{"title":"儿童呼吸道合胞病毒 (RSV) 预防疗法：我们现在处于什么阶段？","authors":"Marie-Hélène Bourassa, Larry C. Lands","doi":"10.1016/j.prrv.2023.08.005","DOIUrl":null,"url":null,"abstract":"<div><p><span>Respiratory Syncytial Virus (RSV) is a leading cause of hospitalization in </span>young children<span><span> and represents a substantial health-care burden around the world. Advances in research have helped identify the prefusion F protein as the key target component in RSV immunization. In this article, we review the previous, current, and ongoing research efforts for immunization against RSV in children. We present the different types of immunization which include monoclonal antibodies, maternal immunization and vaccines while addressing the challenges of preventing </span>RSV infections<span> in the pediatric population.</span></span></p></div>","PeriodicalId":19658,"journal":{"name":"Paediatric Respiratory Reviews","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Preventative therapies for respiratory Syncytial virus (RSV) in children: Where are we now?\",\"authors\":\"Marie-Hélène Bourassa, Larry C. Lands\",\"doi\":\"10.1016/j.prrv.2023.08.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Respiratory Syncytial Virus (RSV) is a leading cause of hospitalization in </span>young children<span><span> and represents a substantial health-care burden around the world. Advances in research have helped identify the prefusion F protein as the key target component in RSV immunization. In this article, we review the previous, current, and ongoing research efforts for immunization against RSV in children. We present the different types of immunization which include monoclonal antibodies, maternal immunization and vaccines while addressing the challenges of preventing </span>RSV infections<span> in the pediatric population.</span></span></p></div>\",\"PeriodicalId\":19658,\"journal\":{\"name\":\"Paediatric Respiratory Reviews\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Paediatric Respiratory Reviews\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1526054223000490\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Paediatric Respiratory Reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1526054223000490","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
摘要
呼吸道合胞病毒（RSV）是导致幼儿住院治疗的主要原因之一，给全世界的医疗保健带来沉重负担。研究进展有助于确定前融合 F 蛋白是 RSV 免疫接种的关键目标成分。在本文中，我们回顾了以前、现在和正在进行的儿童 RSV 免疫接种研究工作。我们介绍了不同类型的免疫接种，包括单克隆抗体、母体免疫接种和疫苗，同时探讨了在儿科人群中预防 RSV 感染所面临的挑战。
Preventative therapies for respiratory Syncytial virus (RSV) in children: Where are we now?
Respiratory Syncytial Virus (RSV) is a leading cause of hospitalization in young children and represents a substantial health-care burden around the world. Advances in research have helped identify the prefusion F protein as the key target component in RSV immunization. In this article, we review the previous, current, and ongoing research efforts for immunization against RSV in children. We present the different types of immunization which include monoclonal antibodies, maternal immunization and vaccines while addressing the challenges of preventing RSV infections in the pediatric population.
期刊介绍：
Paediatric Respiratory Reviews offers authors the opportunity to submit their own editorials, educational reviews and short communications on topics relevant to paediatric respiratory medicine. These peer reviewed contributions will complement the commissioned reviews which will continue to form an integral part of the journal.
Subjects covered include:
• Epidemiology
• Immunology and cell biology
• Physiology
• Occupational disorders
• The role of allergens and pollutants
A particular emphasis is given to the recommendation of "best practice" for primary care physicians and paediatricians.
Paediatric Respiratory Reviews is aimed at general paediatricians but it should also be read by specialist paediatric physicians and nurses, respiratory physicians and general practitioners.
It is a journal for those who are busy and do not have time to read systematically through literature, but who need to stay up to date in the field of paediatric respiratory and sleep medicine.
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