唾液采样在治疗药物监测和基于生理的药代动力学建模:综述。

IF 1.7 Q3 PHARMACOLOGY & PHARMACY Drug Research Pub Date : 2023-02-01 DOI:10.1055/a-1956-9313

May Almukainzi

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引用次数: 5

摘要

基于唾液样本的治疗药物监测调查可以作为血液采样的替代方法，具有许多优点。此外，基于生理的药代动力学(PBPK)建模工具的发展可以进一步帮助估计唾液中的药物暴露。本文讨论了唾液样本的使用，并举例说明了PBPK建模系统在估计唾液药物暴露方面的应用和实例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Saliva Sampling in Therapeutic Drug Monitoring and Physiologically Based Pharmacokinetic Modeling: Review.

Therapeutic drug monitoring investigations based on saliva samples can be utilized as an alternative to blood sampling for many advantages. Moreover, the development of physiologically based pharmacokinetic (PBPK) modeling tools can further help to estimate drug exposure from saliva. This review discusses the use of saliva samples and illustrates the applications and examples of PBPK modeling systems for estimating drug exposure from saliva.

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来源期刊

Drug Research PHARMACOLOGY & PHARMACY-

CiteScore

3.50

自引率

0.00%

发文量

期刊介绍： Drug Research (formerly Arzneimittelforschung) is an international peer-reviewed journal with expedited processing times presenting the very latest research results related to novel and established drug molecules and the evaluation of new drug development. A key focus of the publication is translational medicine and the application of biological discoveries in the development of drugs for use in the clinical environment. Articles and experimental data from across the field of drug research address not only the issue of drug discovery, but also the mathematical and statistical methods for evaluating results from industrial investigations and clinical trials. Publishing twelve times a year, Drug Research includes original research articles as well as reviews, commentaries and short communications in the following areas: analytics applied to clinical trials chemistry and biochemistry clinical and experimental pharmacology drug interactions efficacy testing pharmacodynamics pharmacokinetics teratology toxicology.