SARS-CoV-2感染可能是多发性硬化症的新危险因素吗?

IF 2.2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Neuroimmunomodulation Pub Date : 2022-01-01 DOI:10.1159/000521891
Rehab Magdy, Mona Hussein
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引用次数: 2

摘要

新型严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2)的爆发给全球卫生保健界带来了挑战。SARS-CoV-2主要影响呼吸系统;然而,强有力的证据表明,SARS-CoV-2可能是神经侵入性的,导致几种神经系统并发症。以前认为,一些冠状病毒通过各种机制参与多发性硬化症(MS)的病理。冠状病毒诱导的中枢脱髓鞘的机制是复杂的,而且在很大程度上是冗余的。分子模仿被认为是一种可能的机制。血脑屏障的破坏、几种炎症细胞因子的失调和基质金属蛋白酶的上调也被认为是导致中枢性脱髓鞘病理的原因。这就提出了一个问题,即SARS-CoV-2作为多发性硬化症的新危险因素可能发挥的作用。
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Could SARS-CoV-2 Infection Be a Novel Risk Factor for Multiple Sclerosis?

The outbreak of the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has challenged the healthcare community worldwide. The SARS-CoV-2 primarily affects the respiratory system; however, strong evidence suggests that SARS-CoV-2 can be neuroinvasive, resulting in several neurological complications. It was previously assumed that some coronaviruses are involved in multiple sclerosis (MS) pathology via various mechanisms. The mechanisms involved in coronavirus-induced central demyelination are complex and largely redundant. Molecular mimicry was proposed to be one of the possible mechanisms. Disruption of the blood-brain barrier, dysregulation in several inflammatory cytokines, and upregulation of matrix metalloproteinases were also thought to induce central demyelinating pathology. This raises a question about the possible role of SARS-CoV-2 as a novel risk factor for MS.

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来源期刊
Neuroimmunomodulation
Neuroimmunomodulation 医学-免疫学
CiteScore
3.60
自引率
4.20%
发文量
35
审稿时长
>12 weeks
期刊介绍: The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, ''Neuroimmunomodulation'' reports on all aspects of these interactions. Basic investigations consider all neural and humoral networks from molecular genetics through cell regulation to integrative systems of the body. The journal also aims to clarify the basic mechanisms involved in the pathogenesis of the CNS pathology in AIDS patients and in various neurodegenerative diseases. Although primarily devoted to research articles, timely reviews are published on a regular basis.
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