螺旋钻治疗中激光-康普顿散射的x射线增强研究。

IF 2.1 4区 医学 Q2 BIOLOGY International Journal of Radiation Biology Pub Date : 2023-01-01 DOI:10.1080/09553002.2020.1811420
Yuya Koshiba, Ryosuke Morita, Koki Yamashita, Masakazu Washio, Kazuyuki Sakaue, Takeshi Higashiguchi, Junji Urakawa
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引用次数: 0

摘要

目的:高亮度的单色硬x射线用于包括俄歇治疗在内的医疗应用。人们可以通过激光-康普顿散射(LCS)产生这种x射线,方法是让来自紧凑激光系统的光子与紧凑电子加速器加速的电子相互作用。本文在简要介绍激光-康普顿x射线源的基础上,提出了一种叫做螃蟹交叉的增强x射线强度的方案。本文对螃蟹交叉效应进行了评价,并报道了用于螃蟹交叉LCS研究的专用激光系统。材料与方法:用蟹状交叉法对其光度增强系数进行了评价。对于电子束,将使用射频偏转器产生倾斜的电子束。激光系统采用啁啾脉冲放大。采用掺镱光纤和Yb:YAG薄板作为激光增益介质。结果:当交叉角为45°时,螃蟹交叉的亮度增强系数为3.8。采用薄盘再生放大器实现10mJ脉冲能量。经过脉冲压缩后的脉冲持续时间约为1.5 ps。结论:利用电子束与激光脉冲的蟹式交叉,证明了LCS x射线的增强作用。预期的增强系数为3.8。我们已经成功地完成了激光器的研制,并将很快进行原理验证实验。
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Study on X-ray enhancement in Laser-Compton scattering for auger therapy.

Purpose: Monochromatic hard X-rays with high brightness are desired for medical applications including Auger therapy. One can generate such X-rays through laser-Compton scattering (LCS) by allowing photons from a compact laser system to interact with electrons accelerated by a compact electron accelerator. In this paper, after a brief description of laser-Compton X-ray sources, a scheme called crab crossing to enhance the X-ray intensity is proposed. The effect of crab crossing is evaluated, and we report our dedicated laser system for the crab crossing LCS research.

Materials and methods: The luminosity enhancement factor by crab crossing is evaluated. For the electron beam, a rf deflector will be used to generate a tilted electron beam. For the laser system, chirped pulsed amplification is adopted. Yb-doped optical fibers and a Yb:YAG thin-disk is used for the laser gain media.

Results: The luminosity enhancement factor by crab crossing is expected to be 3.8 when the crossing angle is 45 degrees. 10mJ pulse energy was achieved by thin-disk regenerative amplifier. The pulse duration after the pulse compressor was about 1.5 ps.

Conclusion: We are going to demonstrate the LCS X-ray enhancement by crab crossing of electron beam and laser pulse. The expected enhancement factor is 3.8. We have successfully finished the laser development and the proof-of-principle experiment will be conducted soon.

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来源期刊
CiteScore
5.00
自引率
11.50%
发文量
142
审稿时长
3 months
期刊介绍: The International Journal of Radiation Biology publishes original papers, reviews, current topic articles, technical notes/reports, and meeting reports on the effects of ionizing, UV and visible radiation, accelerated particles, electromagnetic fields, ultrasound, heat and related modalities. The focus is on the biological effects of such radiations: from radiation chemistry to the spectrum of responses of living organisms and underlying mechanisms, including genetic abnormalities, repair phenomena, cell death, dose modifying agents and tissue responses. Application of basic studies to medical uses of radiation extends the coverage to practical problems such as physical and chemical adjuvants which improve the effectiveness of radiation in cancer therapy. Assessment of the hazards of low doses of radiation is also considered.
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