Jinrong Zhao, Jinpei Wang, Dong Zhao, Lin Wang, Xiaoe Luo
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引用次数: 0
摘要
背景:十几项研究调查了atp结合盒转运蛋白A1 (ABCA1)基因R219K变异对阿尔茨海默病(AD)风险的影响，但结果相互矛盾。目的:我们进行了一项系统回顾和荟萃分析，以全面评估ABCA1 R219K变异与AD风险之间的关系。方法:通过检索PubMed、Web of Science和AlzGene获得纳入meta分析的研究。采用Review Manager 5.4进行meta分析。采用比值比(OR)及其95%置信区间(CI)评价ABCA1 R219K多态性对AD易感性的影响。采用I2统计和Cochran Qtest评估纳入研究之间的异质性。采用漏斗图评估发表偏倚。结果:从PubMed、Web of Science和AlzGene中共检索到14项符合条件的研究，涉及10084名受试者。meta分析结果显示，在隐性模型下，R219K多态性与中国人AD风险降低显著相关(OR = 0.67;95% ci = 0.51- 0.88;P = 0.004)。结论:本荟萃分析提示R219K多态性的KK基因型可能是中国人群AD的保护因素。需要更多样本量更大的研究来进一步证实这种关联。
Association Between ABCA1 R219K Variant and Alzheimer's Disease: An Updated Meta-Analysis and Systematic Review.
Background: Over a dozen studies have investigated the effect of the R219K variant in the ATP-binding cassette transporter A1 (ABCA1) gene on the risk of Alzheimer's disease (AD), but the results are conflicting.
Objective: We performed a systematic review and meta-analysis to comprehensively assess the association between the ABCA1 R219K variant and the risk of AD.
Methods: Studies included in the meta-analysis were obtained by searching PubMed, Web of Science and AlzGene. Review Manager 5.4 was used for meta-analysis. Both the odds ratio (OR) and its 95% confidence interval (CI) were used to evaluate the effect of ABCA1 R219K polymorphism on AD susceptibility. Heterogeneity between the included studies was assessed using I2 statistics and Cochran Qtest. Funnel plots were used to assess publication bias.
Results: A total of 14 eligible studies involving 10084 subjects were retrieved from PubMed, Web of Science and AlzGene. Meta-analysis results showed that R219K polymorphism was significantly associated with a decreased risk of AD in Chinese under a recessive model (OR = 0.67; 95% CI = 0.51- 0.88; P = 0.004).
Conclusion: The present meta-analysis indicated that the KK genotype of R219K polymorphism may act as a protective factor for AD in the Chinese population. Additional studies with larger sample sizes are needed to further confirm this association.
期刊介绍：
Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.
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