半ipn水凝胶的胶原蛋白和阿拉伯胶具有抗菌能力和药物控释在伤口愈合的潜在应用。

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL Progress in Biomaterials Pub Date : 2023-03-01 DOI:10.1007/s40204-022-00210-w
Nadia J Amaya-Chantaca, Martin Caldera-Villalobos, Jesús A Claudio-Rizo, Tirso E Flores-Guía, Juan J Becerra-Rodríguez, Florentino Soriano-Corral, Adán Herrera-Guerrero
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引用次数: 5

摘要

以胶原蛋白和阿拉伯胶等生物聚合物为基础制备水凝胶,为生物医学领域提供了新的选择。通过聚合物半互渗技术,胶原基聚合物基质可以与阿拉伯胶结合,同时控制其物理化学和生物特性。为了创造具有潜在应用于伤口治疗的新型水凝胶,研究人员探索了半渗透过程,改变胶原基质中阿拉伯胶的浓度(重量0-40%)。阿拉伯树胶在胶原基质中形成分子间氢键的能力,使得基于半互穿聚合物网络(半ipn)的水凝胶的发展具有更快的凝胶时间和更高的交联性。在含有30%(按重量计)阿拉伯胶的基质中,存在多孔性的无定形颗粒表面,增强了储存模量和耐热降解性。水凝胶在水解和蛋白水解环境中膨胀程度非常高,具有良好的血液相容性,并能抑制大肠杆菌等病原体的生长,阿拉伯胶除了能控制酮酸的释放外,还能增强水凝胶的功能。这些半ipn基质的化学成分对单核细胞或成纤维细胞无有害作用,促进其增殖,降低人单核细胞α-肿瘤坏死因子(α-TNF)的分泌。
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Semi-IPN hydrogels of collagen and gum arabic with antibacterial capacity and controlled release of drugs for potential application in wound healing.

The preparation of hydrogels based on biopolymers like collagen and gum arabic gives a chance to provide novel options that can be used in biomedical field. Through a polymeric semi-interpenetration technique, collagen-based polymeric matrices can be associated with gum arabic while controlling its physicochemical and biological properties. To create novel hydrogels with their potential use in the treatment of wounds, the semi-interpenetration process, altering the concentration (0-40% by wt) of gum arabic in a collagen matrix is explored. The ability of gum arabic to create intermolecular hydrogen bonds in the collagen matrix enables the development of semi-interpenetrating polymeric networks (semi-IPN)-based hydrogels with a faster gelation time and higher crosslinking. Amorphous granular surfaces with linked porosity are present in matrices with 30% (by wt) of gum arabic, enhancing the storage modulus and thermal degradation resistance. The hydrogels swell to very high extent in hydrolytic and proteolytic environments, good hemocompatibility, and suppression of growth of pathogens like E. coli, and all it is enhanced by gum arabic included them, in addition to enabling the controlled release of ketorolac. The chemical composition of theses semi-IPN matrices have no deleterious effects on monocytes or fibroblasts, promoting their proliferation, and lowering alpha tumor necrosis factor (α-TNF) secretion in human monocytes.

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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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