长,这可能是阻碍其推广的因素,尤其是在腹部急诊手术中。本研究旨在报告我们在 AES 中使用 RS 的经验,评估其安全性和可行性,尤其关注术中和术后并发症、转换率和手术学习曲线。我们还通过广泛的文献回顾,将我们的数据与其他经验进行了比较。我们回顾性分析了过去 10 年中的单个外科医生系列。从2014年1月到2023年12月,36名患者接受了紧急或急诊RS手术。使用的机器人设备是达芬奇 Si(15 例)和 Xi(21 例)。在834例机器人手术中,有36例(4.3%)纳入了我们的分析:其中20例(56.56%)为女性。平均年龄为 63 岁,30% 的患者年龄超过 70 岁。2例(5.55%)手术在夜间进行。该系列手术中没有转为开放手术的报告。根据克拉维恩-丁多(Clavien-Dindo)分类法,共收集到2例(5.5%)主要并发症。术中死亡率和 30 天死亡率均为 0%。我们的研究表明,如果在训练有素的机器人中心对选定的血流动力学稳定的患者进行手术,RS也可能是治疗AES和术中腹腔镜并发症的一种有用而可靠的方法。该技术可能会增加微创手术的使用率,并提高完全机器人或混合方法在紧急情况下的转换率。
{"title":"Emergency robotic surgery: the experience of a single center and review of the literature","authors":"Graziano Ceccarelli, Fausto Catena, Pasquale Avella, Brian WCA Tian, Fabio Rondelli, Germano Guerra, Michele De Rosa, Aldo Rocca","doi":"10.1186/s13017-024-00555-6","DOIUrl":"https://doi.org/10.1186/s13017-024-00555-6","url":null,"abstract":"Laparoscopic surgery is widely used in abdominal emergency surgery (AES), and the possibility of extending this approach to the more recent robotic surgery (RS) arouses great interest. The slow diffusion of robotic technology mainly due to high costs and the longer RS operative time when compared to laparoscopy may represent disincentives, especially in AES. This study aims to report our experience in the use of RS in AES assessing its safety and feasibility, with particular focus on intra- and post-operative complications, conversion rate, and surgical learning curve. Our data were also compared to other experiences though an extensive literature review. We retrospectively analysed a single surgeon series of the last 10 years. From January 2014 to December 2023, 36 patients underwent urgent or emergency RS. The robotic devices used were Da Vinci Si (15 cases) and Xi (21 cases). 36 (4.3%) out of 834 robotic procedures were included in our analysis: 20 (56.56%) females. The mean age was 63 years and 30% of patients were ≥ 70 years. 2 (5.55%) procedures were performed at night. No conversions to open were reported in this series. According to the Clavien-Dindo classification, 2 (5.5%) major complications were collected. Intraoperative and 30-day mortality were 0%. Our study demonstrates that RS may be a useful and reliable approach also to AES and intraoperative laparoscopic complications when performed in selected hemodynamically stable patients in very well-trained robotic centers. The technology may increase the minimally invasive use and conversion rate in emergent settings in a completely robotic or hybrid approach.","PeriodicalId":48867,"journal":{"name":"World Journal of Emergency Surgery","volume":"36 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141994520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
World Journal of Emergency Surgery
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1