密歇根州底特律市成人血清铅、汞、锰、铜和DNA甲基化年龄

IF 4.8 Q1 GENETICS & HEREDITY Environmental Epigenetics Pub Date : 2022-01-01 DOI:10.1093/eep/dvac018
Evans K Lodge, Radhika Dhingra, Chantel L Martin, Rebecca C Fry, Alexandra J White, Cavin K Ward-Caviness, Agaz H Wani, Monica Uddin, Derek E Wildman, Sandro Galea, Allison E Aiello
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引用次数: 0

摘要

虽然铅、汞、锰和铜对个别疾病过程的影响已得到充分了解,但很难估计在一般人群中经常观察到的低浓度长期接触这些金属对健康的影响。此外,关节接触多种金属对健康的影响难以估计。生物衰老是指多种生理和分子变化的综合进展,使个体更容易患病。生物老化的生物标记物可能有助于在人群中疾病发展之前估计金属暴露的人群水平效应。我们使用了底特律社区健康研究中290名参与者的数据来估计血清铅、汞、锰和铜对三种基于DNA甲基化的生物衰老标志物(Horvath Age、PhenoAge和GrimAge)的影响。我们使用混合模型和贝叶斯核机回归,并控制了参与者的性别、种族、民族、吸烟、收入、受教育程度和街区群体贫困。我们观察到铅和GrimAge加速以及汞和PhenoAge加速之间的影响一直是积极的。相反,我们观察到锰和表型年龄加速、汞和Horvath年龄加速之间始终呈负相关。我们还观察到铜与PhenoAge和GrimAge加速之间的曲线关系。增加所观察到的金属混合物的总暴露与增加的表型年龄和GrimAge加速以及减少的Horvath年龄加速有关。这些发现表明,在密歇根州底特律的成年人群中,血清铅或汞从第25至75百分位增加,与两种全因死亡率表观遗传标记增加约0.25年有关。虽然这些发现很少有统计学意义,但它们的一致性和新颖性值得关注。
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Serum lead, mercury, manganese, and copper and DNA methylation age among adults in Detroit, Michigan.

Although the effects of lead, mercury, manganese, and copper on individual disease processes are well understood, estimating the health effects of long-term exposure to these metals at the low concentrations often observed in the general population is difficult. In addition, the health effects of joint exposure to multiple metals are difficult to estimate. Biological aging refers to the integrative progression of multiple physiologic and molecular changes that make individuals more at risk of disease. Biomarkers of biological aging may be useful to estimate the population-level effects of metal exposure prior to the development of disease in the population. We used data from 290 participants in the Detroit Neighborhood Health Study to estimate the effect of serum lead, mercury, manganese, and copper on three DNA methylation-based biomarkers of biological aging (Horvath Age, PhenoAge, and GrimAge). We used mixed models and Bayesian kernel machine regression and controlled for participant sex, race, ethnicity, cigarette use, income, educational attainment, and block group poverty. We observed consistently positive estimates of the effects between lead and GrimAge acceleration and mercury and PhenoAge acceleration. In contrast, we observed consistently negative associations between manganese and PhenoAge acceleration and mercury and Horvath Age acceleration. We also observed curvilinear relationships between copper and both PhenoAge and GrimAge acceleration. Increasing total exposure to the observed mixture of metals was associated with increased PhenoAge and GrimAge acceleration and decreased Horvath Age acceleration. These findings indicate that an increase in serum lead or mercury from the 25th to 75th percentile is associated with a ∼0.25-year increase in two epigenetic markers of all-cause mortality in a population of adults in Detroit, Michigan. While few of the findings were statistically significant, their consistency and novelty warrant interest.

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来源期刊
Environmental Epigenetics
Environmental Epigenetics GENETICS & HEREDITY-
CiteScore
6.50
自引率
5.30%
发文量
0
审稿时长
17 weeks
期刊最新文献
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