含芦荟提取物的芬太尼透皮治疗基质改善粘连、皮肤耐受性和生活质量:德国一项使用新型芬太尼贴片的多中心研究结果

IF 1.7 Q3 PHARMACOLOGY & PHARMACY Drug Research Pub Date : 2023-02-01 DOI:10.1055/a-1960-2879
Christoph G Dietrich, Tanja Kottmann, Hans Werner Voß, Roxane Lorenz
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引用次数: 1

摘要

背景:慢性疼痛是一个重要的和昂贵的医疗保健问题,特别是在老年患者。经皮阿片类药物治疗易于应用,并确保有效成分的持续供应。然而,皮肤刺激,粘连不良和全身副作用使透皮疼痛治疗复杂化。方法:在德国54个中心的Relief研究中,共招募患者252例,收集芦荟芬太尼贴片的一般护理情况、特点、作用和副作用等资料。92例患者之前接受过不含芦荟的芬太尼贴片治疗,允许进行比较分析。结果:与不含芦荟的贴片相比,新芬太尼贴片具有更好的粘附性。全身和局部耐受性和疼痛减轻也明显改善。患者还报告了副作用和生活质量中心参数的改善。有关德国护理情况的数据显示,止痛剂和泻药在疼痛患者中的使用率非常低。讨论:芦荟在透皮疼痛治疗中可改善贴片的粘连和局部耐受性。疼痛控制和生活质量也得到改善。本研究中关于疼痛治疗中共同治疗的区域护理数据表明,在全科医生的疼痛治疗中缺乏对现有指南的渗透。
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Aloe Vera-Containing Matrix in Transdermal Fentanyl Therapy Improves Adhesion, Skin Tolerance and Quality of Life: Results of a German Multicenter Study with a New Fentanyl Patch.

Background: Chronic pain represents a significant and costly healthcare problem especially in the older patient. Transdermal opioid therapy is easy to apply and ensures constant supply of active ingredients. However, skin irritation, poor adhesion and systemic side effects complicate transdermal pain therapy.

Methods: In the Relief study, comprising 54 centers, all in Germany, 252 patients were recruited and data about the general care situation as well as the characteristics, effects and side effects of the Aloe vera fentanyl patch were collected. 92 patients had a prior treatment with fentanyl patch without Aloe vera, allowing a comparative analysis.

Results: Compared to patches without Aloe vera, the new fentanyl patch showed better adhesion. Systemic and local tolerance and pain reduction were also significantly better. Patients also reported improvements in side effects and central parameters of quality of life. The data regarding the care situation in Germany showed remarkably low use of coanalgetics and laxatives in pain patients.

Discussion: Aloe vera in transdermal pain treatment improves adhesion and local tolerance of the patch. Pain control and quality of life were also improved. Regional care data concerning cotreatment in pain therapy from this study indicate a lack of penetration of existing guidelines in general practitioners' pain therapy.

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来源期刊
Drug Research
Drug Research PHARMACOLOGY & PHARMACY-
CiteScore
3.50
自引率
0.00%
发文量
67
期刊介绍: Drug Research (formerly Arzneimittelforschung) is an international peer-reviewed journal with expedited processing times presenting the very latest research results related to novel and established drug molecules and the evaluation of new drug development. A key focus of the publication is translational medicine and the application of biological discoveries in the development of drugs for use in the clinical environment. Articles and experimental data from across the field of drug research address not only the issue of drug discovery, but also the mathematical and statistical methods for evaluating results from industrial investigations and clinical trials. Publishing twelve times a year, Drug Research includes original research articles as well as reviews, commentaries and short communications in the following areas: analytics applied to clinical trials chemistry and biochemistry clinical and experimental pharmacology drug interactions efficacy testing pharmacodynamics pharmacokinetics teratology toxicology.
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