苍蝇和蠕虫性二态神经系统模式化的分子机制

IF 11.4 1区 生物学 Q1 CELL BIOLOGY Annual review of cell and developmental biology Pub Date : 2021-10-06 DOI:10.1146/annurev-cellbio-120319-115237
Stephen F Goodwin, Oliver Hobert
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引用次数: 0

摘要

雄性和雌性大脑在解剖学和功能上存在差异。这种差异在包括人类在内的动物界所有物种中都能观察到,但在两个经典的动物模型系统--黑腹果蝇和线虫--中的研究尤为深入。在此,我们总结了在了解蠕虫和蝇类大脑如何在发育过程中获得性双态特征方面的最新进展。我们强调了每种系统的优势,说明了对蠕虫性二态性的精确解剖学划分是如何促成了最近对这些二态性如何在发育过程中特定化的分析,以及对果蝇性二态性神经元的关注是如何促成了对性别特异性行为越来越详细的了解。
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Molecular Mechanisms of Sexually Dimorphic Nervous System Patterning in Flies and Worms.

Male and female brains display anatomical and functional differences. Such differences are observed in species across the animal kingdom, including humans, but have been particularly well-studied in two classic animal model systems, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans. Here we summarize recent advances in understanding how the worm and fly brain acquire sexually dimorphic features during development. We highlight the advantages of each system, illustrating how the precise anatomical delineation of sexual dimorphisms in worms has enabled recent analysis into how these dimorphisms become specified during development, and how focusing on sexually dimorphic neurons in the fly has enabled an increasingly detailed understanding of sex-specific behaviors.

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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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