针对心脏代谢表型病理生理学的精确营养。

IF 6.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Reviews in Endocrine & Metabolic Disorders Pub Date : 2023-10-01 Epub Date: 2023-07-05 DOI:10.1007/s11154-023-09821-5
Christopher E Shannon, Méabh B Ní Chathail, Sinéad M Mullin, Andrew Meehan, Fiona C McGillicuddy, Helen M Roche
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引用次数: 2

摘要

肥胖是一种异质性疾病,伴随着广泛的心脏代谢风险。传统的饮食体重管理模式没有解决个体之间的生物异质性问题,并且灾难性地未能应对肥胖相关疾病的全球流行。营养策略应该超越基本的体重管理,转而针对患者的特定病理生理学。在这篇叙述性综述中,我们概述了组织水平的病理生理过程,这些过程驱动患者异质性形成肥胖患者不同的心脏代谢表型。具体而言,我们讨论了不同的生理学和餐后表型如何揭示脂肪、肝脏或骨骼肌内的关键代谢缺陷,以及肠道微生物组和先天免疫系统的综合参与。最后,我们强调了针对这些途径的潜在精确营养方法,并讨论了最近关于这种针对不同肥胖表型的量身定制的饮食干预措施的有效性的转化证据,以优化心脏代谢益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Precision nutrition for targeting pathophysiology of cardiometabolic phenotypes.

Obesity is a heterogenous disease accompanied by a broad spectrum of cardiometabolic risk profiles. Traditional paradigms for dietary weight management do not address biological heterogeneity between individuals and have catastrophically failed to combat the global pandemic of obesity-related diseases. Nutritional strategies that extend beyond basic weight management to instead target patient-specific pathophysiology are warranted. In this narrative review, we provide an overview of the tissue-level pathophysiological processes that drive patient heterogeneity to shape distinct cardiometabolic phenotypes in obesity. Specifically, we discuss how divergent physiology and postprandial phenotypes can reveal key metabolic defects within adipose, liver, or skeletal muscle, as well as the integrative involvement of the gut microbiome and the innate immune system. Finally, we highlight potential precision nutritional approaches to target these pathways and discuss recent translational evidence concerning the efficacy of such tailored dietary interventions for different obesity phenotypes, to optimise cardiometabolic benefits.

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来源期刊
Reviews in Endocrine & Metabolic Disorders
Reviews in Endocrine & Metabolic Disorders 医学-内分泌学与代谢
CiteScore
14.70
自引率
1.20%
发文量
75
审稿时长
>12 weeks
期刊介绍: Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.
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