{"title":"为艾滋病毒感染者补充硒和锌。","authors":"Samira Pourmoradian, Leila Rezazadeh, Helda Tutunchi, Alireza Ostadrahimi","doi":"10.1024/0300-9831/a000778","DOIUrl":null,"url":null,"abstract":"<p><p><b></b> <i>Background:</i> The Human Immunodeficiency Virus (HIV) epidemic is still a public health concern. Micronutrient deficiencies can fasten the progression of this syndrome. Selenium and zinc are essential trace elements, which exert antioxidant and anti-inflammatory activities in HIV infection. The present overview aimed to evaluate the current knowledge from systematic reviews (SRs) of the effects of selenium and zinc supplementation in HIV patients to show the most updated and comprehensive summary of previous SRs. <i>Methods:</i> The current study was performed according to the guidelines of the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) statements. To assess the quality of articles we used the Measurement Tool to Checklist Assess Systematic Reviews (AMSTAR). PubMed/Medline, Web of Science, Scopus, and EMBASE databases and Google Scholar web search engine were searched up until March 2022, using relevant keywords. <i>Results:</i> Among 3731 articles assessed, five and four studies met the inclusion criteria for selenium and zinc supplementation, respectively. Four studies found that selenium supplementation can be effective in delaying CD4 decline in HIV-infected patients. In four SRs, the dosage of selenium supplementation was 200 μg/day. Three studies, however, reported no significant effect of zinc supplementation on CD4 cell counts, and HIV viral load. The dosage of zinc supplementation ranged from 12 to 100 mg/day. The intervention duration ranged from 2 weeks to 18 months. <i>Conclusion:</i> In the present study, we identified some clinical evidence of a potential beneficial effect of selenium supplementation in HIV-infected patients.</p>","PeriodicalId":13884,"journal":{"name":"International Journal for Vitamin and Nutrition Research","volume":" ","pages":"153-159"},"PeriodicalIF":2.0000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Selenium and zinc supplementation in HIV-infected patients.\",\"authors\":\"Samira Pourmoradian, Leila Rezazadeh, Helda Tutunchi, Alireza Ostadrahimi\",\"doi\":\"10.1024/0300-9831/a000778\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b></b> <i>Background:</i> The Human Immunodeficiency Virus (HIV) epidemic is still a public health concern. Micronutrient deficiencies can fasten the progression of this syndrome. 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引用次数: 0
摘要
背景:人类免疫缺陷病毒(HIV)的流行仍然是一个公共卫生问题。微量营养素缺乏会加速这种综合征的发展。硒和锌是人体必需的微量元素,在 HIV 感染中具有抗氧化和抗炎作用。本综述旨在评估目前从系统综述(SR)中获得的关于硒和锌补充剂对艾滋病患者影响的知识,从而对以往的系统综述进行最新、最全面的总结。研究方法本研究根据 PRISMA(系统综述和 Meta 分析首选报告项目)声明的指导原则进行。为了评估文章的质量,我们使用了系统性综述检查表评估工具(AMSTAR)。截至 2022 年 3 月,我们使用相关关键词搜索了 PubMed/Medline、Web of Science、Scopus 和 EMBASE 数据库以及 Google Scholar 网络搜索引擎。结果:在评估的 3731 篇文章中,分别有 5 项和 4 项研究符合硒和锌补充剂的纳入标准。四项研究发现,补硒可有效延缓艾滋病病毒感染者的 CD4 下降。在四项研究中,补硒剂量为 200 微克/天。但有三项研究报告称,补锌对 CD4 细胞计数和 HIV 病毒载量没有明显影响。补锌剂量从 12 毫克/天到 100 毫克/天不等。干预时间从 2 周到 18 个月不等。结论在本研究中,我们发现了一些临床证据,证明补硒对艾滋病病毒感染者有潜在的益处。
Selenium and zinc supplementation in HIV-infected patients.
Background: The Human Immunodeficiency Virus (HIV) epidemic is still a public health concern. Micronutrient deficiencies can fasten the progression of this syndrome. Selenium and zinc are essential trace elements, which exert antioxidant and anti-inflammatory activities in HIV infection. The present overview aimed to evaluate the current knowledge from systematic reviews (SRs) of the effects of selenium and zinc supplementation in HIV patients to show the most updated and comprehensive summary of previous SRs. Methods: The current study was performed according to the guidelines of the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) statements. To assess the quality of articles we used the Measurement Tool to Checklist Assess Systematic Reviews (AMSTAR). PubMed/Medline, Web of Science, Scopus, and EMBASE databases and Google Scholar web search engine were searched up until March 2022, using relevant keywords. Results: Among 3731 articles assessed, five and four studies met the inclusion criteria for selenium and zinc supplementation, respectively. Four studies found that selenium supplementation can be effective in delaying CD4 decline in HIV-infected patients. In four SRs, the dosage of selenium supplementation was 200 μg/day. Three studies, however, reported no significant effect of zinc supplementation on CD4 cell counts, and HIV viral load. The dosage of zinc supplementation ranged from 12 to 100 mg/day. The intervention duration ranged from 2 weeks to 18 months. Conclusion: In the present study, we identified some clinical evidence of a potential beneficial effect of selenium supplementation in HIV-infected patients.
期刊介绍:
Since 1930 this journal has provided an important international forum for scientific advances in the study of nutrition and vitamins. Widely read by academicians as well as scientists working in major governmental and corporate laboratories throughout the world, this publication presents work dealing with basic as well as applied topics in the field of micronutrients, macronutrients, and non-nutrients such as secondary plant compounds.
The editorial and advisory boards include many of the leading persons currently working in this area.
The journal is of particular interest to:
- Nutritionists
- Vitaminologists
- Biochemists
- Physicians
- Engineers of human and animal nutrition
- Food scientists