三维生物打印组织类似物:当前发展和转化意义。

IF 6.7 1区 工程技术 Q1 CELL & TISSUE ENGINEERING Journal of Tissue Engineering Pub Date : 2023-07-13 eCollection Date: 2023-01-01 DOI:10.1177/20417314231187113
Suihong Liu, Lijia Cheng, Yakui Liu, Haiguang Zhang, Yongteng Song, Jeong-Hui Park, Khandmaa Dashnyam, Jung-Hwan Lee, Fouad Al-Hakim Khalak, Oliver Riester, Zheng Shi, Serge Ostrovidov, Hirokazu Kaji, Hans-Peter Deigner, José Luis Pedraz, Jonathan C Knowles, Qingxi Hu, Hae-Won Kim, Murugan Ramalingam
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引用次数: 0

摘要

三维(3D)生物打印是快速成型制造领域一项前景广阔且发展迅速的技术。它能制造出具有复杂结构的活细胞构建体,适用于各种生物医学应用,如组织工程、疾病建模、药物筛选和精准再生医学。生物打印的最终目标是制造出稳定的、符合解剖学形状的人体级功能器官或组织替代物,并可植入人体。尽管在过去十年中出现了各种生物打印技术来开发定制的组织工程替代物,但在制造具有复杂形状和尺寸的体积组织构建物以及将打印产品转化为临床实践方面仍存在一些挑战。因此,制定成功的战略将研究成果转化为临床实践,以解决当前的器官和组织危机并改善患者的生活质量至关重要。这篇综述文章讨论了现有生物打印工艺在制备临床相关组织替代品方面所面临的挑战。文章进一步回顾了克服限制体积生物构建体制造的挑战的各种策略和技术可行性及其转化意义。此外,文章还重点介绍了解剖学形状组织替代物三维生物打印方面令人兴奋的技术进展,并提出了未来的研究和发展方向。这篇综述旨在让读者深入了解最先进的三维生物打印技术,将其作为工程化功能组织和器官的有力工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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3D Bioprinting tissue analogs: Current development and translational implications.

Three-dimensional (3D) bioprinting is a promising and rapidly evolving technology in the field of additive manufacturing. It enables the fabrication of living cellular constructs with complex architectures that are suitable for various biomedical applications, such as tissue engineering, disease modeling, drug screening, and precision regenerative medicine. The ultimate goal of bioprinting is to produce stable, anatomically-shaped, human-scale functional organs or tissue substitutes that can be implanted. Although various bioprinting techniques have emerged to develop customized tissue-engineering substitutes over the past decade, several challenges remain in fabricating volumetric tissue constructs with complex shapes and sizes and translating the printed products into clinical practice. Thus, it is crucial to develop a successful strategy for translating research outputs into clinical practice to address the current organ and tissue crises and improve patients' quality of life. This review article discusses the challenges of the existing bioprinting processes in preparing clinically relevant tissue substitutes. It further reviews various strategies and technical feasibility to overcome the challenges that limit the fabrication of volumetric biological constructs and their translational implications. Additionally, the article highlights exciting technological advances in the 3D bioprinting of anatomically shaped tissue substitutes and suggests future research and development directions. This review aims to provide readers with insight into the state-of-the-art 3D bioprinting techniques as powerful tools in engineering functional tissues and organs.

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来源期刊
Journal of Tissue Engineering
Journal of Tissue Engineering Engineering-Biomedical Engineering
CiteScore
11.60
自引率
4.90%
发文量
52
审稿时长
12 weeks
期刊介绍: The Journal of Tissue Engineering (JTE) is a peer-reviewed, open-access journal dedicated to scientific research in the field of tissue engineering and its clinical applications. Our journal encompasses a wide range of interests, from the fundamental aspects of stem cells and progenitor cells, including their expansion to viable numbers, to an in-depth understanding of their differentiation processes. Join us in exploring the latest advancements in tissue engineering and its clinical translation.
期刊最新文献
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