Floris W Haijer, Cornelis B Van Vliet, Marjolein G J Brusse-Keizer, Job A M Van der Palen, Marjo J Kerbert-Dreteler, Jeroen J Kolkman
{"title":"-谷氨酰转移酶:对抗胆汁淤积性瘙痒的朋友?肝外胆汁淤积症患者的回顾性观察资料分析。","authors":"Floris W Haijer, Cornelis B Van Vliet, Marjolein G J Brusse-Keizer, Job A M Van der Palen, Marjo J Kerbert-Dreteler, Jeroen J Kolkman","doi":"10.1155/2023/2903171","DOIUrl":null,"url":null,"abstract":"<p><strong>Methods: </strong>We included 235 patients with chronic extrahepatic cholestasis due to pancreatic cancer, cholangiocarcinoma, or papillary carcinoma.</p><p><strong>Results: </strong>GGT was significantly higher in patients without pruritus (median 967, IQR 587-1571) compared to patients with pruritus (median 561 IQR 266-1084 IU/l) (<i>p</i> < 0.01). In contrast, median alkaline phosphatase (AP) was 491 U/L (IQR; 353-684) in patients with pruritus and was not significantly different from 518 U/L (IQR; 353-726) in patients without pruritus (<i>p</i> = 0.524). Direct bilirubin was significantly higher in patients with pruritus compared to patients without pruritus (168 <i>μ</i>mol/L (IQR; 95-256) vs. 120 <i>μ</i>mol/L (IQR; 56.75-185.5)) (<i>p</i> < 0.01). After correcting for the extent of cholestasis <i>via</i> direct bilirubin, the negative association between GGT and pruritus remained significant and became stronger (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Serum GGT activity is inversely associated with the presence of cholestatic itch in patients with chronic extrahepatic cholestasis.</p>","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"2023 ","pages":"2903171"},"PeriodicalIF":1.5000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931488/pdf/","citationCount":"0","resultStr":"{\"title\":\"Gamma-Glutamyl Transferase: A Friend against Cholestatic Itch? A Retrospective Observational Data Analysis in Patients with Extrahepatic Cholestasis.\",\"authors\":\"Floris W Haijer, Cornelis B Van Vliet, Marjolein G J Brusse-Keizer, Job A M Van der Palen, Marjo J Kerbert-Dreteler, Jeroen J Kolkman\",\"doi\":\"10.1155/2023/2903171\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Methods: </strong>We included 235 patients with chronic extrahepatic cholestasis due to pancreatic cancer, cholangiocarcinoma, or papillary carcinoma.</p><p><strong>Results: </strong>GGT was significantly higher in patients without pruritus (median 967, IQR 587-1571) compared to patients with pruritus (median 561 IQR 266-1084 IU/l) (<i>p</i> < 0.01). In contrast, median alkaline phosphatase (AP) was 491 U/L (IQR; 353-684) in patients with pruritus and was not significantly different from 518 U/L (IQR; 353-726) in patients without pruritus (<i>p</i> = 0.524). Direct bilirubin was significantly higher in patients with pruritus compared to patients without pruritus (168 <i>μ</i>mol/L (IQR; 95-256) vs. 120 <i>μ</i>mol/L (IQR; 56.75-185.5)) (<i>p</i> < 0.01). After correcting for the extent of cholestasis <i>via</i> direct bilirubin, the negative association between GGT and pruritus remained significant and became stronger (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Serum GGT activity is inversely associated with the presence of cholestatic itch in patients with chronic extrahepatic cholestasis.</p>\",\"PeriodicalId\":46297,\"journal\":{\"name\":\"International Journal of Hepatology\",\"volume\":\"2023 \",\"pages\":\"2903171\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931488/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Hepatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2023/2903171\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Hepatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2023/2903171","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Gamma-Glutamyl Transferase: A Friend against Cholestatic Itch? A Retrospective Observational Data Analysis in Patients with Extrahepatic Cholestasis.
Methods: We included 235 patients with chronic extrahepatic cholestasis due to pancreatic cancer, cholangiocarcinoma, or papillary carcinoma.
Results: GGT was significantly higher in patients without pruritus (median 967, IQR 587-1571) compared to patients with pruritus (median 561 IQR 266-1084 IU/l) (p < 0.01). In contrast, median alkaline phosphatase (AP) was 491 U/L (IQR; 353-684) in patients with pruritus and was not significantly different from 518 U/L (IQR; 353-726) in patients without pruritus (p = 0.524). Direct bilirubin was significantly higher in patients with pruritus compared to patients without pruritus (168 μmol/L (IQR; 95-256) vs. 120 μmol/L (IQR; 56.75-185.5)) (p < 0.01). After correcting for the extent of cholestasis via direct bilirubin, the negative association between GGT and pruritus remained significant and became stronger (p < 0.001).
Conclusion: Serum GGT activity is inversely associated with the presence of cholestatic itch in patients with chronic extrahepatic cholestasis.
期刊介绍：
International Journal of Hepatology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the medical, surgical, pathological, biochemical, and physiological aspects of hepatology, as well as the management of disorders affecting the liver, gallbladder, biliary tree, and pancreas.
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