预先确定的顺势疗法药物在接受标准治疗的无症状COVID-19患者中的比较效果——一项开放标签、随机、对照的探索性试验

IF 1.2 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Homeopathy Pub Date : 2022-11-01 DOI:10.1055/s-0042-1745754

Roja Varanasi, Sunita Tomar, Sanjay Gupta, Praveen Jaiswal, Ankit Srivastava, Vijendra Parmar, Shradha Chauhan, Arvind Kumar, Shivendra Kumar Mishra, Anil Khurana

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引用次数: 2

摘要

背景:无症状感染者可传播长达14天，被认为是新冠肺炎大流行快速传播的重要因素。本探索性研究旨在确定在接受标准治疗的无症状COVID-19患者中，与安慰剂相比，所选顺势疗法药物的任何额外益处。方法:这项开放标签、随机、安慰剂对照的探索性试验在印度中央邦的一家COVID护理中心(CCC)进行。纳入入院时RT-PCR阳性且无症状的患者(n = 200, 18-65岁，男女)。他们被随机分为四组(每组n = 50): Arsenicum专辑30C (Ars;alb.)，樟树1M (Camph.)，白桦30C (Bry.)。alb.)和安慰剂(Pl.)。所有患者均接受标准治疗。主要结局是在第5、10和15天SARS-CoV-2 RT-PCR阴性的患者人数。结果:共纳入200例无症状COVID-19患者。177例患者在第15天变为RT-PCR阴性;88%， 80%， 98%和88%来自Ars。铝青铜。, Camph。, Bry。铝青铜。和Pl.分别。各组SARS-Cov-2 RT-PCR阴性患者总数的卡方相关性检验显示有边际统计学意义(卡方:8.1,p = 0.04)。将每种预先确定的顺势疗法药物与安慰剂进行双比例z检验，结果显示Bry alb具有边际统计学意义(p = 0.05)。只有。每组RT-PCR阴性的中位时间(Kaplan Meier分析)为10天。结论:有证据表明，与白藜芦醇相比，, Camph。或者我叫布莱。铝青铜。与在第15天成为COVID-19 RT-PCR阴性的患者数量增加有关。可能产生的影响需要在进一步的研究中调查。

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Comparative Effectiveness of Pre-Identified Homeopathic Medicines in Asymptomatic COVID-19 Individuals Receiving Standard Care-An Open-Label, Randomized, Controlled Exploratory Trial.

Background: Asymptomatic COVID-19 subjects can transmit the infection for as many as 14 days and are regarded as a significant factor in the rapid spread of the COVID-19 pandemic. This exploratory study aimed to determine any additional benefits of selected homeopathic medicines compared with placebo in asymptomatic COVID-19 individuals receiving standard care.

Methods: This open-label, randomized, placebo-controlled, exploratory trial was undertaken at a COVID Care Centre (CCC) in Madhya Pradesh, India. Patients (n = 200, 18-65 years, both sexes) having a positive RT-PCR and asymptomatic during admission were enrolled. They were randomly assigned to one of four groups (each n = 50): Arsenicum album 30C (Ars. alb.), Camphora 1M (Camph.), Bryonia alba 30C (Bry. alb.) and placebo (Pl.). All the patients were given standard care. The primary outcome was the number of patients becoming RT-PCR negative for SARS-CoV-2 at days 5, 10 and 15.

Results: In total, 200 asymptomatic COVID-19 patients were enrolled. One hundred and seventy-seven patients became RT-PCR negative by day 15; 88%, 80%, 98% and 88% from Ars. alb., Camph., Bry. alb. and Pl. respectively. A Chi-square test of association for the total patients who became RT-PCR negative for SARS-Cov-2 in each group showed a marginal statistical significance (Chi-square: 8.1, p = 0.04). A two-proportion Z-test comparing each pre-identified homeopathic medicine with placebo showed marginal statistical significance (p = 0.05) for Bry alb. only. Median time in days to RT-PCR negative (Kaplan Meier analysis) was 10 days in each of the groups.

Conclusion: There was some evidence that, compared with Ars alb., Camph. or Pl., Bry. alb. was associated with an increased number of patients who became RT-PCR negative for COVID-19 by day 15. The possible effect exerted needs to be investigated in additional research.

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来源期刊

Homeopathy 医学-全科医学与补充医学

CiteScore

3.40

自引率

70.60%

发文量

审稿时长

20.1 weeks

期刊介绍： Homeopathy is an international peer-reviewed journal aimed at improving the fundamental understanding and clinical practice of homeopathy by publishing relevant high-quality original research articles, reviews, and case reports. It also promotes commentary and debate on matters of topical interest in homeopathy.