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The Impact of Multiarterial Grafting in Patients with Left Ventricular Dysfunction. 多动脉移植对左心室功能障碍患者的影响
IF 1.3 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-21 DOI: 10.1055/a-2446-9960
Tom Ronai, Dana Abraham, Ely Erez, Guy Witberg, Yaron Yishai, Erez Sharoni, Dror B Leviner

Background:  Coronary artery bypass grafting (CABG) is one of the revascularization modalities available in patients with left ventricular dysfunction (LVD). Multiple arterial grafting (MAG) is associated with improved long-term outcomes. Data on the benefits of MAG in patients with LVD are limited. We examined the effect of MAG on outcomes across the spectrum of left ventricle (LV) function.

Methods:  Retrospective cohort study of patients undergoing isolated CABG (January 1, 2009, to October 1, 2021). Patients were grouped according to revascularization strategy (single vs. MAG). The primary outcome was a composite of all-cause mortality, cerebrovascular accident, myocardial infarction, and repeat revascularization (major adverse cardiac and cerebrovascular events [MACCE]). The cumulative incidence of MACCE was plotted using Kaplan-Meier curves. Results were stratified according to LV function (<30%, 30-50%, >50%).

Results:  Our cohort included 4,763 patients; 1,976 (41.4%) underwent single arterial grafting (SAG), and 2,787 (58.6%) underwent MAG; 3,976 (83.4%) were male with a median age of 64 (interquartile range [IQR] 57-71) years. Distribution of LV function was 2,539 (53.3%) with an ejection fraction (EF) >50%, 1,828 (38.3%) with an EF of 30-50%, and 396 (8.3%) with an EF <30%. Median follow-up time was 64 (37-102) months. Cumulative incidence of MACCE at 72 months was 28.7% in the MAG and 30.3% in the SAG group. Stratified by LV function, the hazard ratio for MACCE at 160 months was 0.71 (95% CI 0.54-0.93), 0.78 (95% CI 0.68-0.9), and 0.95 (95% CI 0.83-1.09) for LV function <30%, 30-50%, >50%, respectively, with no significant interaction between MAG and LV function.

Conclusion:  MAG is associated with improved outcomes following CABG across the spectrum of LV function.

背景:冠状动脉旁路移植术(CABG)是左心室功能障碍(LVD)患者可采用的血管重建方式之一。多支动脉移植术(MAG)可改善长期预后。有关多支动脉移植对 LVD 患者益处的数据还很有限。我们研究了MAG对左心室(LV)功能各方面预后的影响:对接受孤立 CABG(2009 年 1 月 1 日至 2021 年 10 月 1 日)的患者进行回顾性队列研究。根据血管再通策略(单次与 MAG)对患者进行分组。主要研究结果是全因死亡率、脑血管意外、心肌梗死和重复血管再通(主要心脑血管不良事件 [MACCE])的综合结果。MACCE 的累积发生率采用 Kaplan-Meier 曲线绘制。结果根据左心室功能(50%)进行分层:我们的队列包括 4,763 名患者,其中 1,976 人(41.4%)接受了单动脉移植术 (SAG),2,787 人(58.6%)接受了 MAG;3,976 人(83.4%)为男性,中位年龄为 64 岁(四分位数间距 [IQR] 57-71)。左心室功能分布情况为:射血分数(EF)>50%的有2539人(53.3%),EF为30%-50%的有1828人(38.3%),EF为50%的有396人(8.3%),MAG与左心室功能之间无显著交互作用:结论:无论左心室功能如何,MAG 都与 CABG 术后预后的改善相关。
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引用次数: 0
Crural Diaphragm Density in Respiratory Complications after Video-Assisted Thoracoscopic Surgery Lobectomy. 视频辅助胸腔镜手术肺叶切除术后呼吸道并发症的胸膜膈肌密度。
IF 1.3 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-19 DOI: 10.1055/a-2446-9756
Alice Bellini, Antonio Vizzuso, Sara Sterrantino, Angelo Paolo Ciarrocchi, Sara Piciucchi, Emanuela Giampalma, Franco Stella

Background:  Respiratory muscle strength affects pulmonary function after lung resection; however, the role of diaphragm density, an emerging index of muscle quality, remains unexplored. We investigated the role of crural diaphragm density (CDD) in respiratory complications (RC) after video-assisted thoracoscopic surgery (VATS) lobectomy for lung cancer.

Methods:  A total of 118 patients were retrospectively enrolled between 2015 and 2022. Exclusion criteria were neoadjuvant therapy, thoracic trauma, and previous cardiothoracic and abdominal surgery. Demographic, functional, and radiological data were collected. The CDD in Hounsfield Unit (HU) was defined as the average of the density of the right and left crural diaphragm at the level of the median arcuate ligament on computed tomography axial images. RC included sputum retention, respiratory infections, atelectasis, pneumonia, respiratory failure, and acute respiratory distress syndrome.

Results:  The prevalence of postoperative RC was 41% (48 of 118). RC occurred mostly in males (64.6 vs. 44.3%, p = 0.04), current smokers (41.7 vs. 21.4%, p = 0.02), a longer surgical procedure (210 vs. 180 minutes, p = 0.04), and a lower CDD (42.5 vs. 48 HU, p = 0.05). The optimal cutoff of CDD was 39.75 HU (sensitivity 43%, specificity 82%, accuracy 65%, area under the curve: 0.62, p = 0.05), slightly above the threshold for reduced muscle mass (<30 HU). By multivariable logistic regression a CDD ≤ 39.75 HU (hazard ratio [HR]: 3.134 [95% confidence interval, CI: 1.111-8.844], p = 0.03) and current smoking (HR: 2.733 [95% CI: 1.012-7.380], p = 0.05) were both independent risk factors of postoperative RC.

Conclusion:  The CDD seems to be a simple and useful tool for predicting RC after VATS lobectomy, especially among current smokers. Such patients, identified early, could benefit from preoperative functional and nutritional rehabilitation.

背景:呼吸肌力量会影响肺切除术后的肺功能;然而,横膈膜密度作为肌肉质量的新指标,其作用仍未得到探讨。我们研究了膈肌密度(CDD)在肺癌视频辅助胸腔镜手术(VATS)肺叶切除术后呼吸系统并发症(RC)中的作用:在2015年至2022年期间,共回顾性登记了118例患者。排除标准为新辅助治疗、胸部创伤以及既往接受过心胸外科和腹部手术。收集了人口统计学、功能和放射学数据。以 Hounsfield 单位(HU)为单位的 CDD 被定义为计算机断层扫描轴向图像上正中弓状韧带水平的左右胸膈密度的平均值。RC包括痰液潴留、呼吸道感染、肺不张、肺炎、呼吸衰竭和急性呼吸窘迫综合征:术后 RC 的发生率为 41%(118 例中有 48 例)。RC主要发生在男性(64.6% 对 44.3%,P = 0.04)、吸烟者(41.7% 对 21.4%,P = 0.02)、手术时间较长(210 分钟对 180 分钟,P = 0.04)和 CDD 较低(42.5 HU 对 48 HU,P = 0.05)的人群中。CDD 的最佳临界值为 39.75 HU(灵敏度为 43%,特异性为 82%,准确度为 65%,曲线下面积为 0.62,p = 0.05):0.62,p = 0.05),略高于肌肉质量减少的临界值(p = 0.03),目前吸烟(HR:2.733 [95% CI:1.012-7.380],p = 0.05)都是术后 RC 的独立危险因素:CDD似乎是预测VATS肺叶切除术后RC的一个简单而有用的工具,尤其是对目前吸烟的患者而言。早期发现的此类患者可从术前功能和营养康复中获益。
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引用次数: 0
Long-term Survival in Elderly Patients after Coronary Artery Bypass Grafting Compared to the Age-matched General Population: A Meta-analysis of Reconstructed Time-to-Event Data. 与年龄匹配的普通人群相比,冠状动脉旁路移植术后老年患者的长期生存率:重建事件发生时间数据的 Meta 分析。
IF 1.3 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-19 DOI: 10.1055/s-0044-1789238
Hristo Kirov, Tulio Caldonazo, Sultonbek Toshmatov, Panagiotis Tasoudis, Murat Mukharyamov, Mahmoud Diab, Torsten Doenst

Background:  Coronary artery disease (CAD) limits life expectancy compared to the general population. Myocardial infarctions (MIs) are the primary cause of death. The incidence of MI increases progressively with age and most MI deaths occur in the population older than 70 years. Coronary artery bypass grafting (CABG) may prevent the occurrence of new MIs by bypassing most CAD lesions, providing downstream "collateralization" to the diseased vessel, and consequently prolonging survival. We systematically assessed the survival-improving potential of CABG by comparing elderly CABG patients to the age-matched general population.

Methods:  Three databases were assessed. The primary and single outcome was long-term all-cause mortality. Time-to-event data of the individual studies were extracted and reconstructed in an overall survival curve. As a sensitivity analysis, summary hazard ratios (HRs) and 95% confidence intervals (CIs) for all individual studies were pooled and meta-analytically addressed. The control group was based on the age-matched general population of each individual study.

Results:  From 1,352 records, 4 studies (4,045 patients) were included in the analysis. Elderly patients (>70 years) who underwent CABG had a significantly lower risk of death in the follow-up compared to the general age-matched population in the overall survival analysis (HR: 0.88; 95% CI: 0.83, 0.94; p < 0.001: mean follow-up was 7 years).

Conclusion:  Elderly patients who undergo CABG appear to have significantly better long-term survival compared to the age-matched general population. This advantage becomes visible after the first year and underscores the life-prolonging effect of bypass surgery, which may eliminate the expected reduction in life expectancy through CAD.

背景:与普通人相比,冠状动脉疾病(CAD)限制了人们的预期寿命。心肌梗塞(MI)是导致死亡的主要原因。心肌梗塞的发病率随着年龄的增长而逐渐增加,大多数心肌梗塞死亡病例发生在 70 岁以上的人群中。冠状动脉旁路移植术(CABG)可绕过大多数 CAD 病变,为病变血管提供下游 "侧支",从而预防新的心肌梗死的发生,并因此延长存活时间。我们通过比较老年冠脉搭桥术患者和年龄匹配的普通人群,系统地评估了冠脉搭桥术提高生存率的潜力:方法:评估了三个数据库。方法:对三个数据库进行了评估,主要和唯一的结果是长期全因死亡率。提取了各项研究的时间到事件数据,并重建了总生存率曲线。作为一项敏感性分析,对所有单项研究的汇总危险比(HRs)和 95% 置信区间(CIs)进行了汇总和元分析处理。对照组以每项研究中年龄匹配的普通人群为基础:从 1,352 份记录中,有 4 项研究(4,045 名患者)被纳入分析。在总生存率分析中,接受心血管造影术的老年患者(大于 70 岁)在随访期间的死亡风险明显低于年龄匹配的普通人群(HR:0.88;95% CI:0.83, 0.94;P 结论:接受心血管造影术的老年患者在随访期间的死亡风险明显低于年龄匹配的普通人群(HR:0.88;95% CI:0.83, 0.94):与年龄匹配的普通人群相比,接受心血管造影术的老年患者的长期生存率明显更高。这种优势在第一年后就会显现出来,并强调了搭桥手术的延寿效果,它可能会消除因CAD导致的预期寿命缩短。
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引用次数: 0
Off-Pump Revascularization in Moderate Ischemic Mitral Regurgitation. 中度缺血性二尖瓣反流的泵外血管重建术
IF 1.3 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-19 DOI: 10.1055/a-2444-9602
Mehmet Sanser Ates, Gulen Sezer Alptekin, Zumrut Tuba Demirozu, Yilmaz Zorman, Atif Akcevin

Background:  Ischemic mitral regurgitation (IMR) is associated with high mortality and poor outcomes. The surgical management of moderate IMR is still an object of debate.

Methods:  Patients with moderate IMR who underwent isolated off-pump coronary bypass grafting (OPCAB) with facile stabilization between January 2015 and February 2022 were analyzed. The primary endpoint was the remaining IMR and echocardiographic findings while the secondary outcomes were defined as mortality, major adverse events, and postoperative functional status.

Results:  Of 541 patients who underwent isolated OPCAB in this period, there were 62 patients with concomitant moderate IMR. The mean follow-up period was 19.4 ± 21.6 months. The median number of the coronary anastomosis was 4. In 58.06% (n = 36), the regurgitation regressed. Left atrial (LA) diameter significantly decreased postoperatively (p = 0.040). Increased LA diameter was associated with increased major adverse events (p = 0.010). Rehospitalization rates were higher in low ejection fraction (EF). The postoperative poor functional status (New York Heart Association [NYHA] III-IV) was correlated with an increased postoperative left ventricular end-systolic diameter (LVESD; 41.75 ± 6.13 vs. 34.79 ± 6.8 mm, p = 0.05). Mortality (4.8%, n = 3) was associated with older age and increased preoperative systolic pulmonary artery pressure (PAP; p = 0.050 and p = 0.046, respectively).

Conclusion:  LA diameter, LVESD, mean systolic PAP, left ventricular ejection fraction (LVEF), and age are important predictors for outcomes in IMR. Remaining IMR per se is not directly correlated with increased mortality and major adverse cardiac and cerebrovascular events. The facile stabilization technique we used appears to be advantageous due to the feasibility of full revascularization of all intended vessels, particularly of the inferoposterior wall by providing excellent vision without compression of the heart.

背景:缺血性二尖瓣反流(IMR)与高死亡率和不良预后相关。中度二尖瓣反流的手术治疗仍是争论的焦点:方法:分析了2015年1月至2022年2月期间接受分离式无泵冠状动脉旁路移植术(OPCAB)且术后情况稳定的中度IMR患者。主要终点是剩余的缺血性二尖瓣反流和超声心动图结果,次要结果是死亡率、主要不良事件和术后功能状态:在此期间接受孤立 OPCAB 的 541 名患者中,有 62 名患者同时伴有中度 IMR。平均随访时间为(19.4±21.6)个月。冠状动脉吻合次数的中位数为 4 次(1-6 次)。58.06%(36 人)的反流症状得到缓解。术后左心房(LA)直径明显缩小(p= .040)。LA 直径增大与主要不良事件增加有关(p=.010)。EF值低的患者再住院率更高。术后不良功能状态(NYHA III-IV)与术后左心室收缩末期直径增大相关(41.75±6.13 v.s. 34.79±6.8,P=.05)。死亡率(4.8%,n=3)与年龄较大和术前肺动脉收缩压升高有关(分别为p= .050;p= .046):结论:LA直径、LVESD、平均收缩肺动脉压、LVEF和年龄是IMR预后的重要预测因素。剩余IMR本身与死亡率和MACCE的增加并无直接关联。我们在此采用的简便稳定技术具有优势,因为它可以在不压迫心脏的情况下提供良好的视野,对所有预定血管尤其是后壁血管进行全面再通。
{"title":"Off-Pump Revascularization in Moderate Ischemic Mitral Regurgitation.","authors":"Mehmet Sanser Ates, Gulen Sezer Alptekin, Zumrut Tuba Demirozu, Yilmaz Zorman, Atif Akcevin","doi":"10.1055/a-2444-9602","DOIUrl":"10.1055/a-2444-9602","url":null,"abstract":"<p><strong>Background: </strong> Ischemic mitral regurgitation (IMR) is associated with high mortality and poor outcomes. The surgical management of moderate IMR is still an object of debate.</p><p><strong>Methods: </strong> Patients with moderate IMR who underwent isolated off-pump coronary bypass grafting (OPCAB) with facile stabilization between January 2015 and February 2022 were analyzed. The primary endpoint was the remaining IMR and echocardiographic findings while the secondary outcomes were defined as mortality, major adverse events, and postoperative functional status.</p><p><strong>Results: </strong> Of 541 patients who underwent isolated OPCAB in this period, there were 62 patients with concomitant moderate IMR. The mean follow-up period was 19.4 ± 21.6 months. The median number of the coronary anastomosis was 4. In 58.06% (<i>n</i> = 36), the regurgitation regressed. Left atrial (LA) diameter significantly decreased postoperatively (<i>p</i> = 0.040). Increased LA diameter was associated with increased major adverse events (<i>p</i> = 0.010). Rehospitalization rates were higher in low ejection fraction (EF). The postoperative poor functional status (New York Heart Association [NYHA] III-IV) was correlated with an increased postoperative left ventricular end-systolic diameter (LVESD; 41.75 ± 6.13 vs. 34.79 ± 6.8 mm, <i>p</i> = 0.05). Mortality (4.8%, <i>n</i> = 3) was associated with older age and increased preoperative systolic pulmonary artery pressure (PAP; <i>p</i> = 0.050 and <i>p</i> = 0.046, respectively).</p><p><strong>Conclusion: </strong> LA diameter, LVESD, mean systolic PAP, left ventricular ejection fraction (LVEF), and age are important predictors for outcomes in IMR. Remaining IMR per se is not directly correlated with increased mortality and major adverse cardiac and cerebrovascular events. The facile stabilization technique we used appears to be advantageous due to the feasibility of full revascularization of all intended vessels, particularly of the inferoposterior wall by providing excellent vision without compression of the heart.</p>","PeriodicalId":23057,"journal":{"name":"Thoracic and Cardiovascular Surgeon","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unpredictable Aortic Behavior in Identifying Risk Factors for Reintervention: A Prospective Cohort Study. 识别再介入风险因素的不可预测主动脉行为:前瞻性队列研究
IF 1.3 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-18 DOI: 10.1055/s-0044-1791947
Mohamed Eraqi, Tamer Ghazy, Tiago Cerqueira, Jennifer Lynne Leip, Timo Siepmann, Adrian Mahlmann

Background:  Although advancements in the management of thoracic aortic disease have led to a reduction in acute mortality, individuals requiring postoperative reintervention experience substantially worse long-term clinical outcomes and increased mortality. We aimed to identify the risk factors for postoperative reintervention in this high-risk population.

Patients and methods:  This prospective observational cohort study included patients who survived endovascular or open surgical treatment for thoracic aortic disease between January 2009 and June 2020. We excluded those with inflammatory or traumatic thoracic aortic diseases. The risk factors were identified using multivariate logistic regression and Cox proportional hazards regression models.

Results:  The study included 95 genetically tested patients aged 54.13 ± 12.13 years, comprising 67 men (70.53%) and 28 women (29.47%). Primary open surgery was performed in 74.7% and endovascular repair in 25.3% of the patients. Of these, 35.8% required one or more reinterventions at the time of follow-up (3 ± 2.5 years, mean ± standard deviation). The reintervention rate was higher in the endovascular repair group than in the open repair group. Among the potential risk factors, only residual aortic dissection emerged as an independent predictor of reintervention (odds ratio: 3.29, 95% confidence interval: 1.25-8.64).

Conclusion:  Reintervention after primary thoracic aortic repair remains a significant clinical issue, even in high-volume tertiary centers. Close follow-up and personalized care at aortic centers are imperative. In our cohort of patients with thoracic aortic disease undergoing open or endovascular surgery, postoperative residual dissection was independently associated with the necessity of reintervention, emphasizing the importance of intensified clinical monitoring in these patients.

背景:尽管胸主动脉疾病治疗的进步降低了急性期死亡率,但需要术后再介入治疗的患者的长期临床预后却大大恶化,死亡率也有所上升。我们旨在确定这一高风险人群术后再介入的风险因素:这项前瞻性观察队列研究纳入了 2009 年 1 月至 2020 年 6 月期间因胸主动脉疾病接受血管内或开放手术治疗后存活的患者。我们排除了患有炎症性或创伤性胸主动脉疾病的患者。采用多变量逻辑回归和 Cox 比例危险度回归模型确定了风险因素:该研究纳入了 95 名经过基因检测的患者,年龄为(54.13 ± 12.13)岁,其中男性 67 人(70.53%),女性 28 人(29.47%)。74.7%的患者接受了初级开放手术,25.3%的患者接受了血管内修复手术。其中,35.8%的患者在随访期间(3 ± 2.5 年,平均值 ± 标准差)需要进行一次或多次再干预。血管内修复组的再介入率高于开放式修复组。在潜在的风险因素中,只有残余主动脉夹层是再介入的独立预测因素(几率比:3.29,95% 置信区间:1.25-8.64):结论:即使是在大容量的三级医疗中心,初次胸主动脉修补术后的再介入仍是一个重要的临床问题。主动脉中心的密切随访和个性化护理势在必行。在我们接受开放手术或血管内手术的胸主动脉疾病患者队列中,术后残余夹层与再次介入的必要性独立相关,强调了对这些患者加强临床监测的重要性。
{"title":"Unpredictable Aortic Behavior in Identifying Risk Factors for Reintervention: A Prospective Cohort Study.","authors":"Mohamed Eraqi, Tamer Ghazy, Tiago Cerqueira, Jennifer Lynne Leip, Timo Siepmann, Adrian Mahlmann","doi":"10.1055/s-0044-1791947","DOIUrl":"10.1055/s-0044-1791947","url":null,"abstract":"<p><strong>Background: </strong> Although advancements in the management of thoracic aortic disease have led to a reduction in acute mortality, individuals requiring postoperative reintervention experience substantially worse long-term clinical outcomes and increased mortality. We aimed to identify the risk factors for postoperative reintervention in this high-risk population.</p><p><strong>Patients and methods: </strong> This prospective observational cohort study included patients who survived endovascular or open surgical treatment for thoracic aortic disease between January 2009 and June 2020. We excluded those with inflammatory or traumatic thoracic aortic diseases. The risk factors were identified using multivariate logistic regression and Cox proportional hazards regression models.</p><p><strong>Results: </strong> The study included 95 genetically tested patients aged 54.13 ± 12.13 years, comprising 67 men (70.53%) and 28 women (29.47%). Primary open surgery was performed in 74.7% and endovascular repair in 25.3% of the patients. Of these, 35.8% required one or more reinterventions at the time of follow-up (3 ± 2.5 years, mean ± standard deviation). The reintervention rate was higher in the endovascular repair group than in the open repair group. Among the potential risk factors, only residual aortic dissection emerged as an independent predictor of reintervention (odds ratio: 3.29, 95% confidence interval: 1.25-8.64).</p><p><strong>Conclusion: </strong> Reintervention after primary thoracic aortic repair remains a significant clinical issue, even in high-volume tertiary centers. Close follow-up and personalized care at aortic centers are imperative. In our cohort of patients with thoracic aortic disease undergoing open or endovascular surgery, postoperative residual dissection was independently associated with the necessity of reintervention, emphasizing the importance of intensified clinical monitoring in these patients.</p>","PeriodicalId":23057,"journal":{"name":"Thoracic and Cardiovascular Surgeon","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A NEW PREDISPOSING FACTOR FOR POSTOPERATIVE ATRIAL FIBRILLATION: TUBE INSERTION SITE. 术后心房颤动的新诱发因素:插管部位。
IF 1.3 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-18 DOI: 10.1055/a-2474-2827
Zinar Apaydın, Barış Timur, Batuhan Yazıcı, Kübra Gözaçık, Anıl Akbaş, Timuçin Aksu, Taner İyigün

Background:  The aim of this study is to compare the insertion sites of drainage tubes placed in the left thorax after elective coronary artery bypass grafting surgeries.

Materials and methods:  Patients were divided into two groups based on the site of tube insertion into the left hemithorax: those with a tube inserted from the subxiphoid region and those with a tube inserted from the left intercostal region. Comparative analyses between these two groups and factor analyses contributing to the outcome were performed.

Results:  There were no significant differences observed in terms of age, gender, height, and weight among patients undergoing coronary artery bypass surgery based on the site of drain placement. Twelve patients (5.2%) required re-drainage procedures, with 5 (41.7%) for pneumothorax and 7 (58.3%) for pleural effusion. Atelectasis was absent in 144 patients (62.1%) while present in 88 patients (37.9%). The frequency of atrial fibrillation was significantly higher in the group with intercostal drains. Additionally, pain scale scores were significantly higher in patients with intercostal drains. Path analysis revealed that the visual pain scale value played a full mediating role in the effect of drain site on atrial fibrillation.

Conclusion:  The statistically significant occurrence of pain and higher rates of postoperative atrial fibrillation in patients with intercostal tube placement are noteworthy. We believe that in patients undergoing elective coronary artery bypass surgery, the drain placed in the left hemithorax should be inserted from the subxiphoid region, if there are no contraindications.

背景: 本研究旨在比较择期冠状动脉旁路移植手术后左胸腔引流管的插入部位: 根据引流管插入左胸腔的部位将患者分为两组:从剑突下插入引流管的患者和从左肋间插入引流管的患者。对这两组患者进行了比较分析,并对影响结果的因素进行了分析: 结果:接受冠状动脉搭桥手术的患者在年龄、性别、身高和体重方面均无明显差异。12名患者(5.2%)需要再次引流,其中5名(41.7%)因气胸,7名(58.3%)因胸腔积液。144名患者(62.1%)无胸腔积液,88名患者(37.9%)有胸腔积液。使用肋间引流管的一组患者发生心房颤动的频率明显较高。此外,使用肋间引流管的患者疼痛量表评分明显更高。路径分析显示,视觉疼痛量表值在引流部位对心房颤动的影响中起着完全的中介作用: 值得注意的是,肋间置管患者的疼痛发生率和术后心房颤动发生率均有统计学意义。我们认为,对于接受择期冠状动脉搭桥手术的患者,如果没有禁忌症,应从剑突下区域插入左胸腔引流管。
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引用次数: 0
Echocardiographic and Clinical Outcomes of Concomitant Secondary Chordal Cutting to Surgical Myectomy in Hypertrophic Obstructive Cardiomyopathy: A Systematic Review and Meta-analysis. 在对 HOCM 进行手术切除的同时进行二次脊髓切断术的临床效果。
IF 1.3 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-18 DOI: 10.1055/a-2434-7627
Tijn Julian Pieter Heeringa, Romy R M J J Hegeman, Len van Houwelingen, Marieke Hoogewerf, David Stecher, Johannes C Kelder, Pim van der Harst, Martin J Swaans, Mostafa M Mokhles, Ilonca Vaartjes, Patrick Klein, Niels P van der Kaaij

In patients who underwent surgical myectomy for hypertrophic obstructive cardiomyopathy (HOCM), additional mitral valve repair may offer additional benefits in terms of further reducing left ventricular outflow tract (LVOT) gradients, systolic anterior motion (SAM), and mitral regurgitation (MR). We performed a systematic review of the literature to evaluate the evidence of surgical myectomy with additional secondary chordal cutting in patients with HOCM. A systematic literature search in MEDLINE and EMBASE was performed until April 2024. The primary outcome studied was postoperative echocardiographic LVOT gradient. A random effects meta-analysis of means was performed for the primary outcome. The secondary outcomes studied were postoperative residual MR grade, 30-day new permanent pacemaker implantation, and in-hospital mortality. From 1,911 unique publications, a total of 6 articles fulfilled the inclusion criteria and comprised 471 patients with a pooled mean preoperative resting LVOT gradient of 84 mm Hg (95% confidence interval [CI]: 76-91). The postoperative pooled mean LVOT gradient was 11 mm Hg (95% CI: 10-12) with a low heterogeneity (I 2 = 44%). The residual LVOT gradient exceeding 30 mm Hg was present in nine (1%) patients. MR grade 3 or 4 at hospital discharge was present in seven (1%) patients. The 30-day new permanent pacemaker implantation rate was 7% and the in-hospital mortality was 0.4%. This systematic review and meta-analysis demonstrate that combining surgical myectomy with secondary chordal cutting can be performed safely and effectively eliminate LVOT obstruction in HOCM patients. Further studies are needed to determine the additive effectiveness of additional secondary chordal cuttings.

目的:对于因肥厚型梗阻性心肌病(HOCM)而接受手术室间隔肌层切除术的患者,额外的二尖瓣修复术可能会在进一步降低左心室流出道(LVOT)梯度、收缩期前移(SAM)和二尖瓣反流(MR)方面带来额外的益处。我们对文献进行了系统性回顾,以评估在对 HOCM 患者进行手术髓腔切除术的同时进行二次弦切的证据:我们在 MEDLINE 和 EMBASE 中进行了系统性文献检索,直至 2024 年 4 月。研究的主要结果是术后超声心动图左心室出口梯度。对主要结果进行了随机效应均值荟萃分析。次要研究结果为术后残留 MR 级、30 天新永久起搏器植入和院内死亡率:在1911篇文章中,共有6篇符合纳入标准,包括471名患者,术前静息左心室梯度的平均值为84 mmHg (95% CI: 76-91)。术后汇总的 LVOT 梯度平均值为 11 mmHg(95% CI:10 - 12),异质性较低(I2 = 44%)。9例(1%)患者的左心室出口残余梯度超过30毫米汞柱。出院时出现 MR 3 级或 4 级的患者有 7 例(1%)。30天新永久起搏器植入率为7%,院内死亡率为0.4%:本系统综述和荟萃分析表明,在 HOCM 患者中,结合手术室间隔 myectomy 切除术和二次弦切可以安全有效地消除 LVOT 阻塞。还需要进一步研究,以确定额外的二次弦切手术的附加效果。
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引用次数: 0
Predictors for length of stay after surgical aortic valve replacement. 手术主动脉瓣置换术后住院时间的预测因素。
IF 1.3 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-13 DOI: 10.1055/a-2466-7245
Nico Arndt, Till Demal, Oliver D Bhadra, Sebastian Ludwig, David Grundmann, Lisa Voigtlaender-Buschmann, Lara Waldschmidt, Laura Hannen, Stefan Blankenberg, Paulus Kirchhof, Lenard Conradi, Hermann Reichenspurner, Niklas Schofer, Andreas Schaefer

Aortic valve replacement improves and prolongs lives of patients with aortic valve disease, but requires significant healthcare resources, which are mainly determined by the length of associated hospital stays. Therefore, this study aims to identify risk factors for extended length of stay after surgical aortic valve replacement. Between 2018 and 2023, 458 consecutive patients underwent isolated surgical aortic valve replacement at our center and were included in our analysis. To identify independent predictors for hospital and intensive care unit stay, multivariable linear regression analysis using backward elimination process was performed. Upon multivariable linear regression, endocarditis [regression coefficient (β) 2.98; 95% confidence interval (CI) 1.51, 4.45; p<0.001)] and prior aortic valve surgery (β 1.72; 95% CI 0.18, 3.26; p=0.029) were associated with prolonged hospital stay. Prior aortic valve surgery was associated with prolonged intensive care unit stay (β 0.99; 95% CI 0.39, 1.59; p=0.001) as well as chronic obstructive pulmonary disease (β 1.61; 95% CI 0.66, 2.55; p=0.001), smaller prosthetic valve sizes (β -0.18; 95% CI -0.30, -0.06; p=0.003), preoperative atrial fibrillation (β 1.06; 95% CI 0.32, 1.79; p=0.005), and reduced left ventricular ejection fraction (β -0.03; 95% CI -0.05, -0.01; p=0.006). Pending further validation, structured programs aiming to accelerate intensive care unit and hospital discharge after surgical aortic valve replacement should focus on patients with prior cardiac surgery, atrial fibrillation, and chronic obstructive pulmonary disease. Surgeons should aim to implant large-diameter valves. Furthermore, the identified predictors should be used to discuss surgical versus transcatheter procedures in the interdisciplinary heart team.

主动脉瓣置换术可改善和延长主动脉瓣疾病患者的生命,但需要大量的医疗资源,而这些资源主要取决于相关住院时间的长短。因此,本研究旨在确定手术主动脉瓣置换术后延长住院时间的风险因素。2018年至2023年期间,458名连续患者在本中心接受了孤立手术主动脉瓣置换术,并纳入了我们的分析。为了确定住院时间和重症监护室住院时间的独立预测因素,我们采用后向排除法进行了多变量线性回归分析。经多变量线性回归,心内膜炎[回归系数 (β) 2.98; 95% 置信区间 (CI) 1.51, 4.45; p
{"title":"Predictors for length of stay after surgical aortic valve replacement.","authors":"Nico Arndt, Till Demal, Oliver D Bhadra, Sebastian Ludwig, David Grundmann, Lisa Voigtlaender-Buschmann, Lara Waldschmidt, Laura Hannen, Stefan Blankenberg, Paulus Kirchhof, Lenard Conradi, Hermann Reichenspurner, Niklas Schofer, Andreas Schaefer","doi":"10.1055/a-2466-7245","DOIUrl":"https://doi.org/10.1055/a-2466-7245","url":null,"abstract":"<p><p>Aortic valve replacement improves and prolongs lives of patients with aortic valve disease, but requires significant healthcare resources, which are mainly determined by the length of associated hospital stays. Therefore, this study aims to identify risk factors for extended length of stay after surgical aortic valve replacement. Between 2018 and 2023, 458 consecutive patients underwent isolated surgical aortic valve replacement at our center and were included in our analysis. To identify independent predictors for hospital and intensive care unit stay, multivariable linear regression analysis using backward elimination process was performed. Upon multivariable linear regression, endocarditis [regression coefficient (β) 2.98; 95% confidence interval (CI) 1.51, 4.45; p<0.001)] and prior aortic valve surgery (β 1.72; 95% CI 0.18, 3.26; p=0.029) were associated with prolonged hospital stay. Prior aortic valve surgery was associated with prolonged intensive care unit stay (β 0.99; 95% CI 0.39, 1.59; p=0.001) as well as chronic obstructive pulmonary disease (β 1.61; 95% CI 0.66, 2.55; p=0.001), smaller prosthetic valve sizes (β -0.18; 95% CI -0.30, -0.06; p=0.003), preoperative atrial fibrillation (β 1.06; 95% CI 0.32, 1.79; p=0.005), and reduced left ventricular ejection fraction (β -0.03; 95% CI -0.05, -0.01; p=0.006). Pending further validation, structured programs aiming to accelerate intensive care unit and hospital discharge after surgical aortic valve replacement should focus on patients with prior cardiac surgery, atrial fibrillation, and chronic obstructive pulmonary disease. Surgeons should aim to implant large-diameter valves. Furthermore, the identified predictors should be used to discuss surgical versus transcatheter procedures in the interdisciplinary heart team.</p>","PeriodicalId":23057,"journal":{"name":"Thoracic and Cardiovascular Surgeon","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of the Expected Difficult Airway with Planned One-Lung Ventilation: A Retrospective Analysis of 44 Cases. 使用计划性单肺通气处理预期困难气道:对 44 例病例的回顾性分析。
IF 1.3 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-12 DOI: 10.1055/s-0044-1791982
Andrea Irouschek, Joachim Schmidt, Andreas Ackermann, Andreas Moritz, Denis I Trufa, Horia Sirbu, Tobias Golditz

Background:  Difficult airway management is essential in anesthesia practice. Particular challenges are posed to patients who require intraoperative one-lung ventilation. Specific guidelines for these scenarios have been lacking. The recent update of German guidelines incorporates recommendations for securing the airway in anticipated difficult airway scenarios in patients requiring one-lung ventilation. However, scientific data on this specific topic is rare.

Methods:  A retrospective analysis was conducted on adult patients undergoing thoracic surgery with one-lung ventilation from 2016 to 2021. During these years, the standard of practice has been in line with the now published guidelines. Patients with anticipated difficult airways were identified, and airway management strategies were analyzed.

Results:  Among 3,197 anesthetic procedures, 44 cases involved anticipated difficult airways, primarily due to prior head and neck tumor treatment. Nasal bronchoscopic awake intubation followed by oral reintubation under videolaryngoscopic inspection and the use of bronchial blockers was the standard procedure. No severe complications were recorded, and one-lung ventilation was maintained successfully in all cases.

Discussion:  The study highlights the challenges of managing difficult airways during thoracic surgery. Recommendations align with recent guidelines, emphasizing the importance of tailored approaches. The use of single-lumen tubes with bronchial blockers appears favorable over double-lumen tubes, offering comparable ventilation quality with reduced risks.

Conclusion:  Despite limitations, the study underscores the safety and efficacy of tailored airway management strategies during one-lung ventilation in patients with anticipated difficult airways. The presented approach offers patient safety and practicability. Further multicenter studies are warranted to validate these findings and refine clinical approaches.

背景:困难气道管理在麻醉实践中至关重要。需要术中单肺通气的患者面临的挑战尤为严峻。目前还缺乏针对这些情况的具体指南。最近更新的德国指南中包含了在需要单肺通气的患者出现预期困难气道情况时如何确保气道安全的建议。然而,有关这一特定主题的科学数据并不多见:方法:我们对 2016 年至 2021 年期间接受单肺通气胸外科手术的成人患者进行了回顾性分析。在这些年中,实践标准一直与现已发布的指南保持一致。对预计气道困难的患者进行了识别,并对气道管理策略进行了分析:结果:在3197例麻醉手术中,44例涉及预期困难气道,主要是由于之前的头颈部肿瘤治疗。标准流程是先进行鼻腔支气管镜清醒插管,然后在视频喉镜检查下进行口腔再插管,并使用支气管阻滞剂。所有病例均未出现严重并发症,并成功维持了单肺通气:讨论:该研究强调了胸外科手术中处理困难气道所面临的挑战。建议与最近的指南一致,强调了量身定制方法的重要性。与双腔管道相比,使用带有支气管阻断器的单腔管道似乎更有优势,可在降低风险的同时提供相当的通气质量:尽管存在局限性,但该研究强调了在单肺通气过程中,对预计气道困难的患者采用量身定制的气道管理策略的安全性和有效性。该方法既能保证患者安全,又切实可行。有必要进一步开展多中心研究,以验证这些发现并完善临床方法。
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引用次数: 0
Conduction disorders after rapid deployment AVR compared to conventional AVR. 与传统 AVR 相比,快速部署 AVR 后会出现传导障碍。
IF 1.3 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-08 DOI: 10.1055/a-2464-2727
Markus Schlömicher, Katrin Prümmer, Peter Haldenwang, Vadim Moustafine, Dinah Berres, Matthias Bechtel, Justus T Strauch

Objectives We evaluated and compared incidence and evolution of atrioventricular and intraventricular conduction disorders following rapid deployment AVR and conventional AVR. Methods 147 patients who underwent isolated rapid deployment AVR between 2017 and 2021 as well as 128 patients after conventional biological AVR in the same period were included in this study. ECGs recorded at baseline, discharge and 12 months were retrospectively analyzed. Results Patients in both groups had comparable a STS score (2.9 ± 1.6 vs 3.1 ± 2.2 p=0.32) and comparable baseline characteristics. At discharge the mean QRS width in the RDAVR group was significantly increased with 117.4  28.6 ms and a mean  QRS width of 21.7  26.3 ms (p<0.001) compared to baseline. No significant changes of QRS width were found in the AVR group with a mean value of 101.2  24.1 ms and a mean  QRS width of 3.9  23.9 ms at discharge (p=0.193). Left bundle branch block was increased in the RDAVR group after 12 months (19.3% vs 5.1% p<0.001) Permanent pacemaker implantation rates were significantly higher in the RDAVR group after 12months. (HR: 4.68; 95% CI: 2.23 - 7.43 p<0.001) Mortality did not differ in both groups after 12 months (HR: 1.09; 95% CI: 0.46 - 1.83; p = 0.835) Conclusions Patients after RDAVR showed significant higher rates of left bundle branch block with significantly increased QRS width and permanent pacemaker implantation after 12 months. However, higher mortality was not observed in the RDAVR group.

目的 我们评估并比较了快速部署 AVR 和传统 AVR 后房室和室内传导障碍的发生率和演变情况。方法 本研究纳入了 2017 年至 2021 年期间接受孤立快速部署房室重建术的 147 例患者,以及同期接受传统生物房室重建术的 128 例患者。对基线、出院和 12 个月时记录的心电图进行回顾性分析。结果 两组患者的 STS 评分相当(2.9 ± 1.6 vs 3.1 ± 2.2 p=0.32),基线特征相当。出院时,RDAVR 组的平均 QRS 宽度显著增加,为 117.4  28.6 ms,而  组的平均 QRS 宽度为 21.7  26.3 ms(p
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引用次数: 0
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