不同器官转移的发生率及其对 NSCLC 预后的影响

IF 1.3 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Thoracic and Cardiovascular Surgeon Pub Date : 2024-04-01 Epub Date: 2023-08-02 DOI:10.1055/a-2146-6879
Shenhai Wei, Wenchao Wei, Bingqun Wu, Jintao Tian, Pengcheng Hu, Shouqiang Pan, Xiaoping Song
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引用次数: 0

摘要

目的:本研究旨在探讨不同器官转移对非小细胞肺癌(NSCLC)预后的影响:本研究旨在探讨不同器官转移对非小细胞肺癌(NSCLC)预后的影响:方法:从2016年至2019年期间的监测、流行病学和最终结果数据库中选取远处转移的NSCLC患者。探讨了不同器官转移的发生率及其与临床病理因素的关系。计算了转移性NSCLC的总生存期(OS)和肺癌特异性生存期(LCSS),并进行了多变量Cox回归分析,在Cox回归的基础上构建了OS的提名图:本研究共纳入了 26210 例远处转移 NSCLC 患者。约48.9%的转移性NSCLC为多器官转移,骨是最常见的受累器官(44.4%)。在单器官转移患者中,肺转移或远处淋巴结转移的预后优于其他器官(肺转移和远处淋巴结转移的中位生存期分别为15个月和16个月),肝转移的预后最差,中位生存期为8个月。研究人员绘制了Cox回归模型的显示图,并绘制了接收者操作特征曲线(ROC),结果表明该预测模型具有良好的辨别能力,1年和2年的ROC曲线下面积分别为0.687和0.702:结论:有远处转移的NSCLC患者预后较差。结论:NSCLC 远处转移患者的预后较差,其中肝转移是单器官转移中预后最差的。基于Cox回归模型开发的提名图为估计转移性NSCLC的OS概率提供了有用的工具。
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The Incidence and Effect of Different Organ Metastasis on the Prognosis of NSCLC.

Objective:  The aim of this study was to explore the effect of different organ metastasis on the prognosis of non-small cell lung cancer (NSCLC).

Methods:  Patients with distant metastatic NSCLC were selected from Surveillance, Epidemiology, and End Results database during 2016 to 2019. The incidence of different organ metastasis and their association with clinicopathological factors were explored. Overall survival (OS) and lung cancer-specific survival (LCSS) for metastatic NSCLC were calculated, and multivariate Cox regression analysis was performed with a nomogram for OS being constructed based on Cox regression.

Results:  Total 26,210 patients with distant metastatic NSCLC were included in this study. Around 48.9% of the metastatic NSCLC were multiple-organ metastasis and bone was the most commonly involved organ (44.4%). For patients with single-organ metastasis, the prognosis for lung or distant lymph nodes (LNs) metastasis was better than others (with median OS of 15 and 16 months for lung and distant LNs metastasis, respectively), and liver metastasis resulted in the worst prognosis with median OS of 8 months. A nomogram was constructed to visualize Cox regression model, along with the receiver operating characteristic (ROC) curve demonstrated good discrimination for the predictive model with 1- and 2-year area under the curve of ROC of 0.687 and 0.702, respectively.

Conclusion:  The prognosis of NSCLC patients with distant metastasis was poor. Liver metastasis results in the worst prognosis among the single-organ metastasis. The nomogram developed based on the Cox regression model has provided a useful tool to estimate the probability of OS of the metastatic NSCLC.

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来源期刊
CiteScore
3.40
自引率
6.70%
发文量
365
审稿时长
3 months
期刊介绍: The Thoracic and Cardiovascular Surgeon publishes articles of the highest standard from internationally recognized thoracic and cardiovascular surgeons, cardiologists, anesthesiologists, physiologists, and pathologists. This journal is an essential resource for anyone working in this field. Original articles, short communications, reviews and important meeting announcements keep you abreast of key clinical advances, as well as providing the theoretical background of cardiovascular and thoracic surgery. Case reports are published in our Open Access companion journal The Thoracic and Cardiovascular Surgeon Reports.
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