Ca2+激活的K+通道调节在动脉粥样硬化和有氧运动训练中的特异性。

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology Current topics in membranes Pub Date : 2022-01-01 DOI:10.1016/bs.ctm.2022.09.005
Eric A Mokelke, Mouhamad Alloosh, Michael Sturek
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引用次数: 0

摘要

血管平滑肌细胞表达多种类型的K+通道。钾通道在调节血管平滑肌收缩和血管平滑肌细胞增殖或表型调节中起着重要作用。有充分的证据表明,Ca2+使这两种看似不同的功能在健康和疾病过程中紧密耦合。由于钾通道在血管收缩、血管舒张、膜电位和平滑肌细胞增殖中具有中心地位,这些通道继续具有作为心血管疾病新治疗靶点的潜力。虽然在生理和病理生理条件下,关于K+通道、血管调节、平滑肌细胞增殖和表型调节之间的完整相互作用仍然存在疑问,但对每一类K+通道对脉管系统收缩和增殖状态的贡献已经有了广泛的了解。本文将利用猪血管平滑肌细胞模型,讨论目前对血管平滑肌细胞中K+通道在健康和疾病中的作用的理解,并特别关注作者关于耐力运动对K+通道功能影响的新科学发现。
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Specificity of Ca2+-activated K+ channel modulation in atherosclerosis and aerobic exercise training.

Vascular smooth muscle cells express several isoforms of a number of classes of K+ channels. Potassium channels play critical roles in the regulation of vascular smooth muscle contraction as well as vascular smooth muscle cell proliferation or phenotypic modulation. There is ample evidence that it is Ca2+ that enables these two seemingly disparate functions to be tightly coupled both in healthy and disease processes. Because of the central position that potassium channels have in vasocontraction, vasorelaxation, membrane potential, and smooth muscle cell proliferation, these channels continue to possess the potential to serve as novel therapeutic targets in cardiovascular disease. While there are questions that remain regarding the complete interactions between K+ channels, vascular regulation, smooth muscle cell proliferation, and phenotypic modulation in physiological and pathophysiological conditions, a broad understanding of the contributions of each class of K+ channel to contractile and proliferative states of the vasculature has been reached. This brief review will discuss the current understanding of the role of K+ channels in vascular smooth muscle cells in health and disease using the porcine vascular smooth muscle cell model with particular attention to new scientific discoveries contributed by the authors regarding the effect of endurance exercise on the function of the K+ channels.

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来源期刊
Current topics in membranes
Current topics in membranes 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
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