应用进化错配框架来理解疾病易感性。

IF 7.8 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY PLoS Biology Pub Date : 2023-09-11 eCollection Date: 2023-09-01 DOI:10.1371/journal.pbio.3002311
Amanda J Lea, Andrew G Clark, Andrew W Dahl, Orrin Devinsky, Angela R Garcia, Christopher D Golden, Joseph Kamau, Thomas S Kraft, Yvonne A L Lim, Dino J Martins, Donald Mogoi, Päivi Pajukanta, George H Perry, Herman Pontzer, Benjamin C Trumble, Samuel S Urlacher, Vivek V Venkataraman, Ian J Wallace, Michael Gurven, Daniel E Lieberman, Julien F Ayroles
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引用次数: 0

摘要

非传染性疾病在全球范围内呈上升趋势。肥胖、心血管疾病和2型糖尿病是一长串“生活方式”疾病之一,这些疾病在人类历史上很罕见,但现在很常见。进化错配假说认为,人类在与我们目前经历的环境截然不同的环境中进化;因此,曾经有利的特征现在可能“不匹配”并导致疾病。在遗传水平上,这一假设预测,有选择史的基因座将表现出“逐环境基因型”(GxE)的相互作用,在“祖先”和“现代”环境中具有不同的健康影响。为了识别这些基因座,我们主张将基因组工具与生活方式快速改变的生存水平群体相结合。在这些人群中,将处于“匹配”和“不匹配”光谱相反极端的个体进行比较是唯一可能的。更广泛地说,我们提出的工作将有助于我们理解不同祖先和文化的非传染性疾病的环境和遗传风险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Applying an evolutionary mismatch framework to understand disease susceptibility.

Noncommunicable diseases (NCDs) are on the rise worldwide. Obesity, cardiovascular disease, and type 2 diabetes are among a long list of "lifestyle" diseases that were rare throughout human history but are now common. The evolutionary mismatch hypothesis posits that humans evolved in environments that radically differ from those we currently experience; consequently, traits that were once advantageous may now be "mismatched" and disease causing. At the genetic level, this hypothesis predicts that loci with a history of selection will exhibit "genotype by environment" (GxE) interactions, with different health effects in "ancestral" versus "modern" environments. To identify such loci, we advocate for combining genomic tools in partnership with subsistence-level groups experiencing rapid lifestyle change. In these populations, comparisons of individuals falling on opposite extremes of the "matched" to "mismatched" spectrum are uniquely possible. More broadly, the work we propose will inform our understanding of environmental and genetic risk factors for NCDs across diverse ancestries and cultures.

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来源期刊
PLoS Biology
PLoS Biology 生物-生化与分子生物学
CiteScore
14.40
自引率
2.00%
发文量
359
审稿时长
3 months
期刊介绍: PLOS Biology is an open-access, peer-reviewed general biology journal published by PLOS, a nonprofit organization of scientists and physicians dedicated to making the world's scientific and medical literature freely accessible. The journal publishes new articles online weekly, with issues compiled and published monthly. ISSN Numbers: eISSN: 1545-7885 ISSN: 1544-9173
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